DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr39 and Nr6a1

DIOPT Version :9

Sequence 1:	NP_476932.1	Gene:	Hr39 / 35398	FlyBaseID:	FBgn0261239	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_034394.1	Gene:	Nr6a1 / 14536	MGIID:	1352459	Length:	495	Species:	Mus musculus

Alignment Length:	441	Identity:	134/441 - (30%)
Similarity:	198/441 - (44%)	Gaps:	43/441 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 DTVGLGSSHPASPAGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRG 415
            |::.||..|  .|..:...:.....|.||||:.:|.||||.|||.|||||||::.|::.|.|.|.
Mouse    52 DSLTLGQGH--IPVSVPDDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRD 114

  Fly   416 GPCQVSISTRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPNSMLSPLLSPDQAAA 480
            ..|.:|...|.:|..||..||||.||..:|||||...|||          |..:.|:...::...
Mouse   115 KNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGR----------NKSIGPVQISEEEIE 169

  Fly   481 AAAAAAVASQQQPHQRLHQLNGFGGVPIPCSTSLPASPSLAGTSVKSEEMAETGKQSLRTG---- 541
            ...:.....::..|...|..:.........|.|...||....:|.:|.|:  .|..:.|..
Mouse   170 RIMSGQEFEEEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSSRSVEL--NGFMAFRDQYMGM 232

  Fly   542 SVPPLLQEIMDVEHLWQYTDAELARINQPLSAFASGSSSSSSSSGTSSGAHAQ----LTNPLLAS 602
            ||||..|.|   .||:.|:.      :.||....:.|....|.|.......|:    |..|:|..
Mouse   233 SVPPHYQYI---PHLFSYSG------HSPLLPPQARSLDPQSYSLIHQLMSAEDLEPLGTPMLIE 288

  Fly   603 AGLSSNGENANPDLIAHLCNVADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCEL-LLFSCC 666
            .|.:.    ...:|.|.||.:||..|::.:.|.|.||.|..:||.|..|||.::|.|| ||.|..
Mouse   289 DGYAV----TQAELFALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLT 349

  Fly   667 FRSIDTPGEI-----KMSQGRKITLSQAKSNGLQTCIERMLNLTDHLRRLRVDRYEYVAMKVIVL 726
            ..|....||:     |.|...: .|.:....|::. |||::.|.....:|:|...||..||.|..
Mouse   350 VYSKQIFGELADVTAKYSPSDE-ELHRFSDEGMEV-IERLIYLYHKFHQLKVSNEEYACMKAINF 412

  Fly   727 LQSDTTELQEAVKVRECQEKALQSLQAYTLAHYPDTPSKFGELLLRIPDLQ 777
            |..|...|..|.::.:..::.....|.:|...|...|::|.:|::.:|:::
Mouse   413 LNQDIRGLTSASQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIR 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr39	NP_476932.1	NR_DBD_Lrh-1_like	376..468	CDD:143541	45/91 (49%)
Hr39	NP_476932.1	NR_LBD_F2	617..779	CDD:132728	52/167 (31%)
Nr6a1	NP_034394.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		NR_DBD_GCNF_like	67..156	CDD:143543	44/98 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..165		9/29 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..214		6/36 (17%)
		Sufficient for interaction with UIMC1	187..268		23/91 (25%)
		NR_LBD_DHR4_like	271..482	CDD:132751	58/199 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5991
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.870