Protein Alignment Mondo and Mlxipl

DIOPT Version :9

• Sequence 1: NP_001163032.1
• Gene: Mondo / 35402
• FlyBaseID: FBgn0032940
• Length: 1119
• Species: Drosophila melanogaster
• Sequence 2: XP_006504540.1
• Gene: Mlxipl / 58805
• MGIID: 1927999
• Length: 929
• Species: Mus musculus
• Alignment Length: 1171
• Identity: 291/1171 - (24%)
• Similarity: 427/1171 - (36%)
• Gaps: 416/1171 - (35%)

  Fly    71 IHSGQFMVSHFEAEEAQDDLEDDGEVKMLDPEDPGLGKPGEPTNTCRDVQLYVPQTVAHFSAMDQ 135
            ||||.||||...::......:.:|.|.:.|                     :.|::
Mouse    47 IHSGHFMVSSPHSDSLTRRRDQEGPVGLAD---------------------FGPRS--------- 81

  Fly   136 EGDESSMSMVTSHLEIETSLTKLFKCMNLAYSQKLTSPKWNHFKGVRLRWKDKIRLNNVIWRCWH 200
                           |:.:||.||:|::||||.||.||||.:|||::|..:|||||||.|||.|:
Mouse    82 ---------------IDPTLTHLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWY 131

  Fly   201 MQFIQKRRTPVCQFASPL---DVDIHSNPQTVVLEGKYWKRHSAVIKAEYRKWRRNYRSKATGCL 262
            :|::|:|::|||.|.:||   :.|.|..|:.|:|||.||||...|:..||.|||..|:.:..
Mouse   132 IQYVQRRKSPVCGFVTPLQGSEADEHRKPEAVILEGNYWKRRIEVVMREYHKWRIYYKKRLR--- 193

  Fly   263 TYDSKSELDFLE-------WSPLNDRNLMPDDW-------------------------------- 288
              .|..|.|||.       |.|       |:.|
Mouse   194 --KSSREGDFLAPKQVEGGWPP-------PERWCEQLFSSVVPVLLGGSEEEPGGRQLLDLDCFL 249

  Fly   289 --TTDTLFSAINVPFPFPDSREIA---RGAGIADFIQPSLGPLQPNLDDIDISFSDLIPTTRLPP 348
              .:||||:...   |.|.|.::.   ...|.||.|||.|.||||:|||. :..||.....|.|.
Mouse   250 SDISDTLFTMTQ---PSPSSLQLPPEDAYVGNADMIQPDLTPLQPSLDDF-MEISDFFTNYRPPQ 310

  Fly   349 VPEEGTDAEMLKNDEYCLSAIVGAPHTLYCNDSIMDVVNSSNNGAVNVDASMLELNTPINNVSYG 413
            .|                                    .|||.               |.:.|:|
Mouse   311 TP------------------------------------TSSNY---------------IESPSFG 324

  Fly   414 EVEQRFSVARQVQQSNNDSQLLGDSGSMSGRIHGGKHFGPASANDNNTNRCVINGRVAKSTQRPF 478
            .:.              ||  |..||.::..:.     .|||::.::
Mouse   325 PMA--------------DS--LFSSGILAPEMP-----SPASSSSSS------------------ 350

  Fly   479 RREPHNYDKAQPTMHQTNLYQQMLAEQQKNQQQQHVVVSSFQASQQQQLAQQQPFSAQATNAFNN 543
            ...||:        ..|.|       |.:|                           ..:...:.
Mouse   351 GMTPHS--------GNTRL-------QARN---------------------------SCSGPLDP 373

  Fly   544 QSFISSYADNYQHQQQLNVKVEPLHADVLSLLNDNAYNSIGYKPYPQFKKSASTGTFLNVPRQTQ 608
            ..|:||   .:...:....|:.|.......|            |:|...|..........|..|.
Mouse   374 NPFLSS---EFLLPEDPKTKIPPAPGPTPLL------------PFPTPVKVHGLEPCTPSPFPTM 423

  Fly   609 QQQSYLQQEPPQMQQSLPVGMGNQQILQLTRQQQVNNTQQQQHQSTVASLLQQQHQQQNHQQQQL 673
            .....|..|...:....|.
Mouse   424 APPPSLLPEESLLSARFPF---------------------------------------------- 442

  Fly   674 QTAVSSATWVS----PNTILPKEIYRSNSLPLNVSLNKLPDGRQLHHEQP-----FAVPKYHSKS 729
             |:...|..||    |.|.:|..  :....|:..|::.||.|    :.:|     |.||: ..:.
Mouse   443 -TSAPPAPGVSTLPAPTTFVPTP--QPGPGPVPFSVDHLPHG----YLEPVFGPHFTVPQ-GMQP 499

  Fly   730 KSRVRSNSMHQQHTSVVSAAGAGSSSLGA------HSC-SNLLVTQQMQQATSDPMLNSTLAQLL 787
            :.:..|.|...|..|..:.|.|.:|....      :.| :.||...:.:||...|.:..||.:..
Mouse   500 RCKPSSPSPGGQKASPPTLASATASPTATATARDNNPCLTQLLRAAKPEQALEPPTMPGTLLRPP 564

  Fly   788 TS-----------NSRLQTAVANSSSSNSPSVSAIATTNSNSNAPPVHYANVTSPLSVPVPTHQH 841
            .|           .||..|.....|.....:||.|  ..:.:..||           :|.||...
Mouse   565 ESPVRWWALGGEGQSRAFTPTLCPSPPQQDTVSEI--PRARAFFPP-----------IPAPTPPR 616

  Fly   842 SPKKSASL----PMAVNSALH-SPPLGS----KIHGIGLATANVGSNSLSLSPESTFHESQDSPL 897
            .|...|:|    .:.|..|.. |||..|    ::.|...:....|:.|:.|||
Mouse   617 PPPGPATLAPPRSLVVPKAERLSPPASSGSERRLSGDLNSIQPSGALSVHLSP------------ 669

  Fly   898 SPTTSLKFQPRDT----QRRAGHIHAEQKRRYNIKNGFDTLHALI------PQLQLNP------- 945
             |.|.|.....|.    .||..||.||||||:|||.||||||.|:      |.|:::|
Mouse   670 -PQTVLSRGRVDNNKMENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSPQPAMHTP 733

  Fly   946 ---------------------------NAKLSKAAMLQKGADHIKQLRQERNVLKDKIEALRMER 983
                                       .:::|||..|||.|::|..|:|||..::::.:.||.|.
Mouse   734 LESWNPSLDQHPTPAPRACQHRGPHWWRSQVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEI 798

  Fly   984 DELNNSLTHLHSILPANGAPVTRQGTEHVRQLYDIYVRYNTMNDWKFWILGLILEPLLASYTSTV 1048
            :|||.::......|||.|.|:|.|..:.:|.::|.|||..|:::||||:..:::.||..|:...|
Mouse   799 EELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMV 863

  Fly  1049 SSASLDELRRTAFLWVDQHCSLIDLRPAVTNKLKYLSMHTDIVSEPPSTLQEEVAKALQNSSGQH 1113
            |:|||..||:|:..|::|:|||..|||.|.|.|:.||..|.|::: ||.:.|:..:|:...:...
Mouse   864 STASLHSLRQTSLAWLEQYCSLPALRPTVLNSLRQLSTSTSILTD-PSLVPEQATRAVTEGTLGR 927

  Fly  1114 P 1114
            |
Mouse   928 P 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mondo	NP_001163032.1	HLH	909..969	CDD:238036	34/103 (33%)
Mlxipl	XP_006504540.1	PHA03247	<369..672	CDD:223021	74/397 (19%)
		bHLH_SF	683..798	CDD:381792	37/114 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835040
Domainoid	1	1.000	124	1.000	Domainoid score	I5508
eggNOG	1	0.900	-	-		E1_KOG3582
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	355	1.000	Inparanoid score	I2226
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003465
OrthoInspector	1	1.000	-	-		otm43149
orthoMCL	1	0.900	-	-		OOG6_104294
Panther	1	1.100	-	-	LDO	PTHR15741
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5458
SonicParanoid	1	1.000	-	-		X2831
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.870