DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr39 and NR6A1

DIOPT Version :9

Sequence 1:	NP_476932.1	Gene:	Hr39 / 35398	FlyBaseID:	FBgn0261239	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_201591.2	Gene:	NR6A1 / 2649	HGNCID:	7985	Length:	480	Species:	Homo sapiens

Alignment Length:	416	Identity:	129/416 - (31%)
Similarity:	189/416 - (45%)	Gaps:	41/416 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 CPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKG 440
            |.||||:.:|.||||.|||.|||||||::.|::.|.|.|...|.:|...|.:|..||..||||.|
Human    60 CLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMG 124

  Fly   441 MKLEAIREDRTRGGRSTYQCSYTLPNSMLSPLLSPDQAAAAAAAAAVASQQQPHQRLHQLNGFGG 505
            |..:|||||...|||          |..:.|:...::......:.....::..|...|..:....
Human   125 MNRKAIREDGMPGGR----------NKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSS 179

  Fly   506 VPIPCSTSLPASPSLAGTSVKSEEMAETGKQSLRTG----SVPPLLQEIMDVEHLWQYTDAELAR 566
            .....|.|...||....:|.:|.|:  .|..:.|..    ||||..|.|   .||:.|:.
Human   180 PGNRASESNQPSPGSTLSSSRSVEL--NGFMAFREQYMGMSVPPHYQYI---PHLFSYSG----- 234

  Fly   567 INQPLSAFASGSSSSSSSSGTSSGAHAQ----LTNPLLASAGLSSNGENANPDLIAHLCNVADHR 627
             :.||....:.|....|.|.......|:    |..|:|...|.:.    ...:|.|.||.:||..
Human   235 -HSPLLPQQARSLDPQSYSLIHQLLSAEDLEPLGTPMLIEDGYAV----TQAELFALLCRLADEL 294

  Fly   628 LYKIVKWCKSLPLFKNISIDDQICLLINSWCEL-LLFSCCFRSIDTPGEI-----KMSQGRKITL 686
            |::.:.|.|.||.|..:||.|..|||.::|.|| ||.|....|....||:     |.|...: .|
Human   295 LFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDE-EL 358

  Fly   687 SQAKSNGLQTCIERMLNLTDHLRRLRVDRYEYVAMKVIVLLQSDTTELQEAVKVRECQEKALQSL 751
            .:....|::. |||::.|.....:|:|...||..||.|..|..|...|..|.::.:..::.....
Human   359 HRFSDEGMEV-IERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYIC 422

  Fly   752 QAYTLAHYPDTPSKFGELLLRIPDLQ 777
            |.:|...|...|::|.:|::.:|:::
Human   423 QDFTEYKYTHQPNRFPDLMMCLPEIR 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr39	NP_476932.1	NR_DBD_Lrh-1_like	376..468	CDD:143541	45/91 (49%)
Hr39	NP_476932.1	NR_LBD_F2	617..779	CDD:132728	52/167 (31%)
NR6A1	NP_201591.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		NR_DBD_GCNF_like	52..141	CDD:143543	44/90 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..150		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..199		6/36 (17%)
		Sufficient for interaction with UIMC1. /evidence=ECO:0000250	172..253		23/91 (25%)
		NR_LBD_DHR4_like	256..467	CDD:132751	58/199 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5991
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto90780
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.870