Protein Alignment dimm and HAND1

DIOPT Version :10

• Sequence 1: NP_523611.1
• Gene: dimm / 35404
• FlyBaseID: FBgn0023091
• Length: 390
• Species: Drosophila melanogaster
• Sequence 2: NP_004812.1
• Gene: HAND1 / 9421
• HGNCID: 4807
• Length: 215
• Species: Homo sapiens
• Alignment Length: 247
• Identity: 65/247 - (26%)
• Similarity: 93/247 - (37%)
• Gaps: 63/247 - (25%)

  Fly     9 LMGSHDFMQLQHQLHHNNNNYNTDGHNGLSSESAEGSSRPVRRATRRTSQLSNNTYDLEMTDSSS 73
            |:||:        .||:::::....|..|......|   |..|..:.....  .::.|...|:
Human     3 LVGSY--------AHHHHHHHPHPAHPMLHEPFLFG---PASRCHQERPYF--QSWLLSPADA-- 52

  Fly    74 QSDDTSGGGGSSNGGGSTTNTGHPSGCSLGGQGPSGRGRVQQASSGACPSTIAPNSTSSNSSNAN 138
             :.|...||.......:.|..| |.  :..||.|   ||::                      |.
Human    53 -APDFPAGGPPPAAAAAATAYG-PD--ARPGQSP---GRLE----------------------AL 88

  Fly   139 GNASRRRKGALNAKERNMRRLESNERERMRMHSLNDAFQSLREVIPHVEMERRLSKIETLTLAKN 203
            |....||||:            ..::||.|..|:|.||..|||.||:|..:.:||||:||.||.:
Human    89 GGRLGRRKGS------------GPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATS 141

  Fly   204 YIINLTHII---LSKRNEEAAALELNSGAVGG---VLLSNLSSESGGPVASG 249
            ||..|..::   ....:.||...||.. |.||   .....|....|.|.|.|
Human   142 YIAYLMDVLAKDAQSGDPEAFKAELKK-ADGGRESKRKRELQQHEGFPPALG 192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dimm	NP_523611.1	bHLH_TS_dimmed_like	157..216	CDD:381555	24/61 (39%)
HAND1	NP_004812.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..109		20/95 (21%)
		bHLH_TS_HAND1	94..153	CDD:381522	28/70 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..198		9/28 (32%)