DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mondo and sre2

DIOPT Version :9

Sequence 1:	NP_001163032.1	Gene:	Mondo / 35402	FlyBaseID:	FBgn0032940	Length:	1119	Species:	Drosophila melanogaster
Sequence 2:	NP_595229.1	Gene:	sre2 / 2541044	PomBaseID:	SPBC354.05c	Length:	793	Species:	Schizosaccharomyces pombe

Alignment Length:	892	Identity:	165/892 - (18%)
Similarity:	268/892 - (30%)	Gaps:	339/892 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 SAINVPFPFPDSREIARGAGIADFIQPSLGPLQPNLDDIDISFSDLIPTTRLPPVPEEGTDAEML 359
            :||:.|....|......|:.|.||..||:         :..|.|...|.:.:|.|...|......
pombe    19 TAISNPTENADPSSYVDGSNIMDFKHPSI---------VSSSASSSYPISHVPSVGTRGIPRSYS 74

  Fly   360 KNDEYCLSAIVGAPHTLYCNDSIMDVVNSSNNGAVNVDASMLELNTPIN--NVSYGEVEQR--FS 420
            ....|        |:.:  |.:.||...:.|......|..||..|:..:  |...|.:|..  |:
pombe    75 MASAY--------PYQV--NSNSMDASTAFNLNQDVADKPMLARNSIDSSINTELGPLESNHWFT 129

  Fly   421 VARQVQQSNNDSQLLGDSGSMSGRIHGGKHFGPASANDNNTNRCVINGRVAKSTQRPFRREPHNY 485
            .|:.                     |..::   :|:.|.:.:...:...:..||.......||
pombe   130 QAQD---------------------HSRQY---SSSWDPSIDPFEVKNSLHDSTDLSITHHPH-- 168

  Fly   486 DKAQPTMHQTNLYQQMLAEQQKNQQQQHVVVSSFQASQQQQLAQQQPFSAQATNAFNNQSFI--- 547
               .|..||.|.::......|.||                             ....|..|:
pombe   169 ---LPINHQGNTWKHANESLQSNQ-----------------------------GPVPNTKFVGLE 201

  Fly   548 SSYADNYQHQQQLN--VKVEPLHADVLSLLNDNAYNSIGYKPYPQFKKSASTGTFLNVPRQTQQQ 610
            ::..|:|| |..:|  ||:|  .||....|.:               :|....||
pombe   202 TTQTDSYQ-QSSVNSVVKIE--EADATYALRE---------------ESGQFNTF---------- 238

  Fly   611 QSYLQQEPPQMQQSLPVGMGNQQILQLTRQQQVNNTQQQQHQSTVASLLQQQHQQQNHQQQQLQT 675
                            .|..|..|    ....:|....|..:....:|||...|..|:.....|.
pombe   239 ----------------TGAENPSI----SPHSLNPNFPQYTEKPALTLLQSPKQNSNYDTSNFQN 283

  Fly   676 AVSSATWVSPNTILP---KEIYRS-NSLPLNVS-------LNKLPDGRQLHHEQPFAVPKYHSKS 729
            :||.::....|..:|   |.|..| :::..|.|       .|...:|.:      |..|   :|.
pombe   284 SVSDSSMQFTNEGMPSPVKGIMSSDDAVAFNFSQYSTVYPQNAPENGNE------FETP---NKL 339

  Fly   730 KSRVRSNSMHQQHTSVVSAAGAGSSSLGAHSCSNLLVTQQMQQATSDPMLNSTLAQLLTSNSRLQ 794
            |..|.|..     .|:.|....|..   |..|                             |.:.
pombe   340 KRTVSSPC-----ASISSKRSYGDI---AQDC-----------------------------SYIS 367

  Fly   795 TAVANSSSSNSPSVSAIATTNS--NSNAPPVHYANVTSPLSVPVPTHQHSPKKSASLPMAVNSAL 857
            :.......|:|||.|:.:...|  :||:|                       .|:|...|:.|
pombe   368 SKTNGGGPSDSPSSSSTSVRGSVNDSNSP-----------------------ISSSATFAIQS-- 407

  Fly   858 HSPPLGSKIHGIGLATANVGSNSLSLSPESTFHESQDSPLSPTTSLKFQPRDTQRRAGHIHAEQK 922
                  :.:..:||:|                   |:..|||.:          :|:.|...|::
pombe   408 ------NGVEPVGLST-------------------QEQNLSPLS----------KRSAHNMIEKR 437

  Fly   923 RRYNIKNGFDTLHALIPQLQLNPNA---------------KLSKAAMLQKGADHIKQLRQERNVL 972
            .|.|:.:....|...:|.|:...|:               ||:||.:|.|..::||.| |.:|
pombe   438 YRSNLNDKIAELRDAVPTLRSGYNSTTADELKGTYVPLSRKLNKATILSKATEYIKSL-QSKN-- 499

  Fly   973 KDKIEALRMERDELNNSLTHLHSILPAN-------------GAPVTRQGTEHV------------ 1012
            |..||    |...|...|:...|::.|:             |.|....|..:|
pombe   500 KKLIE----ENKILQKRLSEYTSVIQASLTAPSQPASLSLLGPPGNTPGHRNVPPILKRSSIGTP 560

  Fly  1013 -RQLYDIYVRYNTMNDWKFWILGLILEPLLASY---TSTVSSASLDELRRTAFLWVDQHCSLIDL 1073
             :|.|.....:|..:           .|..:||   ...|:.:.:|.::..      .|.:..::
pombe   561 SQQAYFPDAPHNCHS-----------VPQNSSYPRPPMQVNRSPIDSMQTI------PHANFNEM 608

  Fly  1074 RPAVTNK--LKYLSMHTDIVSEPPSTLQEEVAKALQNSSGQHPNLHG 1118
            ..|.:::  |||                .:...|:.::|..||..:|
pombe   609 HNAYSSRYPLKY----------------SKSCNAVSHTSMMHPQEYG 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mondo	NP_001163032.1	HLH	909..969	CDD:238036	19/74 (26%)
sre2	NP_595229.1	HLH	427..496	CDD:278439	18/69 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910