DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg18b and wdr45b

DIOPT Version :9

Sequence 1:	NP_001260667.1	Gene:	Atg18b / 35396	FlyBaseID:	FBgn0032935	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_956534.2	Gene:	wdr45b / 393210	ZFINID:	ZDB-GENE-040426-863	Length:	344	Species:	Danio rerio

Alignment Length:	368	Identity:	102/368 - (27%)
Similarity:	156/368 - (42%)	Gaps:	72/368 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FNQDFTSLSVLSPTGLRLFSISS-QDKVEEIFAKDNTEQIRIVERLFNSSLVVLVTAQK-----P 66
            ||||....:.....|.|:::... ::|.::.|.:..   :..||.||..:.:.||...|     |
Zfish    18 FNQDHGCFACGMENGFRVYNTDPLKEKEKQEFLEGG---VGHVEMLFRCNYLALVGGGKKPKYPP 79

  Fly    67 NCLKMLHFKKKQDICNCFYPSEILCVRMNRQRLIVCLAESIHI----HDIRDMKILHSIENIAPN 127
            |.:.:....||:.:....:.:|:..|::.|.|::|.|...|.:    |:...   ||..|. ..|
Zfish    80 NKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPHQ---LHVFET-CYN 140

  Fly   128 EQGLCAL---SLNSHLAFPVCQTSGELRIFN-ASKLRTGMTIRAHDTSLSALAFSPSGALLATAS 188
            .:|||.|   |.||.||||... ||.::|.: |:..:..:.|.||:..|..:..:..|..:||||
Zfish   141 PKGLCVLCPNSNNSLLAFPATH-SGHVQIVDLANTEKPPVDIPAHEGVLCCITLNLQGTRIATAS 204

  Fly   189 ERGTVIRVFCVKNGQRVQEFRRGVSCVRIASLVFSASGDFLCASSNTETVHVFKIDTRAVETVEL 253
            |:||:||:|....||.:||.|||.....|..:.|:.....:|.||:..|||:|
Zfish   205 EKGTLIRIFDTSAGQLIQELRRGSQTANIYCINFNQDASLICVSSDHGTVHIF------------ 257

  Fly   254 KAIADVAAKSENSAKEAVASTAAEESCRPVASWGGMFSKAVSSLLLPTQVSEVLAQDRSFATVQL 318
                                 |||:..|      ...|...|:..||    :..:...||:..|:
Zfish   258 ---------------------AAEDPKR------NKQSSLASASFLP----KYFSSKWSFSKFQV 291

  Fly   319 AQGGLKHICALTRVQKEPRLLIA-CEDGFLYVHEFPAERGGPC 360
            ..|. ..:||.   ..||..:|| |.||..|  :|.....|.|
Zfish   292 PSGS-PCVCAF---GTEPNAVIAICADGSYY--KFLFNPKGEC 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg18b	NP_001260667.1	WD40	<9..281	CDD:225201	79/285 (28%)
		WD40 repeat	79..122	CDD:293791	10/46 (22%)
		WD40	<89..242	CDD:295369	56/160 (35%)
		WD40 repeat	130..166	CDD:293791	15/39 (38%)
		WD40 repeat	172..208	CDD:293791	15/35 (43%)
		WD40 repeat	212..257	CDD:293791	9/44 (20%)
wdr45b	NP_956534.2	WD40	34..257	CDD:295369	71/230 (31%)
		WD40	80..>295	CDD:225201	72/262 (27%)
		WD40 repeat	102..126	CDD:293791	6/23 (26%)
		WD40 repeat	145..183	CDD:293791	14/38 (37%)
		WD 1	183..223		16/39 (41%)
		WD40 repeat	188..225	CDD:293791	16/36 (44%)
		WD 2	228..267		13/77 (17%)
		WD40 repeat	234..267	CDD:293791	12/71 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920