Protein Alignment Mondo and MLXIPL

DIOPT Version :9

• Sequence 1: NP_001163032.1
• Gene: Mondo / 35402
• FlyBaseID: FBgn0032940
• Length: 1119
• Species: Drosophila melanogaster
• Sequence 2: XP_011514579.1
• Gene: MLXIPL / 51085
• HGNCID: 12744
• Length: 917
• Species: Homo sapiens
• Alignment Length: 1195
• Identity: 297/1195 - (24%)
• Similarity: 432/1195 - (36%)
• Gaps: 463/1195 - (38%)

  Fly    52 SASGSAEATADLLKAERESIHSGQFMVSHFEAEEAQDDLEDDGEVKMLDPEDPGLGKPGEPTNTC 116
            ||.|       ||::  :.||||.||||...::......:.:|.|   .|.|.|
Human    37 SAGG-------LLRS--QVIHSGHFMVSSPHSDSLPRRRDQEGSV---GPSDFG----------- 78

  Fly   117 RDVQLYVPQTVAHFSAMDQEGDESSMSMVTSHLEIETSLTKLFKCMNLAYSQKLTSPKWNHFKGV 181
                   |::                        |:.:||:||:|::||||.||.||||.:|||:
Human    79 -------PRS------------------------IDPTLTRLFECLSLAYSGKLVSPKWKNFKGL 112

  Fly   182 RLRWKDKIRLNNVIWRCWHMQFIQKRRTPVCQFASPL---DVDIHSNPQTVVLEGKYWKRHSAVI 243
            :|..:|||||||.|||.|::|::::|::|||.|.:||   :.|.|..|:.|||||.||||...|:
Human   113 KLLCRDKIRLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVV 177

  Fly   244 KAEYRKWRRNYRSKAT--------------------------GCLT-------------YDSKS- 268
            ..||.|||..|:.:.:                          |.||             .||.:
Human   178 MREYHKWRIYYKKRVSGGGPGRPQSFPPAAAGYRPPRKIPGKGILTPELAPLGPSIQSRADSATV 242

  Fly   269 --------------------ELDFL-------EWSPLNDRNLMPDDWTTDTLFSAINVPFPFPDS 306
                                |.|.|       .|.|       |:.|... |||:: ||....|.
Human   243 WPQRLLAASLPRGRLRKPSREDDLLAPKQAEGRWPP-------PEQWCKQ-LFSSV-VPVLLGDP 298

  Fly   307 REIARG------------------------------------AGIADFIQPSLGPLQPNLDDIDI 335
            .|...|                                    .|.||.|||.|.||||:|||. :
Human   299 EEEPGGRQLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDF-M 362

  Fly   336 SFSDLIPTTRL--PPVPEEGTDAEMLKNDEYCLSAIVGAPHTLYCNDSIMDVVNSSNNGAVNVDA 398
            ..||....:||  ||:|....:.                       .|...||:|
Human   363 DISDFFTNSRLPQPPMPSNFPEP-----------------------PSFSPVVDS---------- 394

  Fly   399 SMLELNTPINNVSYGEVEQRFSVARQVQQSNNDSQLLGDSGSMSGRIHGGKHFGPASANDNNTNR 463
                                                |..||::      |....|||:
Human   395 ------------------------------------LFSSGTL------GPEVPPASS------- 410

  Fly   464 CVINGRVAKSTQRPFRREPHNYDKAQPTMHQTNLYQQMLAEQQKNQQQQHVVVSSFQASQQQQLA 528
                                         ..|:|                        |...:|
Human   411 -----------------------------AMTHL------------------------SGHSRL- 421

  Fly   529 QQQPFSAQATNA----FNNQSFISSYADNYQHQQQLNVKVEP-------LHADVLSLLNDNAYNS 582
                   ||.|:    .::.:|:||   ::...:....::.|       ||
Human   422 -------QARNSCPGPLDSSAFLSS---DFLLPEDPKPRLPPPPVPPPLLH-------------- 462

  Fly   583 IGYKPYPQFKKSASTGTFLNVPRQTQQQQSYLQQEPPQMQQSLPVGMGNQQILQLTRQQQVNNTQ 647
                 ||...|..........|.......:.|.||.|......|.
Human   463 -----YPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPF-------------------- 502

  Fly   648 QQQHQSTVASLLQQQHQQQNHQQQQLQTAVSSATWVSPNTI------LPKEIYRSNSLPLNVSLN 706
                                       ..|..|..|||...      .|:.:......|..:.|
Human   503 ---------------------------PTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIEL- 539

  Fly   707 KLPDGRQLHHEQPFAVPKYHSKSKSRVRSNSMHQQHTSVVSAAGAGSS---SLGAHS-C-SNLLV 766
             ||    |.:.:|...|.: |..:.:..:.|...|..|..:.|.|.:|   :.|::: | :.||.
Human   540 -LP----LGYSEPAFGPCF-SMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLT 598

  Fly   767 TQQMQQATSDPMLNSTLAQLLTSNSRLQTAVANSSSSNSPSVSAIATTNSNSNAPPVHYANVTSP 831
            ..:.:||...|:::|||.:              |..|...:|.....|    ..||
Human   599 AAKPEQALEPPLVSSTLLR--------------SPGSPQETVPEFPCT----FLPP--------- 636

  Fly   832 LSVPVPTHQHSPKKSASL----PMAVNSA--LHSP-PLGSKIHGIGLATANVGSNSLSLSPESTF 889
              .|.||....|...|:|    |:.|..|  |..| |.||:....|..::..|..:||:
Human   637 --TPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSV------ 693

  Fly   890 HESQDSPLSPTTSLKFQP---RDTQRRAGHIHAEQKRRYNIKNGFDTLHALIPQLQLNPNAKLSK 951
               :.||..|..| :.:|   :...||..||.||||||:|||.||||||.|:..|...|:.|:||
Human   694 ---RVSPPQPILS-RGRPDSNKTENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSK 754

  Fly   952 AAMLQKGADHIKQLRQERNVLKDKIEALRMERDELNNSLTHLHSILPANGAPVTRQGTEHVRQLY 1016
            |..|||.|::|..|:|||..|:::.:.||.|.:|||.::......|||.|.|:|.|..:.:|.::
Human   755 ATTLQKTAEYILMLQQERAGLQEEAQQLRDEIEELNAAINLCQQQLPATGVPITHQRFDQMRDMF 819

  Fly  1017 DIYVRYNTMNDWKFWILGLILEPLLASYTSTVSSASLDELRRTAFLWVDQHCSLIDLRPAVTNKL 1081
            |.|||..|:::||||:..:::.||..|:...||:||:..||:|:..|:||:|||..|||.|.|.|
Human   820 DDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASVHTLRQTSLAWLDQYCSLPALRPTVLNSL 884

  Fly  1082 KYLSMHTDIVSEPPSTLQEEVAKAL 1106
            :.|...|.|::: |..:.|:..:|:
Human   885 RQLGTSTSILTD-PGRIPEQATRAV 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mondo	NP_001163032.1	HLH	909..969	CDD:238036	33/59 (56%)
MLXIPL	XP_011514579.1	ATG16	652..>793	CDD:285778	60/150 (40%)
		HLH	713..773	CDD:238036	34/59 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144936
Domainoid	1	1.000	129	1.000	Domainoid score	I5262
eggNOG	1	0.900	-	-		E1_KOG3582
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2211
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D263805at33208
OrthoFinder	1	1.000	-	-		FOG0003465
OrthoInspector	1	1.000	-	-		otm41078
orthoMCL	1	0.900	-	-		OOG6_104294
Panther	1	1.100	-	-	LDO	PTHR15741
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5458
SonicParanoid	1	1.000	-	-		X2831
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.880