DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mondo and Mlxip

DIOPT Version :9

Sequence 1:	NP_001163032.1	Gene:	Mondo / 35402	FlyBaseID:	FBgn0032940	Length:	1119	Species:	Drosophila melanogaster
Sequence 2:	NP_598678.2	Gene:	Mlxip / 208104	MGIID:	2141183	Length:	917	Species:	Mus musculus

Alignment Length:	1132	Identity:	311/1132 - (27%)
Similarity:	457/1132 - (40%)	Gaps:	340/1132 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TGVGASASGSAEATADLLKA---------ERESIHSGQFMVSHFEAEEAQDDLEDDGEVKMLDPE 102
            :||..||...|.|.....:|         .::.||||.||||....|.......|...|.....:
Mouse    44 SGVATSARAHASAAPLPPRAGPGREEPPRRQQIIHSGHFMVSSPHREHPPKKGYDFDTVNKQTCQ 108

  Fly   103 DPGLGKPGEPTNTCRDVQLYVPQTVAHFSAMDQEGDESSMSMVTSHLEIETSLTKLFKCMNLAYS 167
            ....||    |::|                               ||.|:.||||||:||.||||
Mouse   109 TYSFGK----TSSC-------------------------------HLSIDASLTKLFECMTLAYS 138

  Fly   168 QKLTSPKWNHFKGVRLRWKDKIRLNNVIWRCWHMQFIQKRRTPVCQFASPL----DVDIHSNPQT 228
            .||.||||.:|||::|:|:|||||||.|||.|:||:::||:.|||.|.:||    |||.|..|:.
Mouse   139 GKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRRPEA 203

  Fly   229 VVLEGKYWKRHSAVIKAEYRKWRRNYRSKATGCLTYDSKS---ELDFLEWS----------PLND 280
            :..||||||....::..||.|||..::.:.......|..|   :.|.|.|.          |:.:
Mouse   204 ITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHKDEDLSSLAQDDDMLYWHKHGDGWKTPVPMEE 268

  Fly   281 RNLMPDDWT----TDTLFSAI--NVPFPFPDSREIARGAGIADFIQPSLGPLQPNLDDIDI--SF 337
            .:|:..|..    :|||||.:  :.|..:|:.||||. .|.||.|||.|.|||||||.:|.  .|
Mouse   269 DSLLDTDMLMSEFSDTLFSTLSSHQPVAWPNPREIAH-LGNADMIQPGLIPLQPNLDFMDTFEPF 332

  Fly   338 SDLIPTTR------LPPVPEEGTDAEMLKNDEYCLSAIVGAPHTLYCNDSIMDVVNSSNNGAVNV 396
            .||..::|      |||                        |.:|...|
Mouse   333 QDLFSSSRSIFGSMLPP------------------------PSSLPAAD---------------- 357

  Fly   397 DASMLELNTPINNVSYGEVEQRFSVARQVQQSNNDSQLLGDSGSMSGRIHGGKHFGPASANDNNT 461
                                          .|:..||         |.|.......|||
Mouse   358 ------------------------------PSSPPSQ---------GNILPNTALPPAS------ 377

  Fly   462 NRCVINGRVAKSTQRPFRREPHNYDKAQPTMHQTNLYQQMLAEQQKNQQQQHVVVSSFQAS---- 522
               :.|..:..|              |.|::..|        |.|..::....|....|.:
Mouse   378 ---LPNSLITSS--------------AAPSLDPT--------EGQGCERTSQTVDPFIQPADFGP 417

  Fly   523 QQQQLAQQQPFSAQATNAFNNQSFISSYADNYQHQQQLNVKVEPLHADVLSLLNDNAYNSIGYKP 587
            .:..|:..|||                                 |....::||      |.|..|
Mouse   418 SEPPLSVPQPF---------------------------------LPVFTMTLL------SPGPAP 443

  Fly   588 YP---QFKKSASTGTFLNVPRQTQQQQSYLQQEPPQ----MQQSLPVGMGNQQILQLTRQQQVNN 645
            .|   ......|....||.|    ...::||   ||    :.:|.||         :|.......
Mouse   444 APVPTALPLVPSPAPTLNPP----TPPAFLQ---PQKFAGVSKSTPV---------ITHTASATL 492

  Fly   646 TQQQQHQSTVASLLQQQHQQQNHQQQQLQTAVSSATWVSPNTILPKEIYRSNSLPLNVSLNKLPD 710
            |    |.::..:..|.            |..|.:|...:|           :|.|..::|:.:|.
Mouse   493 T----HDASATTFSQN------------QGLVITAHHPTP-----------SSSPCALALSPVPQ 530

  Fly   711 GRQLHHEQP---FAVPKYHSKSKSRVRSNSMHQQHTSVVSAAGAGSSSLG-AHSC-SNLLVTQQM 770
            ...:...||   |..||..|.:..|      |:|...:|.|......||. .::| :....:.|.
Mouse   531 PPAVGPPQPHLTFIHPKPVSLTGVR------HKQPPKIVPAPKPEPVSLVLKNACIAPAAFSGQP 589

  Fly   771 QQA--TSDPMLNSTLAQLLTSNSRLQTAVANSSSSNSPSVSAIATTNSNSNAPPVHYANVTSPLS 833
            |:.  ||.|:....:  |.::.|.....:|:::.:.:..|:...:.:::|...||  :.:.||.:
Mouse   590 QKVIMTSAPLKREGI--LASTVSPSNVVIASAAITRASGVTEFLSHSTSSQPSPV--SRLFSPST 650

  Fly   834 V--------PVPTHQHSPKKSASLPMAVNSALHSPPLGSKIHGIGLATANVGSNSLSLSPESTFH 890
            |        .|..|..||:    :| |..|:...|                  ||...||..:
Mouse   651 VQDSLVKGEQVSLHGGSPQ----VP-ATGSSRDCP------------------NSGQASPCPS-- 690

  Fly   891 ESQDSPLSPTTSLKFQPRD------TQRRAGHIHAEQKRRYNIKNGFDTLHALIPQLQLNPNAKL 949
            |...||.||..:...:..|      .:.|..||.||||||:||:.||:||::||.    |.:.:.
Mouse   691 EQSPSPQSPQNNCSGKSTDPKNVAALKNRQKHISAEQKRRFNIRMGFNTLNSLIS----NNSKQT 751

  Fly   950 SKAAMLQKGADHIKQLRQERNVLKDKIEALRMERDELNNSLTHLHSILPANGAPVTRQGTEHVRQ 1014
            |.|..|||..::|.:|:|||..::::...||.|.:|||.::.....:|||.|.||..:..:|:|.
Mouse   752 SHAITLQKTMEYITKLQQERMQMQEEARRLREEIEELNTTIISCQQLLPATGVPVNCRQLDHMRD 816

  Fly  1015 LYDIYVRYNTMNDWKFWILGLILEPLLASYTSTVSSASLDELRRTAFLWVDQHCSLIDLRPAVTN 1079
            ::|.||:..|:.:|||||..:|::||..|:...||::||:|..|||..|:||||||..|||.|.:
Mouse   817 MFDEYVKSRTLQNWKFWIFSMIIKPLFESFKGMVSTSSLEEFHRTALSWLDQHCSLPVLRPMVLS 881

  Fly  1080 KLKYLSMHTDIVSEPPSTLQEEVAKAL 1106
            .|:.||..|.|::: ||.|.|:.::|:
Mouse   882 TLRQLSTTTSILTD-PSQLPEQASEAV 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mondo	NP_001163032.1	HLH	909..969	CDD:238036	27/65 (42%)
Mlxip	NP_598678.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72		7/27 (26%)
		Required for cytoplasmic localization. /evidence=ECO:0000250\|UniProtKB:Q9HAP2	73..327		111/289 (38%)
		Transactivation domain. /evidence=ECO:0000269\|PubMed:11073985	322..445		41/271 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..402		21/164 (13%)
		FLO_LFY	425..>476	CDD:279962	18/96 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..711		24/105 (23%)
		HLH	717..771	CDD:238036	26/57 (46%)
		bZIP	<758..799	CDD:304365	13/40 (33%)
		Leucine-zipper	767..788		7/20 (35%)
		Mediates heterotypic interactions between MLXIP and MLX and is required for cytoplasmic localization. /evidence=ECO:0000250\|UniProtKB:Q9HAP2	830..879		27/48 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..917		4/11 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835039
Domainoid	1	1.000	124	1.000	Domainoid score	I5508
eggNOG	1	0.900	-	-		E1_KOG3582
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	355	1.000	Inparanoid score	I2226
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D263805at33208
OrthoFinder	1	1.000	-	-		FOG0003465
OrthoInspector	1	1.000	-	-		otm43149
orthoMCL	1	0.900	-	-		OOG6_104294
Panther	1	1.100	-	-	O	PTHR15741
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5458
SonicParanoid	1	1.000	-	-		X2831
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.880