DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg18b and wipi1

DIOPT Version :9

Sequence 1:	NP_001260667.1	Gene:	Atg18b / 35396	FlyBaseID:	FBgn0032935	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_956685.1	Gene:	wipi1 / 393362	ZFINID:	ZDB-GENE-040426-1404	Length:	453	Species:	Danio rerio

Alignment Length:	470	Identity:	194/470 - (41%)
Similarity:	268/470 - (57%)	Gaps:	65/470 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NFNQDFTSLSVLSPTGLRLFSISSQDKVEEIFAKDNTEQIRIVERLFNSSLVVLVTAQKPNCLKM 71
            :||||.|||:|.:.||.||||::|.||::.|.....|.::.||||||:|||||:|:...|..:.:
Zfish    23 SFNQDSTSLAVGTKTGYRLFSVTSVDKLDCIHESAETPEVYIVERLFSSSLVVVVSQSMPRRMNV 87

  Fly    72 LHFKKKQDICNCFYPSEILCVRMNRQRLIVCLAESIHIHDIRDMKILHSIENIAPNEQGLCALSL 136
            .||||..:|||..|.:.||.||:|||||:|||.|||:||:|:|||:|.::.|...|..||||||:
Zfish    88 YHFKKGTEICNYSYSNNILAVRLNRQRLVVCLEESIYIHNIKDMKLLKTLLNTPSNPSGLCALSI 152

  Fly   137 ---NSHLAFPVCQTSGELRIFNASKLRTGMTIRAHDTSLSALAFSPSGALLATASERGTVIRVFC 198
               ||.||:|...|.||:.:::|:.|.|...|.|||:.|:|:.||.||..||:|||||||||||.
Zfish   153 NHSNSFLAYPGSDTIGEIIVYDANNLSTVTMIPAHDSPLAAITFSASGTKLASASERGTVIRVFS 217

  Fly   199 VKNGQRVQEFRRGVS-CVRIASLVFSASGDFLCASSNTETVHVFKIDTRAVETVELKAIADVAAK 262
            :..|.|:.|||||:. .|.|:||.||....||||||||||||:||::..
Zfish   218 IPEGLRLFEFRRGMKRYVNISSLSFSPDAQFLCASSNTETVHIFKLEQH---------------- 266

  Fly   263 SENSAKEAVASTAAEESCRPVASW----GGMFSKAVSSLLLPTQVSEVLAQDRSFATVQLAQGGL 323
                      |.:.||.   ..||    |.||:.|  |..||.|||.:::|||:|.||:|...|.
Zfish   267 ----------SPSGEEE---APSWSAYVGKMFTAA--SSYLPAQVSGMMSQDRAFTTVRLQMAGQ 316

  Fly   324 KHICALTRVQKEPRLLIACEDGFLYVHEFPAERGGPCKLMSVHDLRGA---LEDVIELELSESVQ 385
            :::|||..:||.||||:|..||.|:::....:.||.|.|:..|.|.|:   .|:..:.:::|:.|
Zfish   317 RNVCALATIQKLPRLLVASSDGQLFIYNIDPQDGGECTLVQKHRLFGSDKEWEETNQSDMTEAPQ 381

  Fly   386 RSQTKPSNPSTVTQPSLTMLKSCAASVLIENPDPMQDNSYASILKGDQADAMSDSAKFRKLCDAI 450
            ..|                  |.||:|.|....|:     .:.|.|...|..:...:.....:..
Zfish   382 ACQ------------------SYAATVAIPTSGPV-----TATLTGYSEDGGAKKGEVIPEHEFA 423

  Fly   451 DTPTKLYDERQFPPV 465
            ..|..|.||.:|||:
Zfish   424 AGPVCLDDETEFPPI 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg18b	NP_001260667.1	WD40	<9..281	CDD:225201	133/275 (48%)
		WD40 repeat	79..122	CDD:293791	26/42 (62%)
		WD40	<89..242	CDD:295369	89/156 (57%)
		WD40 repeat	130..166	CDD:293791	17/38 (45%)
		WD40 repeat	172..208	CDD:293791	21/35 (60%)
		WD40 repeat	212..257	CDD:293791	20/45 (44%)
wipi1	NP_956685.1	WD40	<102..276	CDD:225201	94/202 (47%)
		WD40	<122..264	CDD:295369	78/141 (55%)
		WD40 repeat	147..186	CDD:293791	17/38 (45%)
		WD40 repeat	192..227	CDD:293791	20/34 (59%)
		WD40 repeat	237..269	CDD:293791	20/57 (35%)
		WD40 repeat	319..353	CDD:293791	15/33 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2110
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	1	1.010	-	-		D1216824at2759
OrthoFinder	1	1.000	-	-		FOG0001466
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11227
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.890