DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8677 and CECR2

DIOPT Version :9

Sequence 1:	NP_001286123.1	Gene:	CG8677 / 35397	FlyBaseID:	FBgn0026577	Length:	2663	Species:	Drosophila melanogaster
Sequence 2:	NP_001276976.1	Gene:	CECR2 / 27443	HGNCID:	1840	Length:	1464	Species:	Homo sapiens

Alignment Length:	1602	Identity:	324/1602 - (20%)
Similarity:	465/1602 - (29%)	Gaps:	637/1602 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1262 EADPTVLEPSGEE-----------------------SESEASEAEEEARNKKKKKCPGKDGWSSD 1303
            :||...:||.||:                       |..|.|.:.|....|.....|||.|....
Human   138 DADSLRVEPLGEDNSGALYWYFYGTRMYKEDPVQGKSNGELSLSRESEGQKNVSSIPGKTGKRRG 202

  Fly  1304 --------SEEQPESEEEEE-----EPP--HYETDPGSP----LFRSDHEFSPESELEDESQVVP 1349
                    .||...||::||     ||.  |....||..    |.:::.|:         .||..
Human   203 RPPKRKKLQEEILLSEKQEENSLASEPQTRHGSQGPGQGTWWLLCQTEEEW---------RQVTE 258

  Fly  1350 MKRARTVRKEN------ADDLEEEDAEEACQKCGKSD-------HPEWILLCDTPTCNKGYHCSC 1401
            ..|.||..:|.      ::|...|......|| ||..       ||.|:          ..|.|
Human   259 SFRERTSLRERQLYKLLSEDFLPEICNMIAQK-GKRPQRTKAELHPRWM----------SDHLS- 311

  Fly  1402 LSPVLFYIPEGDWHCPPCQQEQ--LIAALERQLEQYDTLVAQKQQERILAEEQAERERQELEAAT 1464
                          ..|.:||:  ::..:|:          ||::|.       |.|||.|.|..
Human   312 --------------IKPVKQEETPVLTRIEK----------QKRKEE-------EEERQILLAVQ 345

  Fly  1465 LAAKDENFKSEKEEDEDDRDDMAVGKAEKVKRRRGDGRINRRAAKRGTRRRR------GNE--SD 1521
            ...:::..|.|::.:.:          ||||      .:..||.:|..|..|      |.|  .:
Human   346 KKEQEQMLKEERKRELE----------EKVK------AVEDRAKRRKLREERAWLLAQGKELPPE 394

  Fly  1522 SSHRKSLGSGSRSGSGSDSSSDNSTSFSDSDDEPIYKLRKRRQINVSYRLNEYDDLINSALKKEM 1586
            .||.                            :|...:|:.::....:.|:  ||.  :|:.|.:
Human   395 LSHL----------------------------DPNSPMREEKKTKDLFELD--DDF--TAMYKVL 427

  Fly  1587 DEVAGAGNLGRGKDISTIIEADKEKARRDDLPTEDEVGNKEDGEKDKQKSKSSGSSPSSSEDEVP 1651
            |.|                     ||.:|..|..:.|                      .|...|
Human   428 DVV---------------------KAHKDSWPFLEPV----------------------DESYAP 449

  Fly  1652 LKRSNKF---KQPPAKKKARKLTTLDVSSEED------HGSDEDF----KT-----SSYSDEDTS 1698
                |.:   |.|           :|:||.|.      :.:.|:|    ||     ..|:.|.:.
Human   450 ----NYYQIIKAP-----------MDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSE 499

  Fly  1699 QSASGDSDSSLEAYRRPGRGKKQRKAARRAARERRKDRKFVVEESDESED----EDQKRRTTKSK 1759
            .:...|   :||            :...||..     :.|..|:.|..|:    ||:||...:|:
Human   500 YTKMSD---NLE------------RCFHRAMM-----KHFPGEDGDTDEEFWIREDEKREKRRSR 544

  Fly  1760 KKKDDSDYTETETEDDDDNELSDNVDSADLCDDTTSESEDGAWNPSSKKKKTVAAKKSNSSGGIA 1824
            ..:....:..|.:.|.:.                           ||:|::.:      .:||
Human   545 AGRSGGSHVWTRSRDPEG---------------------------SSRKQQPM------ENGG-- 574

  Fly  1825 RKSPKLKKLATQAEKKVKRLEYSDDDISESDLEEDDDDDEEDEEGV--PLSGKGSGKQ-PRSQPL 1886
                  |.|     ...:|...|.||.|.|..:...:....:..|.  ||...|:..| |....:
Human   575 ------KSL-----PPTRRAPSSGDDQSSSSTQPPREVGTSNGRGFSHPLHCGGTPSQAPFLNQM 628

  Fly  1887 KPTASSTLTGKGKGKGKAKKKKQVSSEEEDGAASDDRTRTRGRRYAYIEDDDDSSDGGIKPGVHR 1951
            :|....|.   |..:|                 ||..|       .|      .|.|..:|   .
Human   629 RPAVPGTF---GPLRG-----------------SDPAT-------LY------GSSGVPEP---H 657

  Fly  1952 PDTPPEERQKFIQRQEEIKRMLAEKNAEGAKIAATPRLTPLKSGVTASEKRTPGKAASGDSLSTV 2016
            |..|.::||.|..:.           ..|......|||.      |..||:..|......::...
Human   658 PGEPVQQRQPFTMQP-----------PVGINSLRGPRLG------TPEEKQMCGGLTHLSNMGPH 705

  Fly  2017 PLSVIRQAKVLDIDYLQRKGETIGDLDDVDESELDDAEL---------------PDDLPEDMEDA 2066
            |.|:             :.|:..|  ...|.|....|:.               |.|.||..|..
Human   706 PGSL-------------QLGQISG--PSQDGSMYAPAQFQPGFIPPRHGGAPARPPDFPESSEIP 755

  Fly  2067 IARMVEEEEQFSA---------EVAARELP-GAEEVLRTTPSKSKQ--------TSRVMPESPAQ 2113
            .:.|....:..:.         ..|..:.| |.:|.....|..|.|        .||||......
Human   756 PSHMYRSYKYLNRVHSAVWNGNHGATNQGPLGPDEKPHLGPGPSHQPRTLGHVMDSRVMRPPVPP 820

  Fly  2114 NSAPSTSGLQEPHRKRLPMPT---MHPPLLRHQFPISAGPSHSPASL--VPPHAAQGM------- 2166
            |.....||.. ||    .:|:   |.||.......:...|..:|:||  .|..|.:|:
Human   821 NQWTEQSGFL-PH----GVPSSGYMRPPCKSAGHRLQPPPVPAPSSLFGAPAQALRGVQGGDSMM 880

  Fly  2167 ---HPMLQRHLSQTVPPPQAMHLLQNALSAPLGQPLGCGNYGSGPNSAQHLPLVMSMPSAAAAAA 2228
               ..:..:.||..|.||              |.|.           ..|.|....:|......|
Human   881 DSPEMIAMQQLSSRVCPP--------------GVPY-----------HPHQPAHPRLPGPFPQVA 920

  Fly  2229 HLMQSAVASATARPVETASGNPASDPKPRGRRKKVTPLRDQLQKQQTAAAVTAATSSTTPGSAPS 2293
            |.|     |.|....:.|.|||...|:   ..:...|..||
Human   921 HPM-----SVTVSAPKPALGNPGRAPE---NSEAQEPENDQ------------------------ 953

  Fly  2294 EKVKAQPLFKPH-EDAAPSAPASQASVITRMPSLLPPAH-------------------------- 2331
                |:||  |. |:..|....|:...:|::|...||..
Human   954 ----AEPL--PGLEEKPPGVGTSEGVYLTQLPHPTPPLQTDCTRQSSPQERETVGPELKSSSSES 1012

  Fly  2332 --------GRNHGPPSGLYPSSA--DLARFYGQVANQQPIP--AVPGSRSPSSTSG--------- 2375
                    |:|..|....||..|  ...|....||::..:.  .|.|..||..:.|
Human  1013 ADNCKAMKGKNPWPSDSSYPGPAAQGCVRDLSTVADRGALSENGVIGEASPCGSEGKGLGSSGSE 1077

  Fly  2376 ----PPRHLLRPQMP-----PGLPPPHASLRPTYGPPPPLRGSGPPTSTPSTTTNSRPAYLHG-- 2429
                |....|:..||     ...||                 |..|..|..|.:...|.|:.|
Human  1078 KLLCPRGRTLQETMPCTGQNAATPP-----------------STDPGLTGGTVSQFPPLYMPGLE 1125

  Fly  2430 -----AEHHGGPS----GPPMGGVFSSGPPPARHATPHLNPYRAPPIYGNPNYSPRLGGAPGTGS 2485
                 |.:|..|.    ||.||     |..||.|      |...|| .|..:..|..||.|   .
Human  1126 YPNSAAHYHISPGLQGVGPVMG-----GKSPASH------PQHFPP-RGFQSNHPHSGGFP---R 1175

  Fly  2486 MRPGAVDYVAGPRGYSPYGYYPPPPPLSTPSAHAATSSVIVSAPHTLTPTNHSVPTLTHGKTPPQ 2550
            .||        |:|.. |.|:|||    .||.|....:...:.|.:.:.....:    |    ||
Human  1176 YRP--------PQGMR-YSYHPPP----QPSYHHYQRTPYYACPQSFSDWQRPL----H----PQ 1219

  Fly  2551 QTPTQSSGPPPAAAPPPTITSETSSHKPPLASVITSKKLTTLEAYPIRKSPIA--VVADVSGPA- 2612
            .:|   ||||.:..|||   ....|.|..:||:...:.|......|.|...:|  |..|...|.
Human  1220 GSP---SGPPASQPPPP---RSLFSDKNAMASLQGCETLNAALTSPTRMDAVAAKVPNDGQNPGP 1278

  Fly  2613 ---------EPTRSPAPIAEEDSGSAHDTRAPSSATGTAVVG 2645
                     |...||....:.|:.:|...|..|.:....:.|
Human  1279 EEEKLDESMERPESPKEFLDLDNHNAATKRQSSLSASEYLYG 1320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8677	NP_001286123.1	Ehrlichia_rpt	770..>1243	CDD:118064
		PHD_RSF1	1373..1419	CDD:277018	9/52 (17%)
		Sox_C_TAD	<2107..>2186	CDD:288887	22/93 (24%)
CECR2	NP_001276976.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..241		20/70 (29%)
		WHIM3	244..284	CDD:292248	10/48 (21%)
		Bromo_gcn5_like	418..518	CDD:99941	31/179 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..684		42/240 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	776..805		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..1033		33/182 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1145..1239		38/135 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1300		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1422..1464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000