DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr39 and nr4a2a

DIOPT Version :9

Sequence 1:	NP_476932.1	Gene:	Hr39 / 35398	FlyBaseID:	FBgn0261239	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_001106956.1	Gene:	nr4a2a / 100008101	ZFINID:	ZDB-GENE-990415-184	Length:	598	Species:	Danio rerio

Alignment Length:	700	Identity:	150/700 - (21%)
Similarity:	256/700 - (36%)	Gaps:	185/700 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 PRPMSWEGELSDTEVNGGEELMEMEPTIKSEVVPA--VAPPQPVCALQ-PIKTELENIAGEMQIQ 184
            |..:.:..:|::||:......:....|.......:  |.||   |..| |...|..:|..| .:|
Zfish    37 PEFVKFSMDLTNTEITAATTSLPSFSTFMDNYNTSYDVKPP---CLYQVPHSGEQSSIKVE-DVQ 97

  Fly   185 EKCYPQSNTQHHAATKLKVAPTQSDPINLKFEPPLGDNSPLLAARSKSSSGGHLPLPTN--PSPD 247
            ...|.|   |.|...:.:.......|:  .|:|    :||            |.|.|.|  ..|:
Zfish    98 MHTYHQ---QSHLGPQSEEMMAHPGPV--YFKP----SSP------------HGPGPANFQVQPN 141

  Fly   248 SAIHSVYTHSSPSQSPLTSRHAPYTPS--LSRNNSDASHSSCYSYSSEFSPTHSPIQARHAPPAG 310
                    |.......|.:.|..|..|  :.:..:..|..|.:|:..  ||..:|:.:......|
Zfish   142 --------HMWEDPGSLHTFHQNYMTSHMIDQRKNPVSRLSLFSFKQ--SPPGTPVSSCQMRFDG 196

  Fly   311 TLYGNHH---GIYRQMKVEASSTVPSSGQEAQNLSMDSASSNLDTVGLGSSH-----------PA 361
            .|:.:.|   |.:|.:..: |..|||:.::...::.        |..|..||           |.
Zfish   197 PLHVSMHDSTGAHRTLDSQ-SFAVPSTIRKQAGIAF--------THSLQLSHGHQLMDSQVPSPP 252

  Fly   362 SPAGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRGGPCQVSISTRK 426
            |....|.:.|    |.:|||..:..|||:.:||.||||||||||....|||:....|.|....|.
Zfish   253 SRGSPSTEGL----CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN 313

  Fly   427 KCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPNSMLSPL-LSPDQAAAAAAAAAVASQ 490
            :|..|||:|||..||..|.:|.|..:|.|.      .||:...||. .||.....:..:|.|.:.
Zfish   314 RCQYCRFQKCLVVGMVKEVVRTDNLKGRRG------RLPSKPKSPQESSPPSPPVSLISALVRAH 372

  Fly   491 QQPHQRLHQLNGFGGVPIPCSTSLPASP--SLAGTSVKSEEMAETGKQSLRTGSVPPLLQEIMDV 553
            ...:..::.|:         .|...|:|  .|:|.                            |.
Zfish   373 VDSNPSMNSLD---------YTRFQANPDYQLSGD----------------------------DT 400

  Fly   554 EHLWQYTDAELARINQPLSAFASGSSSSSSSSGTSSGAHAQLTNPLLASAGLSSNGENANPDLIA 618
            :|:.|:.|            ..:||
Zfish   401 QHIQQFYD------------LLTGS---------------------------------------- 413

  Fly   619 HLCNVADHRLYKIVK-WCKSLPLFKNISIDDQICLLINSWCELLLFSCCFRSIDTPGEIKMSQGR 682
                      .:|:: |.:.:|.|.::...||..|..:::.||.:....:||  .|.|.|:....
Zfish   414 ----------MEIIRGWAEKIPGFTDLPKPDQDLLFESAFLELFVLRLAYRS--NPMESKLIFCN 466

  Fly   683 KITLSQAKS-NGLQTCIERMLNLTDHLRRLRVDRYEYVAMKVIVLLQSDTTELQEAVKVRECQEK 746
            .:.|.:.:. .|....|:.::..:.:|:.:.:|...:..:..:.:: ::...|:|..:|.:.|.|
Zfish   467 GVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNLDISAFSCIAALAMV-TERHGLKEPKRVEDLQNK 530

  Fly   747 ALQSLQAYTLAHYP--DTPSKFGELLLRIPDLQRTCQLG-KEMLTIKTRD 793
            .:..|:.....:..  :.|:...:||.::|:|:..|..| :.:..:|..|
Zfish   531 IVNCLKDQVTFNGGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLED 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr39	NP_476932.1	NR_DBD_Lrh-1_like	376..468	CDD:143541	41/91 (45%)
Hr39	NP_476932.1	NR_LBD_F2	617..779	CDD:132728	30/165 (18%)
nr4a2a	NP_001106956.1	NR_DBD_NGFI-B	261..335	CDD:143527	36/77 (47%)
nr4a2a	NP_001106956.1	NR_LBD_Nurr1	367..598	CDD:132756	47/315 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910