DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr39 and nr5a5

DIOPT Version :9

Sequence 1:	NP_476932.1	Gene:	Hr39 / 35398	FlyBaseID:	FBgn0261239	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_999944.2	Gene:	nr5a5 / 407626	ZFINID:	ZDB-GENE-030131-4652	Length:	537	Species:	Danio rerio

Alignment Length:	547	Identity:	159/547 - (29%)
Similarity:	243/547 - (44%)	Gaps:	101/547 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 ASSTVPSSGQEAQNLSMDSASSNLDTVGLGSSHPASPAGISRQQLINSPCPICGDKISGFHYGIF 391
            ||...||:.||   |..|..||.....|                     ||:|||::||:|||:.
Zfish    26 ASQERPSTSQE---LKPDPESSATQEEG---------------------CPVCGDRVSGYHYGLL 66

  Fly   392 SCESCKGFFKRTVQNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKGMKLEAIREDRTRGGRS 456
            :||||||||||:|||.|.|.|.....|.:.::.||:||.|||:||:..|||.||:|.||.||||:
Zfish    67 TCESCKGFFKRSVQNNKRYTCAEAQNCPMDLAQRKRCPYCRFQKCVAVGMKKEAVRADRMRGGRN 131

  Fly   457 TYQCSY-----------TLPNSMLSP----LLSPDQAAAAA----------AAAAVASQQQPHQR 496
            .:...|           |...:.::|    :..|.|...|.          .|:.......|.|.
Zfish   132 KFGPLYRRDRQLKQQRGTYHQANIAPYRVKIEGPQQLVPALPHDFHVINPNPASLGTDHYHPTQH 196

  Fly   497 LHQLNGFGGVPIPCSTSLPASPSLAGTSVKSEEMAETGKQSLRTGSVPPLLQEIMDVEHLWQYTD 561
            .|........|:....::|...:.:..|:....:...|     ....||..:||.     :.|..
Zfish   197 FHPNMSQSEFPVLLDCTMPRDRTFSDPSLPIHTVCYPG-----IHGYPPDKREIP-----FNYNP 251

  Fly   562 AEL--------------ARINQPLSAFASGSSSSSSSSGTSSGA---------------HAQLTN 597
            |.:              |....|.|..:|..:.|.|.:.||:.|               ..||..
Zfish   252 ASVTPPGPMSPTVLSTPAPTLTPASTPSSTPTPSQSLTPTSTTAPSSFFLNQLLQAEPDEKQLCM 316

  Fly   598 PLLAS--AGLSSNGENANPDLIAHLCNVADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCEL 660
            .:|||  ...:..|::...:..:.:|.:||..|:.:|:|.::..|||.:.:|||:.||.:.|.||
Zfish   317 RVLASLQREQACRGKHDRLNTFSIMCKMADQTLFGLVEWARNCELFKELKVDDQMVLLQSCWSEL 381

  Fly   661 LLFSCCFRSI--DTPGEIKMSQGRKI----TLSQAKSNGLQTCIERMLNLTDHLRRLRVDRYEYV 719
            |:.....|.:  ...|.|.:..|::|    .||||... |.:.:.|..:|...||.|::||.|:|
Zfish   382 LVLDHLCRQVAYGRDGSICLITGQQIEASTILSQAGMT-LSSLVSRAQDLVTKLRSLQLDREEFV 445

  Fly   720 AMKVIVLLQSDTTELQEAVKVRECQEKALQSLQAYTLAHYPDTPSKFGELLLRIPDLQRTCQLGK 784
            .:|.:||...|...:|...:|.:.||:..::|..:|:..:|....|||:||||:|:: |:..|..
Zfish   446 CLKYLVLFNPDVKSVQNRRQVEQTQERVNKALMDHTMQTHPGHSDKFGQLLLRLPEV-RSISLQV 509

  Fly   785 EMLTIKTRDGADF---NLLMELLRGEH 808
            |....:.....|.   :||.|:|..:|
Zfish   510 EEYLYQRHLLGDLPCNSLLTEMLHAKH 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr39	NP_476932.1	NR_DBD_Lrh-1_like	376..468	CDD:143541	50/102 (49%)
Hr39	NP_476932.1	NR_LBD_F2	617..779	CDD:132728	56/167 (34%)
nr5a5	NP_999944.2	NR_DBD_Lrh-1_like	51..143	CDD:143541	49/91 (54%)
nr5a5	NP_999944.2	NR_LBD_Ftz-F1_like	298..535	CDD:132742	70/238 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24680
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950