Protein Alignment Hr39 and Nr5a2

DIOPT Version :9

• Sequence 1: NP_476932.1
• Gene: Hr39 / 35398
• FlyBaseID: FBgn0261239
• Length: 808
• Species: Drosophila melanogaster
• Sequence 2: NP_109601.1
• Gene: Nr5a2 / 26424
• MGIID: 1346834
• Length: 560
• Species: Mus musculus
• Alignment Length: 568
• Identity: 162/568 - (28%)
• Similarity: 245/568 - (43%)
• Gaps: 156/568 - (27%)

  Fly   322 QMKVEASSTVPSSGQEAQNLSMDSASSNLDTVGLGSSHPASPAGISRQQLIN--------SPCPI 378
            :::.||...|.|.|::.|      ...|:.              :|:.:::|        ..||:
Mouse    65 KVETEAPGLVRSHGEQGQ------MPENMQ--------------VSQFKMVNYSYDEDLEELCPV 109

  Fly   379 CGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKGMKL 443
            ||||:||:|||:.:||||||||||||||:|.|.|:....||:..:.||:||.|||:||:..||||
Mouse   110 CGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCPYCRFKKCIDVGMKL 174

  Fly   444 EAIREDRTRGGRSTY-----------------------------QCSYTLPNSMLS--------- 470
            ||:|.||.||||:.:                             |....:|:.:.|
Mouse   175 EAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTSAIQNIHSAS 239

  Fly   471 ---PL----LSP-DQAAAAAAAAAVASQQQPHQRLHQLNGFGGVPI---------PCSTSLPASP 518
               ||    |.| |...:....:.::....||..||....:|..|.         |.|:|   ..
Mouse   240 KGLPLSHVALPPTDYDRSPFVTSPISMTMPPHSSLHGYQPYGHFPSRAIKSEYPDPYSSS---PE 301

  Fly   519 SLAGTSVKSEEMAETGKQSLRTGSVPPLLQEIMDVE--------HLWQYTDAELARIN--QPLSA 573
            |:.|.|...      |.|:....|:|.|:.|::..|        .:..|...|.:..|  :.|||
Mouse   302 SMMGYSYMD------GYQTNSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQSNRNRQEKLSA 360

  Fly   574 FASGSSSSSSSSGTSSGAHAQLTNPLLASAGLSSNGENANPDLIAHLCNVADHRLYKIVKWCKSL 638
            |                             ||              ||.:||..|:.||:|.:|.
Mouse   361 F-----------------------------GL--------------LCKMADQTLFSIVEWARSS 382

  Fly   639 PLFKNISIDDQICLLINSWCELLLFSCCFRSI--DTPGEIKMSQGRKITLSQAKSNGLQTCIERM 701
            ..|:.:.:|||:.||.|.|.|||:....:|.:  ...|.|.:..|..:..|...|: .:.....:
Mouse   383 IFFRELKVDDQMKLLQNCWSELLILDHIYRQVAHGKEGTIFLVTGEHVDYSTIISH-TEVAFNNL 446

  Fly   702 LNLTD----HLRRLRVDRYEYVAMKVIVLLQSDTTELQEAVKVRECQEKALQSLQAYTLAHYPDT 762
            |:|..    .||.|:.|:.|:|.:|.:||..||...|:....|...||:...:|..||:.:||..
Mouse   447 LSLAQELVVRLRSLQFDQREFVCLKFLVLFSSDVKNLENLQLVEGVQEQVNAALLDYTVCNYPQQ 511

  Fly   763 PSKFGELLLRIPDLQRTCQLGKEMLTIKTRDGADF---NLLMELLRGE 807
            ..|||:||||:|:::...:..::.|..|..:| |.   |||:|:|..:
Mouse   512 TEKFGQLLLRLPEIRAISKQAEDYLYYKHVNG-DVPYNNLLIEMLHAK 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr39	NP_476932.1	NR_DBD_Lrh-1_like	376..468	CDD:143541	54/120 (45%)
		NR_LBD_F2	617..779	CDD:132728	56/167 (34%)
Nr5a2	NP_109601.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	21..55
		NR_DBD_Lrh-1_like	107..199	CDD:143541	52/91 (57%)
		FTZ-F1 box	176..205		8/28 (29%)
		NR_LBD_Lrh-1	320..560	CDD:132754	78/284 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847180
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940