Protein Alignment Mondo and mlxip

DIOPT Version :9

• Sequence 1: NP_001163032.1
• Gene: Mondo / 35402
• FlyBaseID: FBgn0032940
• Length: 1119
• Species: Drosophila melanogaster
• Sequence 2: NP_001090682.1
• Gene: mlxip / 100036655
• XenbaseID: XB-GENE-990525
• Length: 873
• Species: Xenopus tropicalis
• Alignment Length: 1118
• Identity: 306/1118 - (27%)
• Similarity: 445/1118 - (39%)
• Gaps: 353/1118 - (31%)

  Fly    63 LLK----AERESIHSGQFMVSHFEAEEAQDDLEDDGEVKMLDPEDPGLGKPGEPTNTCRDVQLYV 123
            |||    :|.:.||||.||||...:|.......|...|.....:....||    |::|
 Frog    33 LLKKSDSSEAQIIHSGHFMVSSPHSEHPPKKGYDFDTVNEQACQTYSFGK----TSSC------- 86

  Fly   124 PQTVAHFSAMDQEGDESSMSMVTSHLEIETSLTKLFKCMNLAYSQKLTSPKWNHFKGVRLRWKDK 188
                                    ||.|:.|||||.:||.||||.||.||||.:|||::|:|:||
 Frog    87 ------------------------HLSIDASLTKLLECMTLAYSGKLVSPKWKNFKGLKLQWRDK 127

  Fly   189 IRLNNVIWRCWHMQFIQKRRTPVCQFASPLDVDI----HSNPQTVVLEGKYWKRHSAVIKAEYRK 249
            |||||.|||.|::|:|:||:.|||.|.:|||..:    |..|:.:..:||||||...::..||.|
 Frog   128 IRLNNAIWRAWYLQYIEKRKNPVCNFVTPLDASVYFEEHRRPEAIATDGKYWKRRIEIVVREYHK 192

  Fly   250 WR-------RNYRSKATGCLTYDS-----KSELDF------LEWSPLNDRNLMPDDWTTDTLFSA 296
            ||       :.::.:....|..|.     ||.:|.      :|..||.|..::..: .:|||||.
 Frog   193 WRTYFKKRLQKHKDEDLSSLVKDDDIVPWKSTVDGRDTPVPMEEEPLLDMEMLMAE-ISDTLFST 256

  Fly   297 INVPFPFPDSREIARGAGIADFIQPSLGPLQPNLDDIDI--SFSDLIPTTRLPPVPEEGTDAEML 359
            |......|  :|||. ||.||.|||.|.|||||||.:|.  ||.|:..::|||.
 Frog   257 IYSHQHNP--KEIAH-AGNADMIQPELFPLQPNLDLMDTFESFQDIFSSSRLPS----------- 307

  Fly   360 KNDEYCLSAIVGAPHTLYCNDSIMDVVNSSNNGAVNVDASMLELNTPINNVSYGEVEQRFSVARQ 424
                       |.    :.|       ::||..||.:..:.|...:|::..|       ...:..
 Frog   308 -----------GG----FFN-------STSNVSAVPLSDAPLRPCSPVSQTS-------ALPSST 343

  Fly   425 VQQSNNDSQLLGDSGSMSGRIHGGKHFGPASANDNNTNRCVINGRVAKSTQRPFRREPHNYDKAQ 489
            :...|.|.:|:...|..|        ..|.                     |..|||
 Frog   344 LAPVNLDEELIPSPGPPS--------IVPV---------------------REVRRE-------- 371

  Fly   490 PTMHQTNLYQQMLAEQQKNQQQQHVVVSSFQASQQQQLAQQQPFSAQATNAFNNQSFISSYADNY 554
                                          :|:....|:     ::|....||:::.|||
 Frog   372 ------------------------------RAASVGSLS-----TSQGPVKFNSETSISS----- 396

  Fly   555 QHQQQLNVKVEPLHADVLSLLNDNAYNSIGYKPYPQFKKSASTGTFLNVPRQTQQQQSYLQQEPP 619
            ||.   .|.|.|                   .|.|.|:..|::.   |||             |.
 Frog   397 QHG---FVPVFP-------------------PPVPLFQTPAASP---NVP-------------PA 423

  Fly   620 QMQQSLPVGM---GNQQILQLTRQQQVNNTQQQ--QHQSTVASLLQQQHQQQNHQQQQLQTAVSS 679
            ....|||..:   ||:  ..|.....:.:|...  .|..:..:..|.|:.....|||
 Frog   424 PSLDSLPTFITKDGNK--FPLCNTSVITHTASPTLTHNPSATTFSQSQNLILTTQQQ-------- 478

  Fly   680 ATWVSPNTILPKEIYRSNSLPLNVSLNKLPDGRQLHHEQPFAVPKYHSKSKSRVRSNSMHQQHTS 744
                               :|.|:|:            |...:|:           .:..|.||.
 Frog   479 -------------------VPCNISI------------QTAGIPQ-----------QTAAQPHTY 501

  Fly   745 V-VSAAGAGSSSLGAHSCSNLLVTQQMQQATSD---PMLNSTLAQL--------------LTSNS 791
            : :|..||                  .|:|||.   |::.|....|              :.|.:
 Frog   502 IAISKPGA------------------KQKATSQKIVPVIQSETVSLVFAPAPFPGQAQAVIMSPA 548

  Fly   792 RLQTAVANSSSSNSPSV----SAIATTNSNSNAPPVHYANVTSP--------LSVP-VPTHQHSP 843
            .|:.....:.....|:|    :|||.|.:   .|..|.:.:..|        :|.| ||....||
 Frog   549 PLKADTVLAPRITQPNVVIAPAAIAATPA---VPEFHGSILVGPAQQTQGSQISQPMVPRIFPSP 610

  Fly   844 K-----KSASLPMAVNSALHSPPLGSKIHGIGLATANVGSNSLSLSPESTFHESQDSPLSPTTSL 903
            .     |....|....|...||......|.....:.....:||| .|:|:...|.||.:   .::
 Frog   611 SSECLVKREKTPSQSCSTAPSPSSCRDYHNSRQGSPCASEHSLS-PPQSSGKASSDSQI---VTI 671

  Fly   904 KFQPRDTQRRAGHIHAEQKRRYNIKNGFDTLHALIPQLQLNPNAK-LSKAAMLQKGADHIKQLRQ 967
            |.|      |..||.||||||:|||..|.||:.::     :.|.| :|.|..|||..|:|.:|:|
 Frog   672 KNQ------RLKHISAEQKRRFNIKTAFSTLNNIV-----SSNTKPISHAITLQKTVDYIAKLQQ 725

  Fly   968 ERNVLKDKIEALRMERDELNNSLTHLHSILPANGAPVTRQGTEHVRQLYDIYVRYNTMNDWKFWI 1032
            ||..:.::...||.|.:|||.:::....:|||.|.|:|.|.:.|:|..:|.||:..|:.:|||||
 Frog   726 ERAQILEETRRLREEVEELNLAISSCQQLLPATGVPITPQSSLHMRDFFDKYVKSRTLQNWKFWI 790

  Fly  1033 LGLILEPLLASYTSTVSSASLDELRRTAFLWVDQHCSLIDLRPAVTNKLKYLSMHTDIVSEPPST 1097
            ..:|::||..|:...||:|||:|:..:...|:|.||||..|||.|.:.|:.||..|.|::: |..
 Frog   791 FSIIIKPLFESFNDMVSTASLEEMCSSTKEWLDMHCSLRALRPMVLHTLRQLSTTTSILTD-PMR 854

  Fly  1098 LQEEVAKALQNSS 1110
            |.|:..:|:...|
 Frog   855 LPEQAKQAVSKDS 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mondo	NP_001163032.1	HLH	909..969	CDD:238036	26/60 (43%)
mlxip	NP_001090682.1	HLH	672..728	CDD:238036	29/66 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5515
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2338
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D263805at33208
OrthoFinder	1	1.000	-	-		FOG0003465
OrthoInspector	1	1.000	-	-		otm48285
Panther	1	1.100	-	-	O	PTHR15741
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5458
SonicParanoid	1	1.000	-	-		X2831
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190