DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mondo and Mlxip

DIOPT Version :9

Sequence 1:	NP_001163032.1	Gene:	Mondo / 35402	FlyBaseID:	FBgn0032940	Length:	1119	Species:	Drosophila melanogaster
Sequence 2:	XP_222162.5	Gene:	Mlxip / 304479	RGDID:	1560774	Length:	916	Species:	Rattus norvegicus

Alignment Length:	1119	Identity:	306/1119 - (27%)
Similarity:	452/1119 - (40%)	Gaps:	315/1119 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TGVGASASGSAEATADLLKA---------ERESIHSGQFMVSHFEAEEAQDDLEDDGEVKMLDPE 102
            :||..||...|.|.....:|         .::.||||.||||....|.......|...|.....:
  Rat    44 SGVATSARAHASAAPLPPRAGPGREEPPRRQQIIHSGHFMVSSPHREHPPKKGYDFDTVNKQTCQ 108

  Fly   103 DPGLGKPGEPTNTCRDVQLYVPQTVAHFSAMDQEGDESSMSMVTSHLEIETSLTKLFKCMNLAYS 167
            ....||    |::|                               ||.|:.||||||:||.||||
  Rat   109 TYSFGK----TSSC-------------------------------HLSIDASLTKLFECMTLAYS 138

  Fly   168 QKLTSPKWNHFKGVRLRWKDKIRLNNVIWRCWHMQFIQKRRTPVCQFASPL----DVDIHSNPQT 228
            .||.||||.:|||::|:|:|||||||.|||.|:||:::||:.|||.|.:||    |||.|..|:.
  Rat   139 GKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRRPEA 203

  Fly   229 VVLEGKYWKRHSAVIKAEYRKWRRNYRSKATGCLTYDSKS---ELDFLEWS----------PLND 280
            :..||||||....::..||.|||..::.:.......|..|   :.|.|.|.          |:.:
  Rat   204 ITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHKDEDLSSLAQDDDMLYWHKHGDGWKTPVPMEE 268

  Fly   281 RNLMPDDWT----TDTLFSAI--NVPFPFPDSREIARGAGIADFIQPSLGPLQPNLDDIDI--SF 337
            .:|:..|..    :|||||.:  :.|..:|:.||||. .|.||.|||.|.|||||||.:|.  .|
  Rat   269 DSLLDTDMLMSEFSDTLFSTLSSHQPVAWPNPREIAH-LGNADMIQPGLIPLQPNLDFMDTFEPF 332

  Fly   338 SDLIPTTR------LPPVPEEGTDAEMLKNDEYCLSAIVGAPHTLYCNDSIMDVVNSSNNGAVNV 396
            .:|..::|      |||                  ...|.||          |..:..:.|.:..
  Rat   333 QELFSSSRSIFGSMLPP------------------PTSVPAP----------DPSSPPSQGNILP 369

  Fly   397 DASMLELNTPINNVSYGEVEQRFSVARQVQQSNNDSQLLGDSGSMSGRIHGGKHFGPASANDNNT 461
            :.::..::.|                         :.|:..|.:             .|.:....
  Rat   370 NPALPPVSLP-------------------------NSLIASSAA-------------PSLDPTEG 396

  Fly   462 NRCVINGRVAKSTQRPFRREPHNYDKAQPTMHQTNLYQQMLAEQQKNQQQQHVVVSSFQASQQQQ 526
            ..|   .|.::|.. || .:|.::..::|                                   .
  Rat   397 QGC---ERTSQSVD-PF-IQPADFGPSEP-----------------------------------P 421

  Fly   527 LAQQQPFSAQATNAFNNQSFISSYADNYQHQQQLNVKVEPLHADVLSLLNDNAYNSIGYKPYPQF 591
            |:..|||....|...                    :...|..|.|.:.|             |..
  Rat   422 LSVPQPFLPVFTMTL--------------------LSPGPAPAPVPTAL-------------PLV 453

  Fly   592 KKSASTGTFLNVPRQTQQQQSYLQQEPPQMQQSLPVGMGNQQILQLTRQQQVNNTQQQQHQSTVA 656
            ...|.|   ||.|            .||...|                      ||.....||.:
  Rat   454 SPPAPT---LNPP------------TPPAFLQ----------------------TQTFAGVSTSS 481

  Fly   657 SLLQQQHQQQNHQQQQLQTAVSSATWVSPN--TILPKEIYRSNSLPLNVSLNKLPDGRQLHHEQP 719
            .::       .|......|..:|||..|.:  .::.......:..|..::|:.:|....:...||
  Rat   482 PVI-------THTASATLTHDASATTFSQSQGLVITAHHPTPSPSPCGLALSPIPQPPAVGPPQP 539

  Fly   720 ---FAVPKYHSKSKSRVRSNSMHQQHTSVVSAAGAGSSSLGAHSC--SNLLVTQQMQQA--TSDP 777
               |..||..|.:..|      |:|...:|.|....:.||...|.  :....|.|.|:.  ||.|
  Rat   540 HLTFIHPKPVSLTGVR------HKQPPKIVPAPKPEAVSLVLKSACIAPAAFTGQPQKVIMTSAP 598

  Fly   778 MLNSTLAQLLTSNSRLQTAVANSSSSNSPSVSAIATTNSNSNAPPVHYANVTSPLSVPVPTHQHS 842
            :             :.:..:|::.|.:|..:::.|.|.:         :.||..||... :.|.|
  Rat   599 L-------------KREGILASTVSPSSVVIASAAITRA---------SGVTEFLSHST-SSQPS 640

  Fly   843 PKKSASLPMAVNSALHSPPLGSKIHGIGLATANVGS----NSLSLSPESTFHESQDSPLSPTTSL 903
            |......|.||..||......: :||...|.|...|    ||...||..:  |...||.||..:.
  Rat   641 PASRLFSPSAVQDALVKGEQAA-LHGGPQAPATGSSRDCPNSGQASPCPS--EQSPSPQSPQNNC 702

  Fly   904 KFQPRD------TQRRAGHIHAEQKRRYNIKNGFDTLHALIPQLQLNPNAKLSKAAMLQKGADHI 962
            ..:..|      .:.|..||.||||||:||:.||:||::||.    |.:.:.|.|..|||..::|
  Rat   703 SGKSTDPKNVAALKNRQKHISAEQKRRFNIRMGFNTLNSLIS----NNSKQTSHAITLQKTMEYI 763

  Fly   963 KQLRQERNVLKDKIEALRMERDELNNSLTHLHSILPANGAPVTRQGTEHVRQLYDIYVRYNTMND 1027
            .:|:|||..::::...||.|.:|||.::.....:|||.|.||..:..:|::.::|.||:...:.:
  Rat   764 TKLQQERMQMQEEARRLREEIEELNTTIISCQQLLPATGVPVNCRQFDHMKDMFDEYVKSRILQN 828

  Fly  1028 WKFWILGLILEPLLASYTSTVSSASLDELRRTAFLWVDQHCSLIDLRPAVTNKLKYLSMHTDIVS 1092
            |||||..:|::||..|:...||::||:|..|||..|:||||||..|||.|.:.|:.||..|.|::
  Rat   829 WKFWIFSMIIKPLFESFKGMVSTSSLEEFHRTALSWLDQHCSLPVLRPMVLSTLRQLSTTTSILT 893

  Fly  1093 EPPSTLQEEVAKAL 1106
            : ||.|.|:.::|:
  Rat   894 D-PSQLPEQASEAV 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mondo	NP_001163032.1	HLH	909..969	CDD:238036	27/65 (42%)
Mlxip	XP_222162.5	HLH	716..770	CDD:238036	26/57 (46%)
Mlxip	XP_222162.5	bZIP	<757..798	CDD:304365	13/40 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338632
Domainoid	1	1.000	122	1.000	Domainoid score	I5511
eggNOG	1	0.900	-	-		E1_KOG3582
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2194
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D263805at33208
OrthoFinder	1	1.000	-	-		FOG0003465
OrthoInspector	1	1.000	-	-		otm45218
orthoMCL	1	0.900	-	-		OOG6_104294
Panther	1	1.100	-	-	O	PTHR15741
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2831
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.850