Protein Alignment Mondo and mml-1

DIOPT Version :10

• Sequence 1: NP_610105.2
• Gene: Mondo / 35402
• FlyBaseID: FBgn0032940
• Length: 1119
• Species: Drosophila melanogaster
• Sequence 2: NP_498631.2
• Gene: mml-1 / 176050
• WormBaseID: WBGene00003378
• Length: 1009
• Species: Caenorhabditis elegans
• Alignment Length: 1183
• Identity: 280/1183 - (23%)
• Similarity: 466/1183 - (39%)
• Gaps: 327/1183 - (27%)

  Fly    71 IHSGQFMVSHFEAEEAQDDLEDDGEVKMLDPEDPGLGKPGEPTNTCRDVQLYVPQTVAHFSAMDQ 135
            ||||.||.|:...:..||:.|:|.||.:::.:|.               .:....:|.|   .::
 Worm     7 IHSGHFMCSNPHDDLVQDEDEEDVEVDVVEDDDK---------------SMEASSSVHH---KNK 53

  Fly   136 EGDESSMSMV------TSHLEIETSLTKLFKCMNLAYSQKLTSPKWNHFKGVRLRWKDKIRLNNV 194
            ..||..::..      |..:.|:.||.||.||:.:||: |:|:|||..|||:||.||.::|||||
 Worm    54 ALDEKPVTFYKFGVGKTQSIAIDVSLNKLNKCIKVAYN-KMTTPKWKDFKGLRLHWKQRVRLNNV 117

  Fly   195 IWRCWHMQFIQKR----RTPVCQFASPLDVDIHSNPQTVVLEGKYWKRHSAVIKAEYRKWRRNYR 255
            |||.::::|.:|:    :.|.|.||.|.|...|...:..::||.||||....:.|:|::||  .|
 Worm   118 IWRAYYIEFRKKQPEKPKKPFCYFAVPDDDTTHQKIEGSIVEGMYWKRKMEGVCAQYKRWR--IR 180

  Fly   256 SK---------------------ATGCLTYDSK---------SELDFLEWSPLNDRNLMP----- 285
            ||                     .||.|....|         |:|...|......|:..|
 Worm   181 SKHNLVTDKGGMVATCSSTSVSSMTGELKRKRKHTVPKETIESKLRSYEPPVKLQRSQTPKHTIS 245

  Fly   286 ----------DDWTTDTLFSAINVPFPFPDSREIARGAGIADFIQPSLGPLQPNLDDIDISFSDL 340
                      |:..||...::::.|:.|||.|::..|.. ||.:||.|.||||.::||.:|..|.
 Worm   246 DEFAWDFDDLDNVFTDDFLNSLSEPYMFPDPRDVYSGNN-ADIMQPGLLPLQPTIEDIMMSLGDD 309

  Fly   341 IPTTRLPPVPEEGTDAEMLKNDEYCLSAIVGAPHTLYCNDSIMDVVNSSNNGAVNVDASMLELNT 405
            :|.:  ||...:........||:..:||           ..|..:..|:::     .||:.::
 Worm   310 MPDS--PPFHNDRDTMRTPTNDQPSISA-----------QQIPQMRRSASS-----SASLHQM-- 354

  Fly   406 PINNVSYGEVEQRFSVARQVQQSNNDSQLLGDSGSMSGRIHGGKHFGPASANDNNTNRCVINGRV 470
               .|:..:.:....:::..||..:..|:
 Worm   355 ---QVAQAQAQSISQISQPSQQLQHQIQI------------------------------------ 380

  Fly   471 AKSTQRPFRREPHNY--------DKAQPTMHQTNLYQQMLAEQQKNQQQQHVVVSSFQASQQQQL 527
                |:|....||.:        .:..||...:.:..|||                 ..||....
 Worm   381 ----QQPVAARPHEFMASSIMMDYRLMPTRQSSAITSQML-----------------MLSQSAST 424

  Fly   528 AQQQPFSAQATNAFNNQSF--ISSYADNYQHQQQLNVKVEPLHADVLSLLNDNAYNSIGY-KPYP 589
            ...||..|.:|:...|.||  |.:...|..|                          :|: ..:.
 Worm   425 LSSQPQYATSTHYSTNNSFLPIRNTMTNQHH--------------------------LGHTSQHS 463

  Fly   590 QFKKSASTGTFLNVPRQTQQQQSYLQQ----EPPQMQQSLPVGMGNQQILQLTRQQQVNNTQQQQ 650
            .:.|...:...:::|.|:..::....|    .||.....||                   ||...
 Worm   464 PWNKQQQSNFLVSLPHQSHVERILNNQPPLVPPPSRSNLLP-------------------TQNDP 509

  Fly   651 HQSTVASLLQQQHQQQNHQQQQLQTAVSSATWV-SPNTILPKEIYRSNSLPLNVSLNKLPDGRQL 714
            :........|...|.|:|....   |.|.:.|: ||.|       .|...||:|: ..||...|.
 Worm   510 YLPQFLQSTQPTPQPQSHDPMM---APSRSWWLDSPLT-------ASVQSPLSVA-TPLPLANQT 563

  Fly   715 HHEQPFAVPKYHSKSKSRVRSNSMHQQHTSVVSAAG-----AGSSSLGAHSCSNL-----LVTQQ 769
            ..:.|..                      .::.:|.     .|:::.|....|..     .::|:
 Worm   564 GPQTPLG----------------------QLIGSADNGFLFGGNNTPGGFKMSGTTSGVPTLSQR 606

  Fly   770 MQQ----ATS----------DPMLNSTLAQL--------LTSNSRLQTAVANSS------SSNSP 806
            ::|    .||          :.:..|..:|.        ::|.|||:|:..|.|      ...||
 Worm   607 LEQPPISRTSTIFGNVENKPERIFTSLTSQNTPTPSPLDISSLSRLRTSSLNESWKMSHIVEGSP 671

  Fly   807 SVSAIA---TTNSNSNAPPVHYANVTSPLSVPVPTHQHSPK----KSASLPMAVNSALHSPPLG- 863
            :..|.|   ||..:....|....:::.|.||||...||.||    .|||.......|..:|.:.
 Worm   672 TYQAFAASVTTKPSILESPSTSGDISGPASVPVQASQHPPKIITPPSASSKRKEQEAAMAPLVNR 736

  Fly   864 SKIHGIGLATANV--------GSNSLSLSPESTFHESQDSPL-----SPTTSLKFQPRDT----- 910
            .:...:.|....:        |.:.|..:|......:::.||     |...|::.|..|:
 Worm   737 QQSCDVNLLNGKMAVKVEEKSGRHYLPTTPTELKEVTKEEPLLMSAPSSVKSMRRQAPDSTLHPE 801

  Fly   911 -QRRAGHIHAEQKRRYNIKNGFDTLHALIPQLQLNPNAKLSKAAMLQKGADHIKQLRQERNVLKD 974
             ::|..|:||||.||..:|:|||.|..:||.| .:...|.:.|.:|.|.||||::|:.|:.....
 Worm   802 ERKRILHLHAEQNRRSALKDGFDQLMDIIPDL-YSGGVKPTNAVVLAKSADHIRRLQAEKWDKTQ 865

  Fly   975 KIEALRMERDELNNSLTHLHSILPANGAPVTRQGTEHVRQL---YDIYVRYNTMNDWKFWILGLI 1036
            ||:..:.:.::||..:|.|.|.||.:.||.:....:....|   :|.||:.....:|:||::..:
 Worm   866 KIDEAKAKIEKLNQKITSLQSNLPQSSAPSSSSQVDSKTSLETFFDRYVKEGAKKNWRFWVMSQM 930

  Fly  1037 LEPLLA----SYTSTVS--SASLDELRRTAFLWVDQHCSLIDLRPAVTNKLKYLSMHTDIVSEPP 1095
            |:|:..    |:.|:|:  |:|.:|:..:...|::::....:|||..:..|..|:.::.|::| |
 Worm   931 LKPICVTQTNSFASSVAGDSSSRNEVAASCSDWLNKNWKATELRPLASTLLVSLATNSSILAE-P 994

  Fly  1096 STLQEEVAKALQN 1108
            .||.:.|.:.|:|
 Worm   995 DTLPDYVMQQLKN 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mondo	NP_610105.2	NES2-NLS_ChREBP-like	151..260	CDD:439286	51/133 (38%)
		bHLHzip_MLXIP_like	910..982	CDD:381411	28/77 (36%)
mml-1	NP_498631.2	NES2-NLS_ChREBP-like	74..189	CDD:439286	51/117 (44%)
		bHLHzip_Mlx_like	803..874	CDD:381410	28/71 (39%)