Protein Alignment Atg18b and Wipi2

DIOPT Version :10

• Sequence 1: NP_610100.1
• Gene: Atg18b / 35396
• FlyBaseID: FBgn0032935
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_848485.1
• Gene: Wipi2 / 74781
• MGIID: 1923831
• Length: 445
• Species: Mus musculus
• Alignment Length: 383
• Identity: 187/383 - (48%)
• Similarity: 246/383 - (64%)
• Gaps: 35/383 - (9%)

  Fly     7 NFNQDFTSLSVLSPTGLRLFSISSQDKVEEIFAKDNTEQIRIVERLFNSSLVVLVTAQKPNCLKM 71
            |||||.|||:|.|.:|.:.||:||.||:|:|:...:||.:.||||||:||||.:|:.:.|..||:
Mouse    19 NFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKV 83

  Fly    72 LHFKKKQDICNCFYPSEILCVRMNRQRLIVCLAESIHIHDIRDMKILHSIENIAPNEQGLCALSL 136
            .||||..:|||..|.:.||.|::|||||||||.||::||:|||||:||:|....||..||||||:
Mouse    84 CHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSI 148

  Fly   137 NS---HLAFPVCQTSGELRIFNASKLRTGMTIRAHDTSLSALAFSPSGALLATASERGTVIRVFC 198
            |:   :||:|...:.||:::|:...||....|.|||:.|:||||..||..||||||:|||||||.
Mouse   149 NNDNCYLAYPGSASIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFS 213

  Fly   199 VKNGQRVQEFRRGVS-CVRIASLVFSASGDFLCASSNTETVHVFKIDTRAVETVELKAIADVAAK 262
            :..||::.||||||. ||.|.||.||..|.||.|||||||||:||:
Mouse   214 IPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKL------------------- 259

  Fly   263 SENSAKEAVASTAAEESCRPVASWGGMFSKAV--SSLLLPTQVSEVLAQDRSFATVQLAQGGLKH 325
                  |||.....||.    .:|.|.|.|.:  |:..||:||:|:..|.|:||||:|...|.|:
Mouse   260 ------EAVREKPPEEP----TTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKN 314

  Fly   326 ICALTRVQKEPRLLIACEDGFLYVHEFPAERGGPCKLMSVHDLRGALEDVIELELSES 383
            ||:||.:||.||||:...||:||::....:.||.|.||..|.|.|::|...|:..|.|
Mouse   315 ICSLTTIQKIPRLLVGASDGYLYMYNLDPQEGGECALMRQHRLDGSMETTSEIVDSAS 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg18b	NP_610100.1	WD40 repeat	79..122	CDD:293791	27/42 (64%)
		WD40 repeat	130..166	CDD:293791	15/38 (39%)
		WD40	<149..>251	CDD:441893	58/102 (57%)
		WD40 repeat	172..208	CDD:293791	22/35 (63%)
		WD40 repeat	212..257	CDD:293791	22/45 (49%)
Wipi2	NP_848485.1	WD40 repeat	18..53	CDD:293791	19/33 (58%)
		WD40 repeat	58..94	CDD:293791	19/35 (54%)
		WD40 repeat	102..134	CDD:293791	22/31 (71%)
		WD40	<118..342	CDD:441893	119/252 (47%)
		WD40 repeat	143..182	CDD:293791	15/38 (39%)
		WD 1. /evidence=ECO:0000255	182..222		25/39 (64%)
		WD40 repeat	188..228	CDD:293791	26/39 (67%)
		L/FRRG motif. /evidence=ECO:0000303|PubMed:24954904	223..226		2/2 (100%)
		WD 2. /evidence=ECO:0000255	228..267		24/63 (38%)
		WD40 repeat	233..266	CDD:293791	22/57 (39%)
		WD40 repeat	274..309	CDD:293791	16/34 (47%)
		WD 3. /evidence=ECO:0000255	311..349		18/37 (49%)