DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg18b and mug179

DIOPT Version :9

Sequence 1:	NP_001260667.1	Gene:	Atg18b / 35396	FlyBaseID:	FBgn0032935	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_593843.1	Gene:	mug179 / 2543297	PomBaseID:	SPAC823.16c	Length:	335	Species:	Schizosaccharomyces pombe

Alignment Length:	362	Identity:	93/362 - (25%)
Similarity:	164/362 - (45%)	Gaps:	47/362 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NFNQDFTSLSVLSPTGLRLFSISSQDKVEEIFAKDNTEQIRIVERLFNSSLV--VLVTAQKPNCL 69
            ::|||...||:.|..|   :.:...:.....|:| ......|.|.|:.|||:  |.::.:....|
pombe     9 SWNQDRGFLSIGSENG---YQVYRSNPFTLCFSK-KANGASICEMLYESSLLAFVNISPESTRLL 69

  Fly    70 KMLHFKKKQDICNCFYPSEILCVRMNRQRLIVCLAESIHIHDIRDMKILHSIENIAPNEQGLCAL 134
            |::..|:...:|..||||.:|.||....||:|.:..||:::::::|::::::.....|   :.|.
pombe    70 KLVDIKRDIVLCRIFYPSPVLSVRFTWNRLVVLIKGSIYVYNLKNMELINTLNTSKGN---VIAF 131

  Fly   135 SLN-SHLAFPVCQTSGELRIFNASKLRTGMTIRAHDTSLSALAFSPSGALLATASERGTVIRVFC 198
            ::: :::|:......|::.:.:.........|..|.:::..:.|.|.|.|:||||.:||||||..
pombe   132 AVHENYVAYNSPTNPGDIYLASLDTAIPVTLIHCHSSAVQVVDFHPRGHLIATASAKGTVIRVIT 196

  Fly   199 VKNGQRVQEFRRGVSCVRIASLVFSASGDFLCASSNTETVHVFKIDTRAVETVELKAIADVAAKS 263
            ..:|:.|.|.|||.....|.|:.|.....||..:|...|:|||||                 :|.
pombe   197 TSDGELVTELRRGYIPASIVSISFHPVEPFLACASENGTIHVFKI-----------------SKQ 244

  Fly   264 ENSAKEAVASTAAEESCRPVASWGGMFSKAVSSLLLPTQVSEVLAQDRSFATVQLAQGGL--KHI 326
            .:....:..|:....|     ||         |..|.:.|::|....:.|||.::.:...  |.|
pombe   245 PSDPNSSPTSSVTVSS-----SW---------SKYLTSNVAKVWDTRKEFATAKIPEASFYGKII 295

  Fly   327 CALTRVQKEPRLLIACEDGFLYVHEFPAERGGPCKLM 363
            .:    ...|.:.:|...|..|......:.||.|.|:
pombe   296 FS----SSGPHIQVASYSGHYYRFAVNLKNGGNCALL 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg18b	NP_001260667.1	WD40	<9..281	CDD:225201	74/274 (27%)
		WD40 repeat	79..122	CDD:293791	14/42 (33%)
		WD40	<89..242	CDD:295369	44/153 (29%)
		WD40 repeat	130..166	CDD:293791	3/36 (8%)
		WD40 repeat	172..208	CDD:293791	16/35 (46%)
		WD40 repeat	212..257	CDD:293791	12/44 (27%)
mug179	NP_593843.1	WD40 repeat	8..43	CDD:293791	9/37 (24%)
		WD40 repeat	47..86	CDD:293791	11/38 (29%)
		WD40	<64..>315	CDD:225201	73/288 (25%)
		WD40	<87..240	CDD:295369	45/155 (29%)
		WD40 repeat	89..123	CDD:293791	9/33 (27%)
		WD40 repeat	127..165	CDD:293791	5/40 (13%)
		WD40 repeat	170..208	CDD:293791	17/37 (46%)
		WD40 repeat	216..246	CDD:293791	12/46 (26%)
		WD40 repeat	253..284	CDD:293791	11/44 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	146	1.000	Domainoid score	I1135
eggNOG	1	0.900	-	-		E1_KOG2110
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoFinder	1	1.000	-	-		FOG0001466
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103112
Panther	1	1.100	-	-	O	PTHR11227
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1186
TreeFam	0	0.000	Not matched by this tool.
	8	7.820