Protein Alignment Atg18b and WIPI1

DIOPT Version :9

• Sequence 1: NP_001260667.1
• Gene: Atg18b / 35396
• FlyBaseID: FBgn0032935
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_060453.3
• Gene: WIPI1 / 55062
• HGNCID: 25471
• Length: 446
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 192/473 - (40%)
• Similarity: 281/473 - (59%)
• Gaps: 71/473 - (15%)

  Fly     7 NFNQDFTSLSVLSPTGLRLFSISSQDKVEEIFAKDNTEQIRIVERLFNSSLVVLVTAQKPNCLKM 71
            :||||.|||:..:..|.:|||:||.::::::...:....:.||||||:|||||:|:..||..:.:
Human    21 SFNQDCTSLATGTKAGYKLFSLSSVEQLDQVHGSNEIPDVYIVERLFSSSLVVVVSHTKPRQMNV 85

  Fly    72 LHFKKKQDICNCFYPSEILCVRMNRQRLIVCLAESIHIHDIRDMKILHSIENIAPNEQGLCALSL 136
            .||||..:|||..|.|.||.:|:|||||:|||.|||:||:|:|||:|.::.:|..|..||||||:
Human    86 YHFKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTLLDIPANPTGLCALSI 150

  Fly   137 ---NSHLAFPVCQTSGELRIFNASKLRTGMTIRAHDTSLSALAFSPSGALLATASERGTVIRVFC 198
               ||:||:|...||||:.:::.:.|:|..||.||:.:|:|:.|:.||:.||:|||:|||||||.
Human   151 NHSNSYLAYPGSLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTVIRVFS 215

  Fly   199 VKNGQRVQEFRRGVS-CVRIASLVFSASGDFLCASSNTETVHVFKIDTRAVETVELKAIADVAAK 262
            |.:||::.|||||:. .|.|:|||||....||||||||||||:||:
Human   216 VPDGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKL------------------- 261

  Fly   263 SENSAKEAVASTAAEESCRPVASWGG----MFSKAVSSLLLPTQVSEVLAQDRSFATVQLAQGGL 323
                  |.|.::..||.    ::|.|    ||..|.:  .||||||:::.|||:|||.:|...|.
Human   262 ------EQVTNSRPEEP----STWSGYMGKMFMAATN--YLPTQVSDMMHQDRAFATARLNFSGQ 314

  Fly   324 KHICALTRVQKEPRLLIACEDGFLYVHEFPAERGGPCKLMSVHDLRGALEDVIELELSESVQRSQ 388
            ::||.|:.:||.||||:|...|.||::....:.||.|.|:..|.|.|:       ..:|..:.:.
Human   315 RNICTLSTIQKLPRLLVASSSGHLYMYNLDPQDGGECVLIKTHSLLGS-------GTTEENKEND 372

  Fly   389 TKPSNP----STVTQPSLTMLKSCAASVLIENPDPMQDNSYASILKGDQADAMSDSAKFRKLCDA 449
            .:||.|    :||.:||    .|.|::|    |...:|   ...|:|:    :....:|
Human   373 LRPSLPQSYAATVARPS----ASSASTV----PGYSED---GGALRGE----VIPEHEF------ 416

  Fly   450 IDTPTKLYDERQFPPVAI 467
            ...|..|.||.:|||:.:
Human   417 ATGPVCLDDENEFPPIIL 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg18b	NP_001260667.1	WD40	<9..281	CDD:225201	129/275 (47%)
		WD40 repeat	79..122	CDD:293791	26/42 (62%)
		WD40	<89..242	CDD:295369	88/156 (56%)
		WD40 repeat	130..166	CDD:293791	18/38 (47%)
		WD40 repeat	172..208	CDD:293791	20/35 (57%)
		WD40 repeat	212..257	CDD:293791	21/45 (47%)
WIPI1	NP_060453.3	WD 1	3..42		10/20 (50%)
		WD 2	47..88		14/40 (35%)
		WD40	<77..>262	CDD:225201	101/209 (48%)
		WD40	<88..262	CDD:295369	98/198 (49%)
		WD 3	92..126		21/33 (64%)
		WD 4	131..173		18/41 (44%)
		Nuclear receptor interaction	131..136		1/4 (25%)
		WD40 repeat	145..184	CDD:293791	18/38 (47%)
		WD 5	177..216		22/38 (58%)
		WD40 repeat	189..226	CDD:293791	21/36 (58%)
		WD 6	222..261		25/38 (66%)
		WD40 repeat	236..268	CDD:293791	21/56 (38%)
		WD40 repeat	274..312	CDD:293791	18/39 (46%)
		WD 7	304..343		18/38 (47%)
		WD40 repeat	320..358	CDD:293791	15/37 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..406		7/30 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2110
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	1	1.010	-	-		D1216824at2759
OrthoFinder	1	1.000	-	-		FOG0001466
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11227
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.890