DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8677 and Rsf1

DIOPT Version :9

Sequence 1:	NP_001286123.1	Gene:	CG8677 / 35397	FlyBaseID:	FBgn0026577	Length:	2663	Species:	Drosophila melanogaster
Sequence 2:	NP_001074736.1	Gene:	Rsf1 / 233532	MGIID:	2682305	Length:	1441	Species:	Mus musculus

Alignment Length:	2131	Identity:	455/2131 - (21%)
Similarity:	743/2131 - (34%)	Gaps:	801/2131 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AASSAAAAAPTNPIPLPTDSISEECKDDDALTSTLHTCANDPDFAVICAFLQKFGKDLGL-NLPN 65
            ||::|||||...|...|                  .:|   |:|||:|:||:::|..|.| .||
Mouse     6 AAAAAAAAAAMAPPGCP------------------GSC---PNFAVVCSFLERYGPLLDLPELP- 48

  Fly    66 FKHLQEWL------TNNNDVP-ELRDLHIKLLRKTRKTVHEKSWESALSKFCFGYSVQDAWEIER 123
            |..|:..|      ..|.:|| ||.:||:||:||..|:|....||..|.|.|..::...|||:|:
Mouse    49 FPELERVLQAPPPDIGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEK 113

  Fly   124 FGYRNSSLKVKLRIFRELLESQFERNAKFRAHILTLNADTLRSEPIGRDRLGHAYWLTQDAHCNL 188
            .||...|::.||.:.:.|.|.||:.|.||:..|...:|||:|.:|||||:.|..||...|...|:
Mouse   114 KGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNV 178

  Fly   189 RIYQEHLDEE---IWQVVATNRDEFVNLISRLRGNEVVLPSKDIGEADEDTSSSNSCHPKPPPPE 250
            |:|.|..|::   .|:.:..||:|....::.|:.
Mouse   179 RMYIEEQDDQDGSSWKCIVRNRNELAETLALLKA------------------------------- 212

  Fly   251 QKEEEDDEEVGDEPEKTVPNLKIKLRSPEQEDQKSKKVKPLLISQAKLSSSASPAPTKKRSIEDV 315
                                                ::.|:|:.
Mouse   213 ------------------------------------QIDPVLLK--------------------- 220

  Fly   316 DSSPTASQEEQQKKHRPTLLDTKRIKKPSRYESTKDEIEEESGEEDEEEEDEEDSELDE--GEEE 378
                .:||:|...:..|||                   |:|..::|||...:|.|:.:|  |.:|
Mouse   221 ----NSSQQEDSSRESPTL-------------------EDEETKKDEETPKQEASKENEKTGADE 262

  Fly   379 EDVDSAAADIEEDDDEEDTGEPIEDPTIVVQGQGSGLDCEAIPYNLIGNFDYEDDLEIGEAIADP 443
            ..|||...         .....:|:|.:
Mouse   263 RSVDSGKC---------SAASALEEPAV------------------------------------- 281

  Fly   444 MLHVIGQGWGTDCLVGNGKNEASVEETSTRTSEPKATFFFGEPGCLKL-SPMKQTSKPEAKRGIF 507
                              |.|.:.|:...:.           |..:|| .|:.:|.:.:..|...
Mouse   282 ------------------KTEKADEKELAKL-----------PVIVKLEKPLPETEEKKIIREES 317

  Fly   508 DSLSE--EKTNGESEKCIVNTPPRNGSELTKTLGDSEETASASAATLEETNICQEA--NVNKISD 568
            ||..|  :....|:::|..:.....||  .:.||..|...:...:.::..:|.:::  ...|:.:
Mouse   318 DSFKENVKPIKVEAKECRADPKDLKGS--LERLGSQEPERADFGSNIKSQDIIEKSTEETEKLKN 380

  Fly   569 DQIKKKESVPVAKRNIQDSTISVIEKNEEISKGRTESEAIEEGVRNRTEVSVLQNNSNESDNSSI 633
            ||..|   :|:.||.|
Mouse   381 DQQAK---IPLKKREI------------------------------------------------- 393

  Fly   634 QTQDQHKVPADLNN-TKKPVTEKCVLESGTVEDKLVINHQQISTNALDTACDEKLSCETESPVPN 697
                  |:..|.:: .|.|:                                    |::.:|...
Mouse   394 ------KLSDDFDSPVKGPL------------------------------------CKSATPTKE 416

  Fly   698 QHDSKMKSEQETATSAKESVSESSPTDGEDETAKSKCLIDPYAGKTNDKGIIINKIDKAEGVIKT 762
            .....:|.|:||.    :.||..|....|     .|.|::   |:.||..:|.|
Mouse   417 VLKDDIKQEEETC----KRVSTISALSHE-----GKQLVN---GEINDDKVIPN----------- 458

  Fly   763 LLQDDPPKDISKSETNTTCLEINISPSAEHRISEKVQTIEPSTSQNLLFEDNGKSGEVDGKSRTS 827
                          ..|..:||.:..:.|...|      .|:...|...|.||
Mouse   459 --------------FKTEQMEIQLCDTKEDSAS------IPAKDGNACMEGNG------------ 491

  Fly   828 GAVEEISKTSTLLNRKRRLNDSQSALRNSTSESEVHEEEP--QDDDPTLDDLDVGGKRIKM-RPK 889
                               .:..:::..||..||:.:|.|  :..|.::.|::...::.:: .|.
Mouse   492 -------------------TECLNSVITSTKTSELEKEAPLGKGIDSSVPDIESLSQKARLEEPG 537

  Fly   890 TTNAESRRKVEAQKT--QIEETTSSSGEDDARIRRKCIAPHTKTK---PTLE--EIIERKLKKSI 947
            ..|.:...:...:.|  .::.|.|::.....::..|  ||.:|::   |.:|  |.:|:..|.||
Mouse   538 LLNMDMPLEPSEKATDLSLKPTLSATEPCSTKVEEK--APRSKSENHTPGIECLERVEKAKKTSI 600

  Fly   948 EMDLPEKTTEKVMEMPTQLMQKTREATPPIISLSPQKKTP---ITKPLKKNLLTQLRQEESEEET 1009
            :.|:     :|:..:|.::::.         :|..:|..|   ...||..::.....::.||::.
Mouse   601 DKDI-----QKLSPIPEEVVRG---------ALESEKSGPCEVAETPLPLSMAGAKEKQTSEKKD 651

  Fly  1010 IPRKRTNSETLVPAIPASNVLCQPDERHRKRRSSEDANEAFSKESSPTEVPPSAVSEKLKRNNEQ 1074
            :...|.:||:                     :|.|:|:....||.|     .|:..|..|.:|.|
Mouse   652 VDCSRGSSES---------------------QSLENASPEILKEDS-----ESSREEVAKLDNAQ 690

  Fly  1075 DIQEEVEDPLAMSVKDSLRSAKDQSPVPEGSARRS-------GRRGGPAVIHSELPQPKRTRGGA 1132
                              .|..:.:...:||.:::       ..|...|   ||
Mouse   691 ------------------TSGMEDTSETKGSVQKNKFKYKLVSERNSTA---SE----------- 723

  Fly  1133 RDKMQPEVNAELKQESEDDEKISTKIKSEAKDDPAPESPENRKKPEEKPIKEEPNEEPKPKVGR- 1196
                ..|:.:|.|:|.   .|::.:|.|..|....|....:.:..|||..|    ||.|..|||
Mouse   724 ----NTEITSERKKEG---IKLTIRISSRKKKPDCPPQTVDSESKEEKAGK----EEEKASVGRT 777

  Fly  1197 -GRGPRKKREVDTTNIIETNDSETPVRQSRRIAQQKIKEEAERRKQEEVALRTMKQELKKKKKAE 1260
             .|.||..                  |.:.::|:.::::..:||...|..:
Mouse   778 LRRSPRIS------------------RPTAKVAEIRVQKADKRRADGEDGV-------------- 810

  Fly  1261 KEADPTVLEPSGEESESEASEAEEEARNKKKKKCP-GKDGWSS---------DSEEQPESEEEEE 1315
             |.:|..|:.:  :.:....:||::..:|..|..| ||..|:.         .|.::.|..|.::
Mouse   811 -EGEPASLQTA--DKKDHLKKAEKDTNSKASKVKPKGKVRWTGSRTRGRWKYSSNDESEGSESDK 872

  Fly  1316 EPPHYETDPGSPLFRSDHEFSPESELEDESQVVPMKRARTVRKENADDLEEEDAEEACQKCGKSD 1380
            .....|.:.|.               |.|..|:|                  |.:|.|:|||..:
Mouse   873 SSAALEEEEGK---------------EGEEAVLP------------------DDDEPCKKCGLPN 904

  Fly  1381 HPEWILLCDTPTCNKGYHCSCLSPVLFYIPEGDWHCPPCQQEQLIAALERQLEQYDTLVAQKQQE 1445
            |||.|||||  :|:.|||.:||.|.|..||:|:|.|||||.:.|...||.||:..|  ||.|::|
Mouse   905 HPELILLCD--SCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLD--VALKKKE 965

  Fly  1446 RILAEEQAERERQELEAATLAAKDENFKSE---KEEDEDDRDDMAVGKAEKVKRRRGDGRINRRA 1507
            |      |||.::.|....::.::.....|   .||.|:.:.|....||..::|
Mouse   966 R------AERRKERLVYVGISIENIIPPQEPEFSEEQEEKKKDAKKSKANALER----------- 1013

  Fly  1508 AKRGTRRRRGNESDSSHRKSLGSGSRSGSGSDSSSDNSTSFSDSDDEPIYKLRKRRQINVSYRLN 1572
              |.||.|:                                                 .:|||.:
Mouse  1014 --RSTRTRK-------------------------------------------------CISYRFD 1027

  Fly  1573 EYDDLINSALKKEMDEVAGAGNLGRGKDISTIIEADKEKARRDDLPTEDEVGNKEDGEKDKQKSK 1637
            |:|:.|:.|::.::.|..| |.:|||||||||                  .|::
Mouse  1028 EFDEAIDEAIEDDIKEADG-GGVGRGKDISTI------------------TGHR----------- 1062

  Fly  1638 SSGSSPSSSEDEVPLKRSNKFKQPPA---KKKARKLTTLDVSSE-EDHGSDEDFKTSS------- 1691
              |...|:..||.  ::.||..|..|   :||.|:|..||..|. ::..|:::||.|.
Mouse  1063 --GKDISTILDEE--RKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFV 1123

  Fly  1692 YSDEDTSQS-----ASGDSDS---SLEAYRRPGRGKKQRKAARRAARERRKDRKFVVEESDESED 1748
            .|||:..:|     ::.|||:   |....|.|.|..:|.:      |.|||..|....:.||.|:
Mouse  1124 VSDENPDESEEEPPSNEDSDTDFCSRRLRRHPSRPMRQSR------RLRRKTPKKKYSDDDEEEE 1182

  Fly  1749 EDQKRRTTKSKKKKDD--SDYTETETEDDDDNELSDNVDSADLCDDTTSESEDGAWNPSSKKKKT 1811
            |.::..........||  .|:.||.......|:........|      ||| ||:.....:.|:.
Mouse  1183 ESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKED------SES-DGSQKSLRRGKEI 1240

  Fly  1812 VAAKK-----SNSSGGIARKSPKLKKLATQAEKKVKRLEYSDDDISESDLEEDDDDD-------- 1863
            ....|     |.|......|:.:..:|..::::.|::...|.||.||:|  |||:::
Mouse  1241 RRVHKRRLSSSESEESFMSKNSEDDELTKESKRSVRKRGRSTDDYSEAD--EDDEEEGKPSRKRL 1303

  Fly  1864 ---EEDEEGVPLSGKGSGKQPR--SQPLKPTASSTLTGKGKGKGKAKKKKQVSSEEED------G 1917
               |.|||... :..|...||.  |||      |.|..:   :..:||..::.|:||:      |
Mouse  1304 HRIETDEESCD-NAHGDADQPARDSQP------SALPSE---QESSKKPYRIESDEEEDFENKVG 1358

  Fly  1918 AASDDRTRTRGRRYAYIEDDDDSSDGGIKPGVHRPDTPPEERQKFIQRQEEIKRMLAEKNAEGAK 1982
            :..|         |:.:   |..|..|..||            |.|   |.:.....||:.
Mouse  1359 SPLD---------YSLV---DLPSTNGQSPG------------KAI---ENLMGKATEKSQ---- 1392

  Fly  1983 IAATPRLTPLKSGVTASEKRTPGKAASGDSLSTVPLSVIRQAKVLD-IDYL 2032
                   ||..:| |||....|...:.|..:...........:|.| :||:
Mouse  1393 -------TPKDNG-TASASLAPNGTSGGQEVGAPEEDEDELLRVTDLVDYV 1435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8677	NP_001286123.1	Ehrlichia_rpt	770..>1243	CDD:118064	91/494 (18%)
		PHD_RSF1	1373..1419	CDD:277018	26/45 (58%)
		Sox_C_TAD	<2107..>2186	CDD:288887
Rsf1	NP_001074736.1	WHIM1	103..153	CDD:292246	18/49 (37%)
		WHIM2	155..187	CDD:292247	14/31 (45%)
		PHD_RSF1	896..941	CDD:277018	26/46 (57%)
		BAH	918..>971	CDD:295389	30/60 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4019
Isobase	1	0.950	-	0	Normalized mean entropy	S11781
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007345
OrthoInspector	1	1.000	-	-		oto94558
orthoMCL	1	0.900	-	-		OOG6_108537
Panther	1	1.100	-	-	LDO	PTHR10615
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5459
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.030