DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8677 and Rsf1

DIOPT Version :9

Sequence 1:	NP_001286123.1	Gene:	CG8677 / 35397	FlyBaseID:	FBgn0026577	Length:	2663	Species:	Drosophila melanogaster
Sequence 2:	XP_218939.4	Gene:	Rsf1 / 308839	RGDID:	1311245	Length:	1448	Species:	Rattus norvegicus

Alignment Length:	2169	Identity:	462/2169 - (21%)
Similarity:	754/2169 - (34%)	Gaps:	809/2169 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAASSAAAAAPTNPIPLPTDSISEECKDDDALTSTLHTCANDPDFAVICAFLQKFGKDLGL-NLP 64
            :||::|||.|...|...|                  .:|   |:|||:|:||:::|..|.| .||
  Rat     4 VAAAAAAAVAAMAPPGCP------------------GSC---PNFAVVCSFLERYGPLLDLPELP 47

  Fly    65 NFKHLQEWL------TNNNDVP-ELRDLHIKLLRKTRKTVHEKSWESALSKFCFGYSVQDAWEIE 122
             |..|:..|      ..:.:|| ||.:||:||:||..|:|....||..|.|.|..::...|||:|
  Rat    48 -FPELERVLQAPPPDIGHGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEME 111

  Fly   123 RFGYRNSSLKVKLRIFRELLESQFERNAKFRAHILTLNADTLRSEPIGRDRLGHAYWLTQDAHCN 187
            :.||...|::.||.:.:.|.|.||:.|.||:..|...:|||:|.:|||||:.|..||...|...|
  Rat   112 KKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHN 176

  Fly   188 LRIYQEHLDEE---IWQVVATNRDEFVNLISRLRG--NEVVLPSKDIGEADEDTSSSNSCHPKPP 247
            :|:|.|..|::   .|:.:..||:|....::.||.  :.|:|              .||...:.|
  Rat   177 VRMYIEEQDDQDGSSWKCIVRNRNELAETLALLRAQIDPVLL--------------KNSSQQEDP 227

  Fly   248 PPEQKEEEDDEEVGDEPEKTVPNLKIKLRSPEQEDQKSKKVKPLLISQAKLSSSASPAPTKKRSI 312
            ..|....||:|...||            .:|:||..:..:         |..:......::|||.
  Rat   228 SRESPTLEDEETKKDE------------ETPKQEASRGNE---------KTEADERSMDSRKRSA 271

  Fly   313 EDVDSSPTASQEEQQKKHRPTLLDTKRIKKPSRYESTKDEIEEESGEEDEEEEDEEDSELDEGEE 377
            .:....|....|:..:|....|....:::||......|..|.|||
  Rat   272 ANALEGPAVKIEKADEKELVKLPVIVKLEKPVPETEDKKIIREES-------------------- 316

  Fly   378 EEDVDSAAADIEEDDDEEDTGEPIEDPTIVVQGQGSGLDCEAIPYNLIGNFDYEDDLEIGEAIAD 442
                          |..::..:||:     |:.:    :|...|.:|.|:.:     .:|
  Rat   317 --------------DSFKENVKPIK-----VEAK----ECRVDPKDLKGSLE-----RLG----- 348

  Fly   443 PMLHVIGQGWGTDCLVGNGKNEASVEETSTRTSEPKATFFFGEPGCLKLSPMKQTSKPEAKRGIF 507
                                           :.||:...|
  Rat   349 -------------------------------SQEPERADF------------------------- 357

  Fly   508 DSLSEEKTNGESEKCIVNTPPRNGSELTKTLGDSEETASASAATLEETNICQEANVNKISDDQIK 572
                                   ||.:..:...:|::.       |||        .|:.:||..
  Rat   358 -----------------------GSNIKSSQDITEKST-------EET--------EKLKNDQQA 384

  Fly   573 KKESVPVAKRNIQDSTISVIEKNEEISKGRTESEAIEEGVRNRTEVSVLQNNSNESDNSSIQTQD 637
            |   :|:.||.|
  Rat   385 K---IPLKKREI----------------------------------------------------- 393

  Fly   638 QHKVPADLNNTKKPVTEKCVLESGTVEDKLVINHQQISTNALDTACDEKLSCETESPVPNQHDSK 702
                                                            |||.:.:|||...   .
  Rat   394 ------------------------------------------------KLSDDFDSPVKGH---L 407

  Fly   703 MKSEQETATSAKESVSESSPTDGEDETAKSKCLIDPYA--------GKTNDKGIIINKIDKAEGV 759
            .||...|....|:.|.:      |:||.|....|...:        |:.||        ||....
  Rat   408 CKSATPTKECLKDDVKQ------EEETCKRVSTISALSHEGKQLMNGEMND--------DKVTAS 458

  Fly   760 IKTLLQDDPPKDISKSETNTTCLEINISPSAEHRISEKVQTIEPSTSQNLLFEDNGKSGEVDGKS 824
            :||                                 |:::|....|.     ||:......||.:
  Rat   459 LKT---------------------------------EQLETQLCHTK-----EDSSSIPAKDGSA 485

  Fly   825 RTSGA-VEEISK--TSTLLNRKRRLNDSQSALRNSTSESEVHEEEPQDDDPTLDDLDVGGKRIKM 886
            ...|: ||.::.  |||..:...:......|:..|.|:.|.|.::.:.::|...::|:   .::.
  Rat   486 GLEGSGVECLNSVLTSTKTSELEKEVSLGKAVDGSASDVESHSQKGRGEEPGPPNMDM---PLEP 547

  Fly   887 RPKTTNAESRRKVEAQK---TQIEE-TTSSSGEDDARIRRKCIAPHTKTKPTLEEIIERKLKKSI 947
            ..|||:...:..:.|.:   |:||| ...|.||:           ||.....||: :|:..|.|:
  Rat   548 SEKTTDLSLKSTLSATESCPTKIEEKAPKSKGEN-----------HTAGIECLEK-VEKAKKTSV 600

  Fly   948 EMDLPEKTTEKVMEMPTQLMQKTREATPPIISLSPQKKTPITKPLKKNLLTQLRQEES-----EE 1007
            :.|:                               |:.:||.:.:.:.   .|..|||     .|
  Rat   601 DKDI-------------------------------QRLSPIPEEVVRG---PLESEESGLCEVAE 631

  Fly  1008 ETIPRKRTNSETLVPAIPASNVLCQPDERHRKRRSSEDANEAFSKESSPTEVPPSAVSEKLKRNN 1072
            ..:|.:.|.::                   .|:.|.:...:..|:.||..:...:|..:.|:.|:
  Rat   632 TPLPLEMTGAK-------------------EKQTSEKKGVDCLSRGSSEGQSLENASPDILRENS 677

  Fly  1073 EQDIQE--EVEDPLAMSVKDSLRSAKDQSPVPEGSARRSGRRGGPAVIHSELPQPKRTRGGARDK 1135
            |....|  ::::.....|:|:.::        :||.::           ::......:.|.:...
  Rat   678 ESSRVEMAKLDNAQTSGVEDTSQT--------KGSVQK-----------NKCKYKLVSEGNSTAS 723

  Fly  1136 MQPEVNAELKQESEDDEKISTKIKSEAKDDPAPESPENRKKPEEKPIKEEPNEEPKPKVGR--GR 1198
            ...|:.:|.|:|.   .|::.:|.|..|....|....:.:..|||..|    ||.|..|||  .|
  Rat   724 ENTEITSERKKEG---IKLTIRISSRKKKPDCPPQIVDSESKEEKAGK----EEEKTSVGRTLRR 781

  Fly  1199 GPRKKREVDTTNIIETNDSETPVRQSRRIAQQKIKEEAERRKQEEVALRT--MKQELKKKKKAEK 1261
            .||..|  .|..:.|..|.:         |.:|..|..|..:.|..:|:|  .|:.|||.:|
  Rat   782 SPRISR--PTAKVAEIRDQK---------ADKKRAEGEEGVEGETTSLQTADKKEHLKKAEK--- 832

  Fly  1262 EADPTVLEPSGEESESEASEAEEEARNKKKKKCPG---KDGWSSDSEEQPESEEEEEEPPHYETD 1323
                        ::.|:||    :.:.|.|.:..|   :..|...|.::.|..|.::.....|.:
  Rat   833 ------------DTNSKAS----KVKPKGKVRWTGSRTRGRWKYSSNDESEGSESDKSSAASEEE 881

  Fly  1324 PGSPLFRSDHEFSPESELEDESQVVPMKRARTVRKENADDLEEEDAEEACQKCGKSDHPEWILLC 1388
            .|.               |.|..|:|                  |.:|.|:|||..:|||.||||
  Rat   882 EGK---------------ESEEAVLP------------------DDDEPCKKCGLPNHPELILLC 913

  Fly  1389 DTPTCNKGYHCSCLSPVLFYIPEGDWHCPPCQQEQLIAALERQLEQYDTLVAQKQQERILAEEQA 1453
            |  :|:.|||.:||.|.|..||:|:|.|||||.:.|...||.||:..|  ||.|::||      |
  Rat   914 D--SCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLD--VALKKKER------A 968

  Fly  1454 ERERQELEAATLAAKDENFKSE---KEEDEDDRDDMAVGKAEKVKRRRGDGRINRRAAKRGTRRR 1515
            ||.::.|....::.::.....|   .|:.|:.:.|....||..::|             |.||.|
  Rat   969 ERRKERLVYVGISIENIIPPQEPEFSEDQEEKKKDAKKSKANVLER-------------RSTRTR 1020

  Fly  1516 RGNESDSSHRKSLGSGSRSGSGSDSSSDNSTSFSDSDDEPIYKLRKRRQINVSYRLNEYDDLINS 1580
            :                                                 .:|||.:|:|:.|:.
  Rat  1021 K-------------------------------------------------CISYRFDEFDEAIDE 1036

  Fly  1581 ALKKEMDEVAGAGNLGRGKDISTIIEADKEKARRDDLPTEDEVGNKEDGEKDKQKSKSSGSSPSS 1645
            |::.::.|..| |.:|||||||||                  .|::             |...|:
  Rat  1037 AIEDDIKEADG-GGVGRGKDISTI------------------TGHR-------------GKDIST 1069

  Fly  1646 SEDEVPLKRSNKFKQPPA---KKKARKLTTLDVSSE-EDHGSDEDFKTSS-------YSDEDTSQ 1699
            ..||.  ::.||..|..|   :||.|:|..||..|. ::..|:::||.|.       .|||:..:
  Rat  1070 ILDEE--RKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDE 1132

  Fly  1700 S-----ASGDSDSSLEAYRRPGRGKKQRKAARRAARERRKDRKFVVEESDESEDEDQKRRTTKSK 1759
            |     ::.|||:..          ..|:..|..:|..|:.|:.              ||.|:.|
  Rat  1133 SEEEPPSNEDSDTDF----------CSRRLRRHPSRPMRQSRRL--------------RRKTQKK 1173

  Fly  1760 KKKDDSDYTETETEDDDDNELSDNVDSADLCDDTTSESEDGAWNPSSK-KKKTVAAKKSNSSGGI 1823
            |..||.   |.|.|:::::|.:.....:|..||.:.|..:.....|.: :|:.:..|:.:.|.|.
  Rat  1174 KYSDDD---EEEEEEEEESEENSRDSESDFSDDFSDEFVETRRRRSRRNQKRQINYKEDSESDGS 1235

  Fly  1824 ARKSPKLKKLATQAEKKVKRLEYSDDDISESDLEEDDDDDEEDEEGVPLSGKGSGKQPRSQPLKP 1888
            .:...:.|::     ::|.:...|..:..||.:.::.:|||..:|
  Rat  1236 QKSLRRGKEI-----RRVHKRRLSSSESEESYMSKNSEDDELTKE-------------------- 1275

  Fly  1889 TASSTLTGKGKGKGKAKKKKQVSSEEEDGAASDDRTRTRGRRYAYIEDDDDSSDGGIKPGVH-RP 1952
             :..::..:|:..|:..:..:  .|||:|..|    |.|..|   ||.|::|.|     ..| ..
  Rat  1276 -SKRSIRKRGRSTGEYSEADE--EEEEEGKPS----RKRLHR---IETDEESCD-----SAHGDA 1325

  Fly  1953 DTPPEERQKFI--QRQEEIKRML-----AEKNAEGAKIAATP---RLTPLKSGVTASEKRTPGKA 2007
            |.|..|.|..:  ..||..|:..     .|::.|......:|   .|..|.|    :..::||||
  Rat  1326 DQPARESQASVLPSEQESSKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPS----TNGQSPGKA 1386

  Fly  2008 ASGDSLSTVPLSVIRQAKVLDIDYLQRKGETIGDLDDVDESELDDAELPDDLPEDMEDAIARMVE 2072
            .                                      |:.:..|......|:|...|.|.:..
  Rat  1387 I--------------------------------------ENLMGKATEKSQTPKDNGTASANLAP 1413

  Fly  2073 EEEQFSAEVAARELPGAEEVLRTT 2096
            .......||.|.| ...:|:||.|
  Rat  1414 NGTSGGQEVGAPE-EDEDELLRVT 1436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8677	NP_001286123.1	Ehrlichia_rpt	770..>1243	CDD:118064	94/488 (19%)
		PHD_RSF1	1373..1419	CDD:277018	26/45 (58%)
		Sox_C_TAD	<2107..>2186	CDD:288887
Rsf1	XP_218939.4	WHIM1	102..152	CDD:292246	18/49 (37%)
		WHIM2	154..186	CDD:292247	14/31 (45%)
		PHD_RSF1	897..942	CDD:277018	26/46 (57%)
		BAH	919..>972	CDD:295389	30/60 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28PKK
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007345
OrthoInspector	1	1.000	-	-		oto98070
orthoMCL	1	0.900	-	-		OOG6_108537
Panther	1	1.100	-	-	LDO	PTHR10615
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.900