DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dimm and BHLHE22

DIOPT Version :9

Sequence 1:	NP_001260674.1	Gene:	dimm / 35404	FlyBaseID:	FBgn0023091	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_689627.1	Gene:	BHLHE22 / 27319	HGNCID:	11963	Length:	381	Species:	Homo sapiens

Alignment Length:	279	Identity:	81/279 - (29%)
Similarity:	114/279 - (40%)	Gaps:	48/279 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 YNTDGHNGLSSESAEGSSRPVRRATRRTSQLSNNTYDLEMTDSSSQSDDTSGGGGSSNGGGSTTN 93
            |......|..:||:.|...|...:..|...:      |....:..::...:||||:....|.:..
Human   129 YGESASRGSVAESSGGEQSPDDDSDGRCELV------LRAGVADPRASPGAGGGGAKAAEGCSNA 187

  Fly    94 TGHPSGCSL--GGQGPSGRGRVQQASSGACPSTIAPNSTSSNSSNANGNASRRRKGALNAKERNM 156
            ..| .|.|:  ||.|..|.|.....|||....:   .|.|..||:::.::|::      :||:..
Human   188 HLH-GGASVPPGGLGGGGGGGSSSGSSGGGGGS---GSGSGGSSSSSSSSSKK------SKEQKA 242

  Fly   157 RRLESNERERMRMHSLNDAFQSLREVIP--HVEMERRLSKIETLTLAKNYIINLTHIILSKR--- 216
            .||..|.|||.|||.||||...||.|||  |....|:||||.||.||||||:.....:...|
Human   243 LRLNINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLV 307

  Fly   217 -----NEEAAALELNSGAVGGVLLSNL-------SSESGGPVASGIPANSNAATICFEDTLASGG 269
                 .:..:|..|.|.|......:.|       ...:|.|.::|:|    .|..|.|
Human   308 AYLNQGQAISAASLPSSAAAAAAAAALHPALGAYEQAAGYPFSAGLP----PAASCPE------- 361

  Fly   270 AFDCAILAATDGSLLNAAT 288
              .||:..:...||....|
Human   362 --KCALFNSVSSSLCKQCT 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dimm	NP_001260674.1	HLH	154..208	CDD:238036	32/55 (58%)
BHLHE22	NP_689627.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..94
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..154		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..242		18/63 (29%)
		HLH	248..302	CDD:197674	30/53 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3898
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810