Protein Alignment dimm and TWIST1

DIOPT Version :10

• Sequence 1: NP_523611.1
• Gene: dimm / 35404
• FlyBaseID: FBgn0023091
• Length: 390
• Species: Drosophila melanogaster
• Sequence 2: NP_000465.1
• Gene: TWIST1 / 7291
• HGNCID: 12428
• Length: 202
• Species: Homo sapiens
• Alignment Length: 193
• Identity: 56/193 - (29%)
• Similarity: 78/193 - (40%)
• Gaps: 56/193 - (29%)

  Fly    45 SSRPVRRATRRTSQLSNNTYDLEMTDSSS--------QSDDTSGGGGSSNGG------GSTTNTG 95
            ||.||..|   ...|||:..:.:.....|        :|...|.|||:..||      |.....|
Human     6 SSSPVSPA---DDSLSNSEEEPDRQQPPSGKRGGRKRRSSRRSAGGGAGPGGAAGGGVGGGDEPG 67

  Fly    96 HP---------SGCSLGGQGPSGRGRVQQASSGACPSTIAPNSTSSNSSNANGNASRRRKGALNA 151
            .|         :||..||....|.|   .:|.|..|.:.
Human    68 SPAQGKRGKKSAGCGGGGGAGGGGG---SSSGGGSPQSY-------------------------- 103

  Fly   152 KERNMRRLESNERERMRMHSLNDAFQSLREVIPHVEMERRLSKIETLTLAKNYIINLTHIILS 214
            :|...:|:.:|.|||.|..|||:||.:||::||.:..: :||||:||.||..||..|..::.|
Human   104 EELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQS 165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dimm	NP_523611.1	bHLH_TS_dimmed_like	157..216	CDD:381555	27/58 (47%)
TWIST1	NP_000465.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..105		28/130 (22%)
		bHLH_TS_TWIST1	98..174	CDD:381418	29/95 (31%)
		Sufficient for transactivation activity. /evidence=ECO:0000250	161..191		1/5 (20%)