DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr39 and nr5a2

DIOPT Version :9

Sequence 1:	NP_476932.1	Gene:	Hr39 / 35398	FlyBaseID:	FBgn0261239	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_001300658.1	Gene:	nr5a2 / 30749	ZFINID:	ZDB-GENE-990415-79	Length:	517	Species:	Danio rerio

Alignment Length:	544	Identity:	157/544 - (28%)
Similarity:	234/544 - (43%)	Gaps:	127/544 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 VGLGSSHPAS---PAGISRQQL----------INSPCPICGDKISGFHYGIFSCESCKGFFKRTV 404
            :||..||...   |..:...|.          ::..||:||||:||:|||:.:||||||||||||
Zfish    10 LGLARSHGEQGHMPGNMQAPQFKMMDYSYDEDLDEMCPVCGDKVSGYHYGLLTCESCKGFFKRTV 74

  Fly   405 QNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPNSML 469
            ||.|.|.|:....||:..:.||:||.|||:|||..||||||:|.||.||||:.:
Zfish    75 QNNKRYTCIENQSCQIDKTQRKRCPYCRFQKCLTVGMKLEAVRADRMRGGRNKF----------- 128

  Fly   470 SPLLSPDQAAAAAAAAAV--------------------------------ASQQQP--------H 494
            .|:...|:|......|.:                                ||:..|        |
Zfish   129 GPMYKRDRALKQQKKALIRANGLKLEAMTQVMQTVPADLTITSAIQNIHSASKGLPLSHHHHHHH 193

  Fly   495 QRLHQLNGFGGVP-----------IPCSTSLPA-SPSLAGTSVKSEEMAETGKQSLRTGSVPPLL 547
            ...|..:...|:|           .|.|.::|. :..|.|........:.|.|.
Zfish   194 HHHHHSSSSAGLPPADFDRSPFVTSPVSMAMPPHAGGLQGYQAYGHFQSRTIKS----------- 247

  Fly   548 QEIMDVEHLWQYTDAELARINQP-LSAFASGSSSSSSSSGTSSGAH------------AQLTNPL 599
                  |:...||.:..:.:..| :.|:|.||..|.        .|            .|:...:
Zfish   248 ------EYPDPYTSSPESLMGYPYVEAYAGGSPPSF--------PHLVVELLKCEPDEPQVQAKI 298

  Fly   600 LA--SAGLSSNGENANPDLIAHLCNVADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLL 662
            ||  ....:|.|::...:....:|.:||..|:.||:|.:|...|:.:.:|||:.||.|.|.|||:
Zfish   299 LAYLQQEQASRGKHEKLNTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLI 363

  Fly   663 FSCCFRSI--DTPGEIKMSQGRKI----TLSQAKSNGLQTCIERMLNLTDHLRRLRVDRYEYVAM 721
            ....||.:  ...|.|.:..|:::    ..|||.:. |...:.....|...||.|::|:.|:|.:
Zfish   364 LDHVFRQVMHAKEGSILLVTGQQVDYALIASQAGAT-LNNLLSHAQELVSKLRSLQLDQREFVCL 427

  Fly   722 KVIVLLQSDTTELQEAVKVRECQEKALQSLQAYTLAHYPDTPSKFGELLLRIPDLQRTCQLGKEM 786
            |.:||...|...|:....|...||:...:|..|.:.:||....|||:||||:|:::......:|.
Zfish   428 KFLVLFSLDVKNLENFHLVESVQEQVNAALLDYVMCNYPQQTDKFGQLLLRLPEIRAISLQAEEY 492

  Fly   787 LTIKTRDGADF---NLLMELLRGE 807
            |..|..:| |.   |||:|:|..:
Zfish   493 LYYKHLNG-DVPCNNLLIEMLHAK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr39	NP_476932.1	NR_DBD_Lrh-1_like	376..468	CDD:143541	53/91 (58%)
Hr39	NP_476932.1	NR_LBD_F2	617..779	CDD:132728	55/167 (33%)
nr5a2	NP_001300658.1	NR_DBD_Lrh-1_like	46..138	CDD:143541	55/102 (54%)
		STAT6_C	204..>294	CDD:291272	19/114 (17%)
		NR_LBD_Lrh-1	277..517	CDD:132754	71/249 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592410
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24680
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950