Protein Alignment Mondo and mlxipl

DIOPT Version :10

• Sequence 1: NP_610105.2
• Gene: Mondo / 35402
• FlyBaseID: FBgn0032940
• Length: 1119
• Species: Drosophila melanogaster
• Sequence 2: XP_004911819.2
• Gene: mlxipl / 101733810
• XenbaseID: XB-GENE-940172
• Length: 815
• Species: Xenopus tropicalis
• Alignment Length: 1149
• Identity: 293/1149 - (25%)
• Similarity: 421/1149 - (36%)
• Gaps: 424/1149 - (36%)

  Fly    48 GVGASASGSAEATADL------LKAERESIHSGQFMVS--HFEAEEAQDDLEDDGEVKMLDPEDP 104
            |.|.:...|:.|.:|.      |....:.||||.||||  |.:.:..:.:|:
 Frog     3 GCGTNQLRSSNADSDSDSDCEGLGPRHQIIHSGHFMVSSPHGDDKHRRSELQ------------- 54

  Fly   105 GLGKPGE-PTNTCRDVQLYVPQTVAHFSAMDQEGDESSMSMVTSHLEIETSLTKLFKCMNLAYSQ 168
               :||. |..|                                   |:.:||:||:||:||||.
 Frog    55 ---RPGNLPAGT-----------------------------------IDPTLTRLFECMSLAYSG 81

  Fly   169 KLTSPKWNHFKGVRLRWKDKIRLNNVIWRCWHMQFIQKRRTPVCQFASPL---DVDIHSNPQTVV 230
            ||.||||.:|||:||.|:|||||||.|||.|::|:|:||:||||.|.:||   :.|.|..|:.||
 Frog    82 KLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYLQYIEKRKTPVCGFVTPLTGSEGDDHRKPEAVV 146

  Fly   231 LEGKYWKRHSAVIKAEYRKWRRNYRSKAT--------------------------GC-------- 261
            |||.||||....:..||.|||..|:.:..                          ||
 Frog   147 LEGNYWKRRIEAVMKEYNKWRIYYKKRLRKLHQDGNKSFNEQKSAPTWRCSQVYYGCPRLEDICG 211

  Fly   262 ----LTYDSKSELDFLEWSPLNDRNLMPDDWTTDTLFS---AINVPFPFPDSREIARGAGIADFI 319
                :.||    ||:.    |.|        .:||||:   .:...:..||...    ||.:|.|
 Frog   212 TEEDMLYD----LDYF----LTD--------ISDTLFTTTHGMQNAYQSPDYDY----AGNSDMI 256

  Fly   320 QPSLGPLQPNLDD-IDIS--FSDLIPTTRLPPVPEEGTDAEMLKNDEYCLSAIVGAPHTLYCNDS 381
            ||.|...||..|| :||:  ||.  |.|:..||         ...::.|.|
 Frog   257 QPGLSTFQPTPDDFVDITDFFSG--PRTQQLPV---------YFQEQNCFS-------------- 296

  Fly   382 IMDVVNSSNNGAVNVDASMLELNTPINNVSYGEVEQRFSVARQVQQSNNDSQLLGDSGSMSGRIH 446
                  |.|.|       :...:.|....:...:.|.:|
 Frog   297 ------SYNEG-------ITSQHPPAAAAACQRIPQPYS-------------------------- 322

  Fly   447 GGKHFGPASANDNNTNRCVINGRVAKSTQRPFRREPHNYDKAQPTMHQTNLYQQMLAEQQKNQQQ 511
               |||..|.:      |..:..::.|...  .|.|....:|:|                ||...
 Frog   323 ---HFGSKSES------CFASALISPSYAS--ARVPCVSPRAEP----------------KNLPH 360

  Fly   512 QHVVVSSFQASQQQQLAQQQPFSAQATNAFNNQSFISSYADNYQHQQQLNVKVEPLHADVLSLLN 576
            ..|....|.|.                            .|::..:|.|.:
 Frog   361 YPVSCDEFNAD----------------------------CDSFPQEQSLTM-------------- 383

  Fly   577 DNAYNSIGYKPYPQFKKSASTGTFLNVPRQTQQQQSYLQQEPPQMQQSLPVGMGNQQILQLTRQQ 641
                                                      |.:.|:||  |.|..||......
 Frog   384 ------------------------------------------PCISQNLP--MQNADILFPQVSC 404

  Fly   642 QVNNTQQQQHQSTVASLLQQQHQQQNHQQQQLQTAVSSATWVSPNTILPKEIYRSNSLPLNVSLN 706
            ..||......:|::..     |....|                           ::|.||
 Frog   405 PKNNYSGSVTESSILG-----HTAPTH---------------------------ADSYPL----- 432

  Fly   707 KLPDGRQLHHEQPFAVPKYHSKSKSRVRSNSMHQQHTSVVSAAGAGSSSLGAHSCSNLLVTQQMQ 771
             ..:...|.....|:|||                                   .|.:|     ..
 Frog   433 -YSENSSLEASHIFSVPK-----------------------------------QCGSL-----AN 456

  Fly   772 QATSDPMLNSTLAQLLTSNSRLQTAVANSSSSNSPS--VSAIATTNSNSNAP---PVHYANVTSP 831
            .....|.:.:|......|.|.:.....:.||:|:||  ::..::|......|   |...|:...|
 Frog   457 NKARKPAVETTEQVTCGSPSHISVKAKSDSSTNAPSCGLTGPSSTTGTGLDPLCFPGIAASAVQP 521

  Fly   832 LSVPVPTHQHSPKKSASLPMAV-NSALHSPPLGSKIHGIGLATANVGSNSLSLSPESTFHESQDS 895
            |:.|......||......|..: .|.:.||...:.|.|      :...:..||.|::       .
 Frog   522 LAPPTIQCNFSPSPPPLPPPPIFVSPMFSPQSNNSISG------STTRSCSSLQPKT-------E 573

  Fly   896 PLSPTT---------SLK---FQ----------PRDTQRRAGHIHAEQKRRYNIKNGFDTLHALI 938
            .||||:         ||.   ||          .:...||..||.||||||.|||.||||||.|:
 Frog   574 RLSPTSVCAGGEHKDSLSVPCFQSSTSWVRTGCKKGDSRRITHISAEQKRRCNIKIGFDTLHNLV 638

  Fly   939 PQLQLNPNAKLSKAAMLQKGADHIKQLRQERNVLKDKIEALRMERDELNNSLTHLHSILPANGAP 1003
            ..|....:.|||||..|||.|:::.:|:|||..|:::.:.||.:..|||:|::.....|||:|.|
 Frog   639 TTLHGQHSNKLSKATTLQKTAEYVYKLQQERAQLQEEAQHLRCQIQELNDSISLCQQQLPASGVP 703

  Fly  1004 VTRQGTEHVRQLYDIYVRYNTMNDWKFWILGLILEPLLASYTSTVSSASLDELRRTAFLWVDQHC 1068
            :|:|..:.:|||:..||:..|:.:||||:..||:.||..|:..|||:|||.:||:|:..|:||||
 Frog   704 MTQQRFQLMRQLFQNYVQMRTLQNWKFWLFSLIIRPLFESFNRTVSTASLADLRQTSLEWLDQHC 768

  Fly  1069 SLIDLRPAVTNKLKYLSMHTDIVSEPPSTLQEEVAKALQNSSGQ 1112
            ||..|||:|.:.|..||..|.|:|: |:.|.|:..:|:.....:
 Frog   769 SLPALRPSVLSSLCQLSTSTSILSD-PTLLPEQALQAVTRQDNE 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mondo	NP_610105.2	NES2-NLS_ChREBP-like	151..260	CDD:439286	63/137 (46%)
		bHLHzip_MLXIP_like	910..982	CDD:381411	37/71 (52%)
mlxipl	XP_004911819.2	NES2-NLS_ChREBP	63..178	CDD:439287	64/149 (43%)
		bHLHzip_MLXIPL	608..683	CDD:381532	37/74 (50%)