DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg18b and Wipi1

DIOPT Version :9

Sequence 1:	NP_001260667.1	Gene:	Atg18b / 35396	FlyBaseID:	FBgn0032935	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	XP_038942100.1	Gene:	Wipi1 / 303630	RGDID:	1307754	Length:	467	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	191/490 - (38%)
Similarity:	279/490 - (56%)	Gaps:	84/490 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NFNQDFTSLSVLSP---------------------TGLRLFSISSQDKVEEIFAKDNTEQIRIVE 50
            :||||.||:...:|                     ||.:|||:||.::::::...:....:.|||
  Rat    21 SFNQDCTSMRYTTPGPPTCPGMAPPTVGSLAIGTKTGYKLFSLSSVEQLDQVHGSNEIPDVYIVE 85

  Fly    51 RLFNSSLVVLVTAQKPNCLKMLHFKKKQDICNCFYPSEILCVRMNRQRLIVCLAESIHIHDIRDM 115
            |||:|||||:|:..||..:.:.||||..:|||..|.|.||.:|:|||||:|||.|||:||:|:||
  Rat    86 RLFSSSLVVVVSHTKPRQMNVYHFKKGTEICNYCYSSNILSIRLNRQRLLVCLEESIYIHNIKDM 150

  Fly   116 KILHSIENIAPNEQGLCALSL---NSHLAFPVCQTSGELRIFNASKLRTGMTIRAHDTSLSALAF 177
            |:|.::.:|..|..||||||:   ||:||:|..|::||:.:::.:.|:...||.||:.:|:|:.|
  Rat   151 KLLKTLLDIPSNPTGLCALSINHSNSYLAYPGSQSTGEIVLYDGNSLKMVCTIAAHEGTLAAITF 215

  Fly   178 SPSGALLATASERGTVIRVFCVKNGQRVQEFRRGVS-CVRIASLVFSASGDFLCASSNTETVHVF 241
            :.||:.||:|||:|||||||.|..||::.|||||:. .|.|:|||||....||||||||||||:|
  Rat   216 NSSGSKLASASEKGTVIRVFSVPEGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIF 280

  Fly   242 KIDTRAVETVELKAIADVAAKSENSAKEAVASTAAEESCRPVASWGGMFSKAVSSL--LLPTQVS 304
            |:                         |.:..:..||.    ::|.|...|.:::.  .||.|||
  Rat   281 KL-------------------------EQLTDSRPEEP----STWSGYMGKMLTAATNYLPAQVS 316

  Fly   305 EVLAQDRSFATVQLAQGGLKHICALTRVQKEPRLLIACEDGFLYVHEFPAERGGPCKLMSVHDL- 368
            :::.|||:|||.:|...|.|:||.|:.:||.||||:|..||.||::....:.||.|.|:..|.|
  Rat   317 DMMNQDRAFATGRLNFSGQKNICTLSTIQKLPRLLVASSDGHLYIYNLDPQDGGECVLIKTHSLL 381

  Fly   369 -RGALEDVIELELSESVQRSQTKPSNPSTVTQPSLTMLKSCAASVLIENPDPMQDNSYASILKGD 432
             .|..|:..|.:|     |....||..:||.:||    .|.|::|    |...:|   ...|:|:
  Rat   382 SSGTAEENKENDL-----RPSLPPSYAATVARPS----ASTASTV----PGYSED---GGALRGE 430

  Fly   433 QADAMSDSAKFRKLCDAIDTPTKLYDERQFPPVAI 467
                :....:|      ...|..|.||.:|||:.:
  Rat   431 ----VIPEHEF------ATGPVCLDDENEFPPIIL 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg18b	NP_001260667.1	WD40	<9..281	CDD:225201	127/296 (43%)
		WD40 repeat	79..122	CDD:293791	26/42 (62%)
		WD40	<89..242	CDD:295369	86/156 (55%)
		WD40 repeat	130..166	CDD:293791	16/38 (42%)
		WD40 repeat	172..208	CDD:293791	20/35 (57%)
		WD40 repeat	212..257	CDD:293791	21/45 (47%)
Wipi1	XP_038942100.1	WD40	<98..>365	CDD:225201	133/295 (45%)
		WD40 repeat	165..205	CDD:293791	17/39 (44%)
		WD40 repeat	210..247	CDD:293791	21/36 (58%)
		WD40 repeat	257..286	CDD:293791	20/53 (38%)
		WD40 repeat	293..333	CDD:293791	15/43 (35%)
		WD40 repeat	341..379	CDD:293791	16/37 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2110
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	1	1.010	-	-		D1216824at2759
OrthoFinder	1	1.000	-	-		FOG0001466
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11227
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1186
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.890