Protein Alignment CG8679 and ANKRD20A1

DIOPT Version :10

• Sequence 1: NP_610099.1
• Gene: CG8679 / 35395
• FlyBaseID: FBgn0032934
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_115626.2
• Gene: ANKRD20A1 / 84210
• HGNCID: 23665
• Length: 823
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 124/636 - (19%)
• Similarity: 231/636 - (36%)
• Gaps: 180/636 - (28%)

  Fly    63 LERFLECPDLDVNALCDGQTTALHIASIYGRTELVRMLLERGACADLADEDNKLP---------- 117
            :||.|.....|::||.....||||:|...|..::|.:|:.|....|:.|::|:.|
Human    49 VERCLARRSGDLDALDKQHRTALHLACTSGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEE 113

  Fly   118 -----------------------VHYAI-------------EECHFEVLQLLRDH----IF---- 138
                                   :|||:             ...|.|.|.  :|:    :|
Human   114 ACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALD--KDNNTPLLFAIIC 176

  Fly   139 -RERQIQ--KKQQQRVQVVDALTPNQPRYNHDVTSPYYINITHRRHRPQPKFPEPTEVECADIPP 200
             :|:.::  .|::.....||.|..:.........||..:||..:::         .:|...|:..
Human   177 KKEKMVEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQN---------IDVFAQDMCG 232

  Fly   201 LPDEESVNLFALTEAHLTQLIQSQRQNQPEDPCQPKRRTLIESWREKVERSRARQSLFHQYDEHV 265
            ...|:    :|::. |||::.|...::        |::.|.:...:......:..|:||
Human   233 RDAED----YAISH-HLTKIQQQILEH--------KKKILKKEKSDVGSSDESAVSIFH------ 278

  Fly   266 EAMVDD--AISQEDFNY--KEHLQKKLRDEDNSKNLTEDAPNSGRQVFEMLVEQVSQAVVVEPEP 326
            |..||.  |...:|.|.  |:.:.:|         ::|..|.|..:....:|....:.    |..
Human   279 ELRVDSLPASDDKDLNVATKQCVPEK---------VSEPLPGSSHEKGNRIVNGQGEG----PPA 330

  Fly   327 EHSFFTAQGDEVDVAESSA--RQDEYFLQIKEAYVHTDDENGLVFYEARYLQNRDRREPVEQ--- 386
            :|.......:..|.|...|  |::...|:.::|.....:|.     :.|:.::..::..|::
Human   331 KHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEE-----QERHERSEKKQPQVKEGNN 390

  Fly   387 TPKERKHDLESSVSTNYTLPLDYETDALRRELTQLGAPVGPITKTTKRLYIKQL----------- 440
            |.|..|..|..::       .|..:.|....|||    ...|.||..:.:.|:|
Human   391 TNKSEKIQLSENI-------CDSTSSAAAGRLTQ----QRKIGKTYPQQFPKKLKEEHDRCTLKQ 444

  Fly   441 ---------IKYKRNTEALLAAQKHAQDAQIRYSVE---LHRTLRSPEDFARIN------DYLPH 487
                     :.||:|.|.|...:|     |.:..||   |..|::|.|..::..      |:..|
Human   445 ENEEKTNVNMLYKKNREELERKEK-----QYKKEVEAKQLEPTVQSLEMKSKTARNTPNWDFHNH 504

  Fly   488 EATSAAHFAQCGVTKKNMREGHLKQSFIYMLIDPRISRNLPGESAFLEKFGVWQR---FLDSIFY 549
            |.........| :.|.::  ..|:|....|..|     ||..|:.:|:...:.:.   .|:....
Human   505 EEMKGLMDENC-ILKADI--AILRQEICTMKND-----NLEKENKYLKDIKIVKETNAALEKYIK 561

  Fly   550 IGKGKCS----RPYAHLYDAMRQHTRLHQKREKDKTNRERGGGFRTLQPDV 596
            :.:...:    |....|.|...::|||:.:..|:|.:::|      |:.|:
Human   562 LNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKR------LEADI 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8679	NP_610099.1	ANKYR	<11..>136	CDD:440430	25/118 (21%)
		ANK repeat	42..78	CDD:293786	5/14 (36%)
		ANK repeat	80..111	CDD:293786	10/30 (33%)
		LEM	404..447	CDD:128813	12/62 (19%)
		GIY-YIG_COG3680_Meta	513..657	CDD:198401	18/91 (20%)
ANKRD20A1	NP_115626.2	ANKYR	31..247	CDD:440430	43/213 (20%)
		ANK repeat	37..64	CDD:293786	5/14 (36%)
		ANK 1	66..95		9/28 (32%)
		ANK repeat	68..97	CDD:293786	10/28 (36%)
		ANK repeat	99..130	CDD:293786	2/30 (7%)
		ANK 2	99..128		2/28 (7%)
		ANK repeat	132..163	CDD:293786	5/30 (17%)
		ANK 3	132..161		4/28 (14%)
		ANK repeat	165..196	CDD:293786	4/30 (13%)
		ANK 4	165..194		4/28 (14%)
		ANK repeat	198..229	CDD:293786	6/39 (15%)
		ANK 5	198..227		6/37 (16%)
		Mitofilin	271..694	CDD:430783	78/390 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..343		7/54 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..402		9/51 (18%)
		CCDC144C	514..805	CDD:464371	22/107 (21%)