DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr39 and Hr4

DIOPT Version :9

Sequence 1:	NP_476932.1	Gene:	Hr39 / 35398	FlyBaseID:	FBgn0261239	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_001259161.1	Gene:	Hr4 / 31162	FlyBaseID:	FBgn0264562	Length:	2123	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	224/992 - (22%)
Similarity:	326/992 - (32%)	Gaps:	366/992 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LGSSAGGATGSR------------HNVSVTNIKCELDELPSPNGNMVPVIANYVH--GSLRIPLS 90
            |..|||||..:.            .|..:..:|.|:  :..|.||:.||.....:  ||::.| |
  Fly   626 LMQSAGGAAAAAAAAVAAQRMVCFSNARINGVKPEV--IGGPLGNLRPVGVGGGNGSGSVQCP-S 687

  Fly    91 GHSNHRESDSEEELASIENLKVRRRTA---ADKNGPRPMSWEGELSDTEVNGGEELMEMEPTIKS 152
            .|.:...|.|:....:......|....   .:..|.|.|.|..|
  Fly   688 PHPSSSSSSSQLSPQTPSQTPPRGTPTVIMGESCGVRTMVWGYE--------------------- 731

  Fly   153 EVVPAVAPPQPVCAL---------------QPIKTELENIAGEMQIQEKCYPQS-NTQHHAATKL 201
                   ||.|....               ||.:.:.:......|.|::...|| ..|.|..:
  Fly   732 -------PPPPSAGQSHGQHPQQQQQSPHHQPQQQQQQQQQQSQQQQQQQQQQSLGQQQHCLS-- 787

  Fly   202 KVAPTQSDPINLKFEPPLGDNSPLLAARSKSSSGGHLPLPTNPSPDSAIHSVYTHSSPSQSPLTS 266
                          .|..|..:|..::...|.|||.:..|..||              |.:|
  Fly   788 --------------SPSAGSLTPSSSSGGGSVSGGGVGGPLTPS--------------SVAP--- 821

  Fly   267 RHAPYTPSLSRNNSDASH---SSCYSYSSEFSPTHSPIQARHAPPAGTLYGNHHGIYRQMKVEAS 328
                      :||.:|:.   |...:...:......|.:..||.....|:.   |.|.|:
  Fly   822 ----------QNNEEAAQLLLSLGQTRIQDMRSRPHPFRTPHALNMERLWA---GDYSQL----- 868

  Fly   329 STVPSSGQEAQNLSMDS---ASSNLDTVGLGS----------SHPASPAGISRQQLINSPCPICG 380
               |....:|.|||...   .|||  :.|||.          ..|..|.....|.|:   |.||.
  Fly   869 ---PPGQLQALNLSAQQQQWGSSN--STGLGGVGGGMGGRNLEAPHEPTDEDEQPLV---CMICE 925

  Fly   381 DKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKGMKLEA 445
            ||.:|.||||.:||.||||||||||||:.|.||..|.|:::.:.|.:|..|||:||:::||.|:|
  Fly   926 DKATGLHYGIITCEGCKGFFKRTVQNRRVYTCVADGTCEITKAQRNRCQYCRFKKCIEQGMVLQA 990

  Fly   446 IREDRTRGGRST------YQCSY------------------------------------------ 462
            :||||..|||::      |:..|
  Fly   991 VREDRMPGGRNSGAVYNLYKVKYKKHKKTNQKQQQQAAQQQQQQAAAQQQHQQQQQHQQHQQHQQ 1055

  Fly   463 ---------------------TLPNSMLSP--LLSPDQAAAAAAAAAVA----SQQQPHQRLHQL 500
                                 ...:..|||  ||||.|...|||.||.|    .|||..|:..|.
  Fly  1056 QQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHLLSPQQQQLAAAVAAAAQHQQQQQQQQQQQQQA 1120

  Fly   501 NGFGGVPIPCSTSLPASPSLAGTSVKSEEMAETGKQSLRTGSVPPLLQEIMDVEHLWQYTDAELA 565
            ...|||       :...|...|.::|.|.:           ..||:.......:...|....:.|
  Fly  1121 KLMGGV-------VDMKPMFLGPALKPELL-----------QAPPMHSPAQQQQQQQQQQQQQQA 1167

  Fly   566 RINQPLSAFASGSSSSSSSSGTSSGAHAQ---------------------------LTNP----- 598
               .|..:.:|.........|.....|.|                           ||||
  Fly  1168 ---SPHLSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGGAQLPPHLVNGTILKTALTNPSEIVH 1229

  Fly   599 ---LLASAGLSSNGE-----------------NANPDL--IAH--------------LCNVADHR 627
               .|.||..||...                 :|..|:  :.|              |||:.|..
  Fly  1230 LRHRLDSAVSSSKDRQISYEHALGMIQTLIDCDAMEDIATLPHFSEFLEDKSEISEKLCNIGDSI 1294

  Fly   628 LYKIVKWCKSLPLFKNISIDDQICLLINSWCE-LLLFSCCFRSI-------------DTPGEIKM 678
            ::|:|.|.|.||.:..|.::....||.:.|.| |:|.:..::::             .:|....:
  Fly  1295 VHKLVSWTKKLPFYLEIPVEIHTKLLTDKWHEILILTTAAYQALHGKRRGEGGGSRHGSPASTPL 1359

  Fly   679 SQGRKITLS---------------------QAKSNGLQTC---------------------IERM 701
            |......||                     .:..:.||||                     :::|
  Fly  1360 STPTGTPLSTPIPSPAQPLHKDDPEFVSEVNSHLSTLQTCLTTLMGQPIAMEQLKLDVGHMVDKM 1424

  Fly   702 LNLTDHLRRLRVDRYEYVAMKVIVLLQSDTTELQEAVKVRECQEKALQSLQAYTLAHYPDTP-SK 765
            ..:|...||:::...|||.:||.:||.....||:      ..||:.:|.|::|.....|..| ::
  Fly  1425 TQITIMFRRIKLKMEEYVCLKVYILLNKAEVELE------SIQERYVQVLRSYLQNSSPQNPQAR 1483

  Fly   766 FGELLLRIPDLQRTCQL 782
            ..|||..||::|....|
  Fly  1484 LSELLSHIPEIQAAASL 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr39	NP_476932.1	NR_DBD_Lrh-1_like	376..468	CDD:143541	49/160 (31%)
Hr39	NP_476932.1	NR_LBD_F2	617..779	CDD:132728	52/232 (22%)
Hr4	NP_001259161.1	NR_DBD_DHR4_like	913..1002	CDD:143542	49/91 (54%)
Hr4	NP_001259161.1	NR_LBD_DHR4_like	1256..1515	CDD:132751	55/251 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5991
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.870