DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr39 and NR3C1

DIOPT Version :9

Sequence 1:	NP_476932.1	Gene:	Hr39 / 35398	FlyBaseID:	FBgn0261239	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_001019265.1	Gene:	NR3C1 / 2908	HGNCID:	7978	Length:	778	Species:	Homo sapiens

Alignment Length:	828	Identity:	174/828 - (21%)
Similarity:	284/828 - (34%)	Gaps:	230/828 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PLGGSSGYQVP-------VNMCTTTVANTTTTLGSSAGGATGSRHNVSVTNIKCELDELPSPNGN 72
            |.|..|..|.|       ::|........|..:|:..|.....:.::|......:|.|....|.|
Human    66 PKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLN 130

  Fly    73 MVPVIANYVHGSLRIPLSGHSNHRESDSEEELASIENLKVRRRTAADKNGPRPMSWEGE------ 131
            ....:......|....:|.....:|........|.|...::.:|..  ||.....:..:
Human   131 RSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGT--NGGNVKLYTTDQSTFDI 193

  Fly   132 LSDTEVNGGEELMEM-EPTIKSEVVPAVAPPQPVCALQPIKTELENIAGEMQIQEKCYPQSNTQH 195
            |.|.|.:.|....|. |...:|:::     ....|.|.|:..|.::...|....|.|.|
Human   194 LQDLEFSSGSPGKETNESPWRSDLL-----IDENCLLSPLAGEDDSFLLEGNSNEDCKP------ 247

  Fly   196 HAATKLKVAPTQSDPINLKFEPPLGDNSPLLAARSKSSSGGHLPLPTNPSPD------------S 248
                  .:.|..        :|.:.||..|:.:   |.|...||.......|            .
Human   248 ------LILPDT--------KPKIKDNGDLVLS---SPSNVTLPQVKTEKEDFIELCTPGVIKQE 295

  Fly   249 AIHSVYTHSS-PSQSPLTSRHAPYTPSLSRNNSDASHSSCYSYSSEFSPTHSPIQARHAPPAGTL 312
            .:.:||..:| |..:.:.::.:    ::|.:....|....|.|...   |.|..|.:...|
Human   296 KLGTVYCQASFPGANIIGNKMS----AISVHGVSTSGGQMYHYDMN---TASLSQQQDQKP---- 349

  Fly   313 YGNHHGIYRQMKVEASSTVP--SSGQEAQNLSMDSASSNLDTVGL-----------GSSHP---- 360
                  |:        :.:|  ..|.|..|....|...||.::|.           |.|.|
Human   350 ------IF--------NVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRP 400

  Fly   361 --ASPAGISRQQLINSP---CPICGDKISGFHYGIFSCESCKGFFKRTVQNRK-NYVCVRGGPCQ 419
              :||...|.......|   |.:|.|:.||.|||:.:|.|||.||||.|:.|: ||:|.....|.
Human   401 DVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCI 465

  Fly   420 VSISTRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPNSMLSPLLSPDQAAAAAAA 484
            :....||.|||||:.||||.||.|||         |.|.:
Human   466 IDKIRRKNCPACRYRKCLQAGMNLEA---------RKTKK------------------------- 496

  Fly   485 AAVASQQQPHQRLHQLNGFGGVPIPCSTSLPASPSLAGTSVKSEEMAETGKQSLRTGSVPPLLQE 549
             .:...||                            |.|.|..|.....|.:::...::|.|...
Human   497 -KIKGIQQ----------------------------ATTGVSQETSENPGNKTIVPATLPQLTPT 532

  Fly   550 IMDVEHLWQYTDAELARINQPLSAFASGSSSSSSSSGTSSGAHAQLTNPLLASAGLSSNGENANP 614
            ::.:                                       .::..|.:..||..|:..::..
Human   533 LVSL---------------------------------------LEVIEPEVLYAGYDSSVPDSTW 558

  Fly   615 DLIAHLCNVADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCFRSIDTPGEIKMS 679
            .::..|..:...::...|||.|::|.|:|:.:|||:.||..||..|:.|:..:||........:.
Human   559 RIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLC 623

  Fly   680 QGRKITLSQAKSNGLQTCI----ERMLNLTDHLRRLRVDRYEYVAMKVIVLLQS------DTTEL 734
            ....:.:::.:..  ..|:    :.||.::..|.||:|...||:.||.::||.|      .:.||
Human   624 FAPDLIINEQRMT--LPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQEL 686

  Fly   735 QEAVKVRECQE--KAL--------QSLQA-YTLAHYPDTPSKFGELLL 771
            .:.:::...:|  ||:        |:.|. |.|....|:..:..|.||
Human   687 FDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLL 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr39	NP_476932.1	NR_DBD_Lrh-1_like	376..468	CDD:143541	40/92 (43%)
Hr39	NP_476932.1	NR_LBD_F2	617..779	CDD:132728	46/176 (26%)
NR3C1	NP_001019265.1	Modulating	1..420		75/408 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		GCR	26..401	CDD:280340	71/389 (18%)
		Required for high transcriptional activity of isoform Alpha-C3. /evidence=ECO:0000269\|PubMed:23820903	98..115		3/16 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..183		9/54 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..415		5/20 (25%)
		NR_DBD_GR_PR	417..495	CDD:143546	40/86 (47%)
		Interaction with CLOCK	486..778		66/353 (19%)
		Hinge	488..524		12/98 (12%)
		NR_LBD_GR	532..778	CDD:132761	50/244 (20%)
		Interaction with CRY1. /evidence=ECO:0000269\|PubMed:22170608	533..698		39/205 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910