DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8671 and FAM102A

DIOPT Version :9

Sequence 1:	NP_001286124.1	Gene:	CG8671 / 35400	FlyBaseID:	FBgn0032938	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_001030331.1	Gene:	FAM102A / 399665	HGNCID:	31419	Length:	384	Species:	Homo sapiens

Alignment Length:	378	Identity:	142/378 - (37%)
Similarity:	180/378 - (47%)	Gaps:	111/378 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MAFMMKKKKYKFNVEVQLQDLVEVALVNEVLFAKIRLLDGGSFQEYSSREEVRNHRVEWNRSFEF 75
            |||:|||||:||.....|::|..|..||.|||.|:||||||.|...||||||:.:.|.|.:.|.|
Human     1 MAFLMKKKKFKFQTTFTLEELTAVPFVNGVLFCKVRLLDGGDFVSLSSREEVQENCVRWRKRFTF 65

  Fly    76 PCKMSANASTGVLDPCHLRISIRKEMKGGRSYYKLGFIDLNLAEFAGAGLTSRRFLLEGYDSRH- 139
            .||||||.:||:||||..|:|:|||:|||::|.||||.|||||||||:|.|.|..||||||:::
Human    66 VCKMSANPATGLLDPCVFRVSVRKELKGGKAYSKLGFADLNLAEFAGSGSTVRCCLLEGYDTKNT 130

  Fly   140 RLDNSMLRVSIKMHMLSGDILFKAPTPNLKSKQSKPSIDDFSNAATGVGLQIPTATALPSIGGGS 204
            |.|||:|:|:|.|.:||||..||.|....||                  :.||         |..
Human   131 RQDNSILKVTIGMFLLSGDPCFKTPPSTAKS------------------ISIP---------GQD 168

  Fly   205 GGASVSLGGSGVTLGGIPGNQSLPGTRPVSTTKEEDIDNQALIAAIVTDSGLSESSESGVTLTTD 269
            ....::..|.|.:.||...| ||.|:||...            ...:..|||.|..:..::
Human   169 SSLQLTCKGGGTSSGGSSTN-SLTGSRPPKA------------RPTILSSGLPEEPDQNLS---- 216

  Fly   270 NLQQHGSVVVANPISPVTQALPQLGIIGSNNYGTTGGAIGFTGAGNATLIEMGHSRNSSNTSQMS 334
                          ||                              ..:...|||||||..||.|
Human   217 --------------SP------------------------------EEVFHSGHSRNSSYASQQS 237

  Fly   335 KGSGYSSFSHSQHSRQSSEGDSGHASRQN----------------GQKGDEHQ 371
            |.||||    ::|||.||..|..|  |:|                |.:|.|.:
Human   238 KISGYS----TEHSRSSSLSDLTH--RRNTSTSSSASGGLGMTVEGPEGSERE 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8671	NP_001286124.1	NT-C2	22..161	CDD:287345	82/139 (59%)
FAM102A	NP_001030331.1	NT-C2	12..152	CDD:402120	82/139 (59%)
FAM102A	NP_001030331.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..315		43/179 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145143
Domainoid	1	1.000	179	1.000	Domainoid score	I3541
eggNOG	1	0.900	-	-		E1_28JCR
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2976
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318637at33208
OrthoFinder	1	1.000	-	-		FOG0002357
OrthoInspector	1	1.000	-	-		otm42150
orthoMCL	1	0.900	-	-		OOG6_106774
Panther	1	1.100	-	-	LDO	PTHR21456
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3220
SonicParanoid	1	1.000	-	-		X1553
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790