DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8679 and ANKRD18B

DIOPT Version :10

Sequence 1:NP_610099.1 Gene:CG8679 / 35395 FlyBaseID:FBgn0032934 Length:704 Species:Drosophila melanogaster
Sequence 2:NP_001340361.1 Gene:ANKRD18B / 441459 HGNCID:23644 Length:1181 Species:Homo sapiens


Alignment Length:669 Identity:125/669 - (18%)
Similarity:242/669 - (36%) Gaps:165/669 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 IMSMLERNSINAGIVPCDRGLAPLHYVCGMRNGGLAQRILERFLECPDLDVNALCDGQTTALHIA 88
            ::|.:::.....|....|..|..:|......:....:..|.|...  ||||....|  .|.||:|
Human    15 LLSSMDQEYAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFR--DLDVRDRKD--RTVLHLA 75

  Fly    89 SIYGRTELVRMLLERGACADLADEDNKLP----VHYAIEEC----------------------HF 127
            ..:||.::|.:||:|....::.|..|:.|    ||...|.|                      |:
Human    76 CAHGRVQVVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHY 140

  Fly   128 EVL--------QLLRDHIFRERQIQKK---------QQQRVQVVDALTPNQPRYN---------- 165
            .|.        :||..|...| .:.|:         ..:|..:|:.|..||...:          
Human   141 AVYNEGTSLAERLLSHHANIE-ALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTAL 204

  Fly   166 -----HDVTSPYYINITHRRH-RPQPKFPEPTE--VECADIPPLPDEESVNLFALTEAHLTQLIQ 222
                 |:::|...:.:....| ..|..|.:..|  ..|.|:..:..:...:...:.:.||....|
Human   205 ILAVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQ 269

  Fly   223 SQRQNQPEDPCQPKRRTLI----------------ESWREKVERSRARQ------------SLFH 259
            .....:||:..:.|:|..:                |..:|::|||..:|            .:|.
Human   270 ETAAMKPENLKKRKKRKKLKKRKEGAKEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFG 334

  Fly   260 QY---------DEHVEAMVDDAISQEDFNYKEHLQKKLRDEDNSKNLTEDAPNSGRQV---FEML 312
            .:         .|.:.|:.:|::.:|    |:::|:       .|::||...|..:.|   .||:
Human   335 NFMLKRDIAMLKEELYAIKNDSLRKE----KKYIQE-------IKSITEINANFEKSVRLNEEMI 388

  Fly   313 VEQVSQAVVVEPEPEHSFFTAQGDEVDVAESSARQDEYFLQIKEAYVHTDDENGLVFYEARYLQN 377
            .::|:|.     ..:.:...|:...::......:.::..|:.:...:|::....:..|. ..|:.
Human   389 TKKVAQY-----SQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAINEYN-EILER 447

  Fly   378 RDRREPVEQTPKERKHDLESSVSTNYTLPLDYETDALRRELTQLGAPVGPITKTTKRLYIKQLIK 442
            :|....:.:.....:|:...|..:..|...:..|:.:.:...:.....|.:.:|...|       
Human   448 KDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDAL------- 505

  Fly   443 YKRNTEALLAAQKHAQDAQ--IRYSVELHRTLRSPEDFARINDYLPHEATSAAHFAQCGVTKKNM 505
             :..|.||.:.|...:.||  |:...::|     |...|:       |:.|        :.|:|.
Human   506 -REKTLALESVQLDLKQAQHRIKEMKQMH-----PNGEAK-------ESQS--------IGKQNS 549

  Fly   506 REGHLKQSFIYMLIDPRISRNLPGESAFLEKFGVWQRFLDSIF--YIGKGKCSRPYAHLYDAMRQ 568
            .|..::|..:..|:   :.|.|  |.|  .|.|..:..:.:|.  .:..||.........:.|.:
Human   550 SEERIRQRELENLL---LERQL--EDA--RKEGDNKEIVINIHRDCLENGKEDLLEERNKELMNE 607

  Fly   569 HTRLHQK---REKDKTNRE 584
            :..|.:|   .||:|..||
Human   608 YNYLKEKLLQYEKEKAERE 626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8679NP_610099.1 ANKYR <11..>136 CDD:440430 33/145 (23%)
ANK repeat 42..78 CDD:293786 8/35 (23%)
ANK repeat 80..111 CDD:293786 10/30 (33%)
LEM 404..447 CDD:128813 5/42 (12%)
GIY-YIG_COG3680_Meta 513..657 CDD:198401 18/77 (23%)
ANKRD18BNP_001340361.1 ANK repeat 38..65 CDD:293786 7/28 (25%)
ANKYR 39..268 CDD:440430 47/233 (20%)
ANK repeat 69..98 CDD:293786 10/28 (36%)
ANK repeat 100..131 CDD:293786 6/30 (20%)
ANK repeat 133..164 CDD:293786 6/31 (19%)
ANK repeat 166..197 CDD:293786 5/30 (17%)
ANK repeat 199..230 CDD:293786 3/30 (10%)
CCDC144C 335..625 CDD:464371 60/341 (18%)
SMC_N <468..865 CDD:481474 40/194 (21%)
DUF3496 871..977 CDD:463425
Blue background indicates that the domain is not in the aligned region.

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