DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8677 and RSF1

DIOPT Version :9

Sequence 1:NP_001286123.1 Gene:CG8677 / 35397 FlyBaseID:FBgn0026577 Length:2663 Species:Drosophila melanogaster
Sequence 2:NP_057662.3 Gene:RSF1 / 51773 HGNCID:18118 Length:1441 Species:Homo sapiens


Alignment Length:2115 Identity:477/2115 - (22%)
Similarity:755/2115 - (35%) Gaps:792/2115 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 ASSAAAAAPTNPIPLPTDSISEECKDDDALTSTLHTCANDPDFAVICAFLQKFGKDLGL-NLPNF 66
            |::|||||...|...|                  .:|   |:|||:|:||:::|..|.| .|| |
Human     2 ATAAAAAAVMAPPGCP------------------GSC---PNFAVVCSFLERYGPLLDLPELP-F 44

  Fly    67 KHLQEWL------TNNNDVP-ELRDLHIKLLRKTRKTVHEKSWESALSKFCFGYSVQDAWEIERF 124
            ..|:..|      ..|.:|| ||.:||:||:||..|:|....||..|.|.|..::...|||:|:.
Human    45 PELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKK 109

  Fly   125 GYRNSSLKVKLRIFRELLESQFERNAKFRAHILTLNADTLRSEPIGRDRLGHAYWLTQDAHCNLR 189
            ||...|::.||.:.:.|.|.||:.|.||:..|...:|||:|.:|||||:.|..||...|...|:|
Human   110 GYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVR 174

  Fly   190 IYQEHLDEE---IWQVVATNRDEFVNLISRLRG--NEVVLPSKDIGEADEDTSSSNSCHPKPPPP 249
            :|.|..|::   .|:.:..||:|....::.|:.  :.|:|.:    .:.:|.||..|     |..
Human   175 MYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKN----SSQQDNSSRES-----PSL 230

  Fly   250 EQKEEEDDEEVGDEPEKTVPNLKIKLRSPEQEDQKSKKVKPLLISQAKLSSSASPAPTKKRSIED 314
            |.:|.:.:||                 :|:||:||..:         |:.|...|...:.||..:
Human   231 EDEETKKEEE-----------------TPKQEEQKESE---------KMKSEEQPMDLENRSTAN 269

  Fly   315 VDSSPTASQEEQQKKHRPTLLDTKRIKKPSRYESTKDEIEEESGEEDEEEEDEEDSELDEGEEEE 379
            |....|..:|::.:|....|....:::||                            |.|.||::
Human   270 VLEETTVKKEKEDEKELVKLPVIVKLEKP----------------------------LPENEEKK 306

  Fly   380 DVDSAAADIEEDDDEEDTGEPIEDPTIVVQGQGSGLDCEAIPYNLIGNFDYEDDLEIGEAIADPM 444
            .:.      ||.|..::..:||:                               :|:.|..||| 
Human   307 IIK------EESDSFKENVKPIK-------------------------------VEVKECRADP- 333

  Fly   445 LHVIGQGWGTDCLVGNGKNEASVEETSTRTSEPKATFFFGEPGCLKLSPMKQTSKPEAKRGIFDS 509
                                                                             
Human   334 ----------------------------------------------------------------- 333

  Fly   510 LSEEKTNGESEKCIVNTPPRNGSELTKTLGDSEETASASAATLEETNICQEANVNKISDDQIKKK 574
               :.|....||.:...|.|  .|....:..|.|....|.   |||        .|:.:||..| 
Human   334 ---KDTKSSMEKPVAQEPER--IEFGGNIKSSHEITEKST---EET--------EKLKNDQQAK- 381

  Fly   575 ESVPVAKRNIQDSTISVIEKNEEISKGRTESEAIEEGVRNRTEVSVLQNNSNESDNSSIQTQDQH 639
              :|:.||.|                                                       
Human   382 --IPLKKREI------------------------------------------------------- 389

  Fly   640 KVPADLNNTKKPVTEKCVLESGTVEDKLVINHQQISTNALDTACDEKLSCETESPVPNQHDSKMK 704
                                                          |||.:.:|||..   ...|
Human   390 ----------------------------------------------KLSDDFDSPVKG---PLCK 405

  Fly   705 SEQETATSAKESVSESSPTDGEDETAK-----------SKCLIDPYAGKTNDKGIIINKIDKAEG 758
            |...|....|:.:.:      |:||.|           .|.|::   |:.:|:.:..|       
Human   406 SVTPTKEFLKDEIKQ------EEETCKRISTITALGHEGKQLVN---GEVSDERVAPN------- 454

  Fly   759 VIKTLLQDDPPKDISKSETNTTCLEINISPSAEHRISEKVQTIEPSTSQNLLFEDNG-------- 815
             .||     .|.:....||                   |.::..||..:|::.|.||        
Human   455 -FKT-----EPIETKFYET-------------------KEESYSPSKDRNIITEGNGTESLNSVI 494

  Fly   816 ---KSGEVDGKSRTSGAVEEISKTSTLLNRKRRLNDSQSALRNSTSESEVHEEEPQDDDPTLDDL 877
               |:||::            .:|:.|   ::..:.|.|.|...:.::::.|.:|.:.:.:||..
Human   495 TSMKTGELE------------KETAPL---RKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSS 544

  Fly   878 DVGGKRIKMRPKTTNAESRRKVEAQKTQIEETTSSS--GEDDARIRRKCIAPHTK--TKPTLEEI 938
            ::.                 |..:.||.:..|.|.:  ||:.        :|.||  .:|.:.|.
Human   545 EMA-----------------KDLSSKTALSSTESCTMKGEEK--------SPKTKKDKRPPILEC 584

  Fly   939 IERKLKKSIEMDLPEKTTEKVMEMPTQLMQKTREATPPIISLSPQKKTPITKPLKKNLLTQLRQE 1003
            :| ||:||                     :||      .:....|:.:||.:.:.|:.|      
Human   585 LE-KLEKS---------------------KKT------FLDKDAQRLSPIPEEVPKSTL------ 615

  Fly  1004 ESEEETIPRKRTNSETLVPAIPASNVLCQPDERHRKRRSSEDANEAFSKESSPTEVPPSAVSEKL 1068
            |||:...|.....|       |.||::     .|.::.:||       ||....:...:...:.:
Human   616 ESEKPGSPEAAETS-------PPSNII-----DHCEKLASE-------KEVVECQSTSTVGGQSV 661

  Fly  1069 KRNNEQDIQEEVEDPLAMSVKDSLRSAKDQSPVPEGSARRSGRRGGPAVIHSELPQPKRTRGGAR 1133
            |:.:.:.::|:.|  ......|:|.:|:.                      |.:.:|..|:|..:
Human   662 KKVDLETLKEDSE--FTKVEMDNLDNAQT----------------------SGIEEPSETKGSMQ 702

  Fly  1134 D-----KMQPE------VNAELKQESEDDE-KISTKIKSEAKDDPAPESPENRKKPEEKPIKEEP 1186
            .     |:.||      .|.|:..|.:.:. |::.:|.|..|   .|:||....:||.|..|.| 
Human   703 KSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKK---KPDSPPKVLEPENKQEKTE- 763

  Fly  1187 NEEPKPKVGR--GRGPRKKREVDTTNIIETNDSETPVRQSRRIAQQKIKEEAERRKQEEVAL-RT 1248
            .||.|..|||  .|.||..|  .|..:.|..|.:         |.:|..|..:..::|..|| :|
Human   764 KEEEKTNVGRTLRRSPRISR--PTAKVAEIRDQK---------ADKKRGEGEDEVEEESTALQKT 817

  Fly  1249 MKQELKKKKKAEKEADPTVLEPSGEESESEASEAEEEARNKKKKKCPGKDGWSSDSEEQPESEEE 1313
            .|:|:.||.:.:..:..:.::|.|:...:       .:|.:.:.|....|.......|:..:..|
Human   818 DKKEILKKSEKDTNSKVSKVKPKGKVRWT-------GSRTRGRWKYSSNDESEGSGSEKSSAASE 875

  Fly  1314 EEEPPHYETDPGSPLFRSDHEFSPESELEDESQVVPMKRARTVRKENADDLEEEDAEEACQKCGK 1378
            |||                       |.|.|..::            |||      :|.|:|||.
Human   876 EEE-----------------------EKESEEAIL------------ADD------DEPCKKCGL 899

  Fly  1379 SDHPEWILLCDTPTCNKGYHCSCLSPVLFYIPEGDWHCPPCQQEQLIAALERQLEQYDTLVAQKQ 1443
            .:|||.|||||  :|:.|||.:||.|.|..||:|:|.|||||.:.|...||.||:..|  ||.|:
Human   900 PNHPELILLCD--SCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLD--VALKK 960

  Fly  1444 QERILAEEQAERERQELEAATLAAKDENFKSEKEED-----EDDRDDMAVGKAEKVKRRRGDGRI 1503
            :||      |||.::.|....::.  ||....:|.|     |:.:.|....||..::|       
Human   961 KER------AERRKERLVYVGISI--ENIIPPQEPDFSEDQEEKKKDSKKSKANLLER------- 1010

  Fly  1504 NRRAAKRGTRRRRGNESDSSHRKSLGSGSRSGSGSDSSSDNSTSFSDSDDEPIYKLRKRRQINVS 1568
                  |.||.|:                                                 .:|
Human  1011 ------RSTRTRK-------------------------------------------------CIS 1020

  Fly  1569 YRLNEYDDLINSALKKEMDEVAGAGNLGRGKDISTIIEADKEKARRDDLPTEDEVGNKEDGEKDK 1633
            ||.:|:|:.|:.|::.::.|..| |.:|||||||||                  .|::       
Human  1021 YRFDEFDEAIDEAIEDDIKEADG-GGVGRGKDISTI------------------TGHR------- 1059

  Fly  1634 QKSKSSGSSPSSSEDEVPLKRSNKFKQPPA---KKKARKLTTLDVSSE-EDHGSDEDFKTSS--- 1691
                  |...|:..||.  ::.||..|..|   :||.|:|..||..|. ::..|:::||.|.   
Human  1060 ------GKDISTILDEE--RKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQ 1116

  Fly  1692 ----YSDEDTSQS-----ASGDSDS---SLEAYRRPGRGKKQRKAARRAARERRKDRKFVVEESD 1744
                .|||:..:|     ::.|||:   |....|.|.|..:|.:      |.|||..|....:.|
Human  1117 DEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSR------RLRRKTPKKKYSDDD 1175

  Fly  1745 ESEDEDQKRRTTKSKKKKDDS-DYTETETEDDDDNELSDNVDSADLCDDTTSESEDGAWNPSSKK 1808
            |.|:.::..|.::|....|.| |:.||.......|:........|      ||| ||:.....:.
Human  1176 EEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKED------SES-DGSQKSLRRG 1233

  Fly  1809 KKTVAAKK-----SNSSGGIARKSPKLKKLATQAEKKVKRLEYSDDDISESDLEEDDDDD----- 1863
            |:.....|     |.|......|:.:..:||.::::.|::...|.|:.||:|.||::::.     
Human  1234 KEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRK 1298

  Fly  1864 -----EEDEEGVPLSGKGSGKQPR--SQP--LKPTASSTLTGKGKGKGKAKKKKQVSSEEED--- 1916
                 |.|||....:..|...||.  |||  |.....||           ||..::.|:||:   
Human  1299 RLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQEST-----------KKPYRIESDEEEDFE 1352

  Fly  1917 -----GAASDDRTRTRGRRYAYIEDDDDSSDGGIKPG--VHRPDTPPEERQKFIQRQEEIKRMLA 1974
                 |:..|         |:.:   |..|..|..||  :......|.|:.:..:........||
Human  1353 NVGKVGSPLD---------YSLV---DLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLA 1405

  Fly  1975 EKNAEGAKIAATP--------RLTPLKSGVTASEK 2001
            .....|.:.|..|        |:|.|...|..||:
Human  1406 SNGTSGGQEAGAPEEEEDELLRVTDLVDYVCNSEQ 1440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8677NP_001286123.1 Ehrlichia_rpt 770..>1243 CDD:118064 102/501 (20%)
PHD_RSF1 1373..1419 CDD:277018 26/45 (58%)
Sox_C_TAD <2107..>2186 CDD:288887
RSF1NP_057662.3 WHIM1 98..148 CDD:292246 18/49 (37%)
WHIM2 150..182 CDD:292247 14/31 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 215..283 22/102 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 330..385 20/139 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..634 51/266 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..887 62/278 (22%)
PHD_RSF1 893..938 CDD:277018 26/46 (57%)
BAH 915..>968 CDD:295389 30/60 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 983..1007 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1063..1428 100/402 (25%)
CDC45 1093..>1171 CDD:280821 24/83 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_28PKK
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 195 1.000 Inparanoid score I3835
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007345
OrthoInspector 1 1.000 - - oto90974
orthoMCL 1 0.900 - - OOG6_108537
Panther 1 1.100 - - LDO PTHR10615
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5459
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.980

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