DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg18b and Wipi2

DIOPT Version :9

Sequence 1:	NP_001260667.1	Gene:	Atg18b / 35396	FlyBaseID:	FBgn0032935	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_848485.1	Gene:	Wipi2 / 74781	MGIID:	1923831	Length:	445	Species:	Mus musculus

Alignment Length:	383	Identity:	187/383 - (48%)
Similarity:	246/383 - (64%)	Gaps:	35/383 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NFNQDFTSLSVLSPTGLRLFSISSQDKVEEIFAKDNTEQIRIVERLFNSSLVVLVTAQKPNCLKM 71
            |||||.|||:|.|.:|.:.||:||.||:|:|:...:||.:.||||||:||||.:|:.:.|..||:
Mouse    19 NFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKV 83

  Fly    72 LHFKKKQDICNCFYPSEILCVRMNRQRLIVCLAESIHIHDIRDMKILHSIENIAPNEQGLCALSL 136
            .||||..:|||..|.:.||.|::|||||||||.||::||:|||||:||:|....||..||||||:
Mouse    84 CHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSI 148

  Fly   137 NS---HLAFPVCQTSGELRIFNASKLRTGMTIRAHDTSLSALAFSPSGALLATASERGTVIRVFC 198
            |:   :||:|...:.||:::|:...||....|.|||:.|:||||..||..||||||:|||||||.
Mouse   149 NNDNCYLAYPGSASIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFS 213

  Fly   199 VKNGQRVQEFRRGVS-CVRIASLVFSASGDFLCASSNTETVHVFKIDTRAVETVELKAIADVAAK 262
            :..||::.||||||. ||.|.||.||..|.||.|||||||||:||:
Mouse   214 IPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKL------------------- 259

  Fly   263 SENSAKEAVASTAAEESCRPVASWGGMFSKAV--SSLLLPTQVSEVLAQDRSFATVQLAQGGLKH 325
                  |||.....||.    .:|.|.|.|.:  |:..||:||:|:..|.|:||||:|...|.|:
Mouse   260 ------EAVREKPPEEP----TTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKN 314

  Fly   326 ICALTRVQKEPRLLIACEDGFLYVHEFPAERGGPCKLMSVHDLRGALEDVIELELSES 383
            ||:||.:||.||||:...||:||::....:.||.|.||..|.|.|::|...|:..|.|
Mouse   315 ICSLTTIQKIPRLLVGASDGYLYMYNLDPQEGGECALMRQHRLDGSMETTSEIVDSAS 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg18b	NP_001260667.1	WD40	<9..281	CDD:225201	140/275 (51%)
		WD40 repeat	79..122	CDD:293791	27/42 (64%)
		WD40	<89..242	CDD:295369	92/156 (59%)
		WD40 repeat	130..166	CDD:293791	15/38 (39%)
		WD40 repeat	172..208	CDD:293791	22/35 (63%)
		WD40 repeat	212..257	CDD:293791	22/45 (49%)
Wipi2	NP_848485.1	WD40 repeat	18..53	CDD:293791	19/33 (58%)
		WD40	<21..272	CDD:225201	140/279 (50%)
		WD40 repeat	58..94	CDD:293791	19/35 (54%)
		WD40 repeat	102..134	CDD:293791	22/31 (71%)
		WD40 repeat	143..182	CDD:293791	15/38 (39%)
		WD 1. /evidence=ECO:0000255	182..222		25/39 (64%)
		WD40 repeat	188..228	CDD:293791	26/39 (67%)
		FRRG motif. /evidence=ECO:0000303\|PubMed:24954904	223..226		2/2 (100%)
		WD 2. /evidence=ECO:0000255	228..267		24/63 (38%)
		WD40 repeat	233..266	CDD:293791	22/57 (39%)
		WD40 repeat	274..309	CDD:293791	16/34 (47%)
		WD 3. /evidence=ECO:0000255	311..349		18/37 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2110
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001466
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103112
Panther	1	1.100	-	-	O	PTHR11227
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1186
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.780