DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr39 and nhr-3

DIOPT Version :9

Sequence 1:	NP_476932.1	Gene:	Hr39 / 35398	FlyBaseID:	FBgn0261239	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_510423.1	Gene:	nhr-3 / 181551	WormBaseID:	WBGene00003602	Length:	463	Species:	Caenorhabditis elegans

Alignment Length:	498	Identity:	121/498 - (24%)
Similarity:	205/498 - (41%)	Gaps:	115/498 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 GQEAQNLSMDSASSNLDTVGLGSSHPASPAGISRQQLINSPCPICGDKISGFHYGIFSCESCKGF 399
            |...|..||:|    |....||...|:...||..::  ::.|.:|.|:.||.|||:.:|..||||
Worm    18 GSPGQTFSMES----LLKPELGEYSPSGENGIDGEE--STICSVCCDEASGRHYGVVACFGCKGF 76

  Fly   400 FKRTVQNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTL 464
            |:|||:..|||||.....|::..:.|..|.:|||:|||:.||:.:|||.||.:.||..
Worm    77 FRRTVRAGKNYVCRYSKKCRIDKAGRNVCRSCRFQKCLEVGMEPDAIRPDRDKTGRQK------- 134

  Fly   465 PNSMLSPLLSPDQAAAAAAAAAVASQQQPHQRLHQLNGFGGVPIPCSTSLPASPSLAGTSVKSEE 529
                 :|..:.:.:....:..::...                 :||..........|.||..|.
Worm   135 -----NPRRNTEGSIKKVSVGSILGD-----------------LPCLNKFKDDSDDAATSPSSR- 176

  Fly   530 MAETGKQSLRTGSV-PPLLQEIMDVEHLWQYTDAELARINQPLSAFASGSSSSSSSSGTSSGAHA 593
             |::....||...: ..:|..:.::|::          :.|....|.:...|.....       .
Worm   177 -ADSAPMDLRPSFIDESVLTTLTEIENI----------VIQLQDNFETNQQSLPPMG-------E 223

  Fly   594 QLTNPLLASAG--LSSNGENANPDLIAHLCNVADHRLYKIV----KWCKSLPLFKNISIDDQICL 652
            .:|.|.|.:|.  |:.||.....|     .|.....|.:::    .:..:|....::...:::.:
Worm   224 AITKPSLIAARTLLNFNGAKGVAD-----ANCVSSNLRRMIVFTFDYINTLRPIADLHPSEKLVI 283

  Fly   653 ---LINSWCELLLFSCCFRS--IDTP--GEIKMSQGRKITLSQA----------------KSNGL 694
               :|:.:|  :|| |.::|  |:.|  ..|.:..|.|:..||.                |::.:
Worm   284 ARSIISPFC--ILF-CGYQSVAIEAPEHDSIYLPSGHKLPASQLLFTKDSDQKKYILLENKADNV 345

  Fly   695 QTCIERMLNLTDHLRRLRVDRYEYVAMKVIVL-------LQSDTTELQEAVKVRECQEKALQSLQ 752
            :..:..|  :...||||.|.:.|.||:|.|:.       |.:::.||  .|..||..:.||.|
Worm   346 RRNMTEM--IIQQLRRLNVTKTEMVALKAIMALDHNVKGLSAESCEL--LVVARESVQNALFS-- 404

  Fly   753 AYTLAHY--PDTPSKFGELLLRIPDLQRTC-------QLGKEM 786
             :.:|.:  .:..|:|..|||.|....|..       ||.:::
Worm   405 -HLIATFGTAEATSRFAHLLLLIASATRVAYSLSSFFQLSRDV 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr39	NP_476932.1	NR_DBD_Lrh-1_like	376..468	CDD:143541	40/91 (44%)
Hr39	NP_476932.1	NR_LBD_F2	617..779	CDD:132728	44/197 (22%)
nhr-3	NP_510423.1	NR_DBD_HNF4A	53..128	CDD:143518	37/74 (50%)
nhr-3	NP_510423.1	NR_LBD	249..432	CDD:132726	44/192 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010