DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Atg18b and WIPI2

DIOPT Version :9

Sequence 1:NP_001260667.1 Gene:Atg18b / 35396 FlyBaseID:FBgn0032935 Length:471 Species:Drosophila melanogaster
Sequence 2:NP_056425.1 Gene:WIPI2 / 26100 HGNCID:32225 Length:454 Species:Homo sapiens


Alignment Length:396 Identity:185/396 - (46%)
Similarity:243/396 - (61%) Gaps:53/396 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 NFNQDFT------------------SLSVLSPTGLRLFSISSQDKVEEIFAKDNTEQIRIVERLF 53
            |||||.|                  ||:|.|.:|.:.||:||.||:|:|:...:||.:.||||||
Human    19 NFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLF 83

  Fly    54 NSSLVVLVTAQKPNCLKMLHFKKKQDICNCFYPSEILCVRMNRQRLIVCLAESIHIHDIRDMKIL 118
            :||||.:|:.:.|..||:.||||..:|||..|.:.||.|::|||||||||.||::||:|||||:|
Human    84 SSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVL 148

  Fly   119 HSIENIAPNEQGLCALSLNS---HLAFPVCQTSGELRIFNASKLRTGMTIRAHDTSLSALAFSPS 180
            |:|....||..||||||:|:   :||:|...|.||:::|:...||....|.|||:.|:||||..|
Human   149 HTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDAS 213

  Fly   181 GALLATASERGTVIRVFCVKNGQRVQEFRRGVS-CVRIASLVFSASGDFLCASSNTETVHVFKID 244
            |..||||||:|||||||.:..||::.||||||. ||.|.||.||..|.||.|||||||||:||::
Human   214 GTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLE 278

  Fly   245 TRAVETVELKAIADVAAKSENSAKEAVASTAAEESCRPVASWGGMFSKAV--SSLLLPTQVSEVL 307
            |                         |.....||.    .:|.|.|.|.:  |:..||:||:|:.
Human   279 T-------------------------VKEKPPEEP----TTWTGYFGKVLMASTSYLPSQVTEMF 314

  Fly   308 AQDRSFATVQLAQGGLKHICALTRVQKEPRLLIACEDGFLYVHEFPAERGGPCKLMSVHDLRGAL 372
            .|.|:||||:|...|.|:||:|..:||.||||:...||:||::....:.||.|.||..|.|.|:|
Human   315 NQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSL 379

  Fly   373 EDVIEL 378
            |...|:
Human   380 ETTNEI 385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atg18bNP_001260667.1 WD40 <9..281 CDD:225201 140/293 (48%)
WD40 repeat 79..122 CDD:293791 27/42 (64%)
WD40 <89..242 CDD:295369 93/156 (60%)
WD40 repeat 130..166 CDD:293791 16/38 (42%)
WD40 repeat 172..208 CDD:293791 22/35 (63%)
WD40 repeat 212..257 CDD:293791 23/45 (51%)
WIPI2NP_056425.1 WD 1. /evidence=ECO:0000255 15..60 13/40 (33%)
WD40 <37..290 CDD:225201 136/281 (48%)
WD 2. /evidence=ECO:0000255 67..104 17/36 (47%)
WD 3. /evidence=ECO:0000255 110..142 20/31 (65%)
WD40 <116..231 CDD:295369 65/114 (57%)
WD40 repeat 120..156 CDD:293791 23/35 (66%)
WD 4. /evidence=ECO:0000255 149..189 18/39 (46%)
WD40 repeat 161..200 CDD:293791 16/38 (42%)
WD40 <184..363 CDD:295369 92/207 (44%)
WD 5. /evidence=ECO:0000255 193..232 25/38 (66%)
WD40 repeat 206..246 CDD:293791 26/39 (67%)
WD 6. /evidence=ECO:0000255 238..277 26/38 (68%)
FRRG motif. /evidence=ECO:0000303|PubMed:24954904 241..244 2/2 (100%)
WD40 repeat 251..284 CDD:293791 21/57 (37%)
WD40 repeat 292..327 CDD:293791 16/34 (47%)
WD 7. /evidence=ECO:0000255 320..359 20/38 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2110
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54442
OrthoDB 1 1.010 - - D1216824at2759
OrthoFinder 1 1.000 - - FOG0001466
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_103112
Panther 1 1.100 - - O PTHR11227
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1186
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.790

Return to query results.
Submit another query.