Protein Alignment Mondo and MLXIP

DIOPT Version :9

• Sequence 1: NP_001163032.1
• Gene: Mondo / 35402
• FlyBaseID: FBgn0032940
• Length: 1119
• Species: Drosophila melanogaster
• Sequence 2: XP_006719353.1
• Gene: MLXIP / 22877
• HGNCID: 17055
• Length: 960
• Species: Homo sapiens
• Alignment Length: 1167
• Identity: 311/1167 - (26%)
• Similarity: 456/1167 - (39%)
• Gaps: 378/1167 - (32%)

  Fly    50 GASASGSAEATA-----------DLLKAERESIHSGQFMVSHFEAEEAQDDLEDDGEVKMLDPED 103
            ||:....|.|:|           :.....::.||||.||||....|.......|...|.....:.
Human    45 GAATPARAHASAAPPPPRAGPGREEPPRRQQIIHSGHFMVSSPHREHPPKKGYDFDTVNKQTCQT 109

  Fly   104 PGLGKPGEPTNTCRDVQLYVPQTVAHFSAMDQEGDESSMSMVTSHLEIETSLTKLFKCMNLAYSQ 168
            ...||    |::|                               ||.|:.||||||:||.||||.
Human   110 YSFGK----TSSC-------------------------------HLSIDASLTKLFECMTLAYSG 139

  Fly   169 KLTSPKWNHFKGVRLRWKDKIRLNNVIWRCWHMQFIQKRRTPVCQFASPL----DVDIHSNPQTV 229
            ||.||||.:|||::|:|:|||||||.|||.|:||:::||:.|||.|.:||    |||.|..|:.:
Human   140 KLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRRPEAI 204

  Fly   230 VLEGKYWKRHSAVIKAEYRKWRRNYRSKATGCLTYDSKS---ELDFLEW---------------S 276
            ..||||||....::..||.|||..::.:.......|..|   :.|.|.|               .
Human   205 TTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHKDEDLSSLVQDDDMLYWHKHGDGWKTPVPMEED 269

  Fly   277 PLNDRNLMPDDWTTDTLFSAI--NVPFPFPDSREIARGAGIADFIQPSLGPLQPNLDDIDI--SF 337
            ||.|.:::..:: :|||||.:  :.|..:|:.||||. .|.||.|||.|.|||||||.:|.  .|
Human   270 PLLDTDMLMSEF-SDTLFSTLSSHQPVAWPNPREIAH-LGNADMIQPGLIPLQPNLDFMDTFEPF 332

  Fly   338 SDLIPTTR------LP-----PVPEEGTDAEMLKNDEYCLSAIVGAPHTLYCNDSIMDVVNSSNN 391
            .||..::|      ||     |||:        .|:.....:|:  |.|.....|:.|
Human   333 QDLFSSSRSIFGSMLPASASAPVPD--------PNNPPAQESIL--PTTALPTVSLPD------- 380

  Fly   392 GAVNVDASMLELNTPINNVSYGEVEQRFSVARQVQQSNNDSQLLGDSGSMSGRIHGGKHFGPASA 456
                      .|..|....|...::::                            |.:|
Human   381 ----------SLIAPPTAPSLAHMDEQ----------------------------GCEH------ 401

  Fly   457 NDNNTNRCVINGRVAKSTQRPFRREPHNYDKAQPTMHQTNLYQQMLAEQQKNQQQQHVVVSSFQA 521
                |:|          |:.|| .:|.::..::|
Human   402 ----TSR----------TEDPF-IQPTDFGPSEP------------------------------- 420

  Fly   522 SQQQQLAQQQPFSAQATNAFNNQSFISSYADNYQHQQQLNVKVEPLHADVLSLLNDNAYNSIGYK 586
                .|:..|||....|....:.|                 ...|..:.||.|:
Human   421 ----PLSVPQPFLPVFTMPLLSPS-----------------PAPPPISPVLPLV----------- 453

  Fly   587 PYPQFKKSASTGTFLNVPRQTQQQQSYLQQEPPQMQQSLPVGMGNQQILQLTRQQQVNNTQQQQH 651
            |.|        .|.||.|            .||...|.......|:....:|.......|    |
Human   454 PPP--------ATALNPP------------APPTFHQPQKFAGVNKAPSVITHTASATLT----H 494

  Fly   652 QSTVASLLQQQ------HQQQNHQQQQLQTAVSSATWVSPNT---------ILPKEIYRSNSLPL 701
            .:...:..|.|      |       ....:|......:||.|         :.||.:..:...|
Human   495 DAPATTFSQSQGLVITTH-------HPAPSAAPCGLALSPVTRPPQPRLTFVHPKPVSLTGGRP- 551

  Fly   702 NVSLNKLPDGRQLHHEQPFAVPKYHSKSKSRVRSNSMHQQHTSVVSAAGAGSSSLGAHSCSNLLV 766
                      :|.|...|...|:          ..|:..::..:..||.:|.
Human   552 ----------KQPHKIVPAPKPE----------PVSLVLKNARIAPAAFSGQ------------- 583

  Fly   767 TQQMQQATSDP-----MLNSTLAQLLTSNSRLQTAVANSSSSNSPSV----SAIATTN--SNSNA 820
             .|....||.|     ||.||::|   ||    ..:|.::.:.:|.|    |:|..|:  ..:::
Human   584 -PQAVIMTSGPLKREGMLASTVSQ---SN----VVIAPAAIARAPGVPEFHSSILVTDLGHGTSS 640

  Fly   821 PPVHYANVTSPLSVPVPTHQHSP-KKSASLPMAVNSALHSPPLGSKIHGIGLATANVGSNSLSLS 884
            ||       :|:|...|:....| .|...:|      ||.......:.|......|.|..|...|
Human   641 PP-------APVSRLFPSTAQDPLGKGEQVP------LHGGSPQVTVTGPSRDCPNSGQASPCAS 692

  Fly   885 PESTFHESQDSPLSP--TTSLKFQPRDT-----QRRAGHIHAEQKRRYNIKNGFDTLHALIPQLQ 942
                  |...||.||  ..|.|..|::.     .|:..||.||||||:|||..||.|::||
Human   693 ------EQSPSPQSPQNNCSGKSDPKNVAALKQNRQMKHISAEQKRRFNIKMCFDMLNSLI---- 747

  Fly   943 LNPNAKL-SKAAMLQKGADHIKQLRQERNVLKDKIEALRMERDELNNSLTHLHSILPANGAPVTR 1006
             :.|:|| |.|..|||..::|.:|:|||..::::...||.|.:|||.::.....:|||.|.||||
Human   748 -SNNSKLTSHAITLQKTVEYITKLQQERGQMQEEARRLREEIEELNATIISCQQLLPATGVPVTR 811

  Fly  1007 QGTEHVRQLYDIYVRYNTMNDWKFWILGLILEPLLASYTSTVSSASLDELRRTAFLWVDQHCSLI 1071
            :..:|::.::|.||:..|:.:|||||..:|::||..|:...||::||:||.|||..|:||||||.
Human   812 RQFDHMKDMFDEYVKTRTLQNWKFWIFSIIIKPLFESFKGMVSTSSLEELHRTALSWLDQHCSLP 876

  Fly  1072 DLRPAVTNKLKYLSMHTDIVSEPPSTLQE---------EVAKALQNSSG-------QHPNLH 1117
            .|||:      |.|:.::.::.|....|.         ::.:.|:...|       :|.:||
Human   877 ILRPS------YRSLISEQLAAPWHQEQHRMLHLRQLLDLGRLLEAEGGIEHAAAAEHLHLH 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mondo	NP_001163032.1	HLH	909..969	CDD:238036	28/65 (43%)
MLXIP	XP_006719353.1	HLH	718..774	CDD:238036	28/60 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144935
Domainoid	1	1.000	129	1.000	Domainoid score	I5262
eggNOG	1	0.900	-	-		E1_KOG3582
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2211
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D263805at33208
OrthoFinder	1	1.000	-	-		FOG0003465
OrthoInspector	1	1.000	-	-		otm41078
orthoMCL	1	0.900	-	-		OOG6_104294
Panther	1	1.100	-	-	O	PTHR15741
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5458
SonicParanoid	1	1.000	-	-		X2831
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.880