DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8679 and Ankle1

DIOPT Version :9

Sequence 1:	NP_610099.1	Gene:	CG8679 / 35395	FlyBaseID:	FBgn0032934	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_006253021.1	Gene:	Ankle1 / 361122	RGDID:	1308184	Length:	512	Species:	Rattus norvegicus

Alignment Length:	732	Identity:	180/732 - (24%)
Similarity:	274/732 - (37%)	Gaps:	260/732 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ANFLALTLLDALEDENEADIMSMLERNSINAGIVPCDRGLAPLHYVCGMRNGGLAQRILE-RFLE 68
            |:.|:|.||.||.:| ||..:..|.|...:..:| .|.|.|.:|         ||.|... |.|.
  Rat     4 ASSLSLQLLAALREE-EARAVEKLLRLGADPNLV-LDDGAAAVH---------LAARASHPRALH 57

  Fly    69 CPDL------DVNALCDGQTTALHIASIYGRTELVRMLLERGACADLADEDNKLPVHYAIEECHF 127
            |..:      |.||......|.:|:|:.:|....:.:||.||....|.|:|...|:.:|:::.|.
  Rat    58 CLRMLLRWGADPNARSAEALTPVHVAAAWGCCSALELLLSRGGDPTLRDQDGLRPLDWALQQQHH 122

  Fly   128 EVLQLLRDHIFRERQIQKKQQQRVQVVDALT--PNQPRYNHDVTSPYYINITHRRHRPQPKFPEP 190
            ...::||:                  :|..|  ||:                    .|:|....|
  Rat   123 NCARVLRE------------------LDTPTRKPNE--------------------TPKPTAGSP 149

  Fly   191 --------------TEVECADI---PPLPDEESVNLFALTEAHLTQLIQSQRQNQPEDPCQPKR- 237
                          .|||..::   |..|:....:.::...:.:|.:         ||..||:|
  Rat   150 GASQDSELHMHRAELEVEAVEVAVQPQSPEATESSDYSSDASFVTAV---------EDSLQPRRP 205

  Fly   238 ----RTLIESWREKVERSRARQSLFHQYDEHVEAMVDDAISQEDFNYKEHLQKKLRDEDNSKNLT 298
                ..:...|   |.|..|                                          :..
  Rat   206 GGICELMASLW---VTRGAA------------------------------------------SAG 225

  Fly   299 EDAPNSGRQVFEMLVEQVSQAVVVEPEPEHSFFTAQGDEVDVAESSARQDEYFLQIKEAYVHTDD 363
            |.|||...|..          .:.|...:.......||                 :...:.|
  Rat   226 EGAPNCQSQAL----------TLTEKSTDKPLLLGDGD-----------------LGALHPH--- 260

  Fly   364 ENGLVFYEARYLQNRDRREPVEQTPKERKHDLESSVSTNYTLPLDYETDALRRELTQLGAPVGPI 428
              |.|             .|:.        ||:                 |.:.|..||...||:
  Rat   261 --GSV-------------PPMS--------DLQ-----------------LLQALRALGYSPGPV 285

  Fly   429 TKTTKRLYIKQLIKYKRNTEALLAAQKHAQDAQIR--YSVELHRTLRSPEDFARINDYLPHEATS 491
            |..|:..|:::|                 |:||..  :|.||...||:    ..:.|....||..
  Rat   286 TPFTRGHYLRRL-----------------QEAQASPGHSPELAEALRT----GTVPDCQVDEAAL 329

  Fly   492 AAHFAQCGVTKKNMREGHLKQSFIYMLIDPRISRNLPGESAFLEKFGVWQRFLDSIFYIGKGKCS 556
            |.||.:...::| .|||..|.||.|:|:|||::::||..::.|......|.|:.:|||:|||..:
  Rat   330 AQHFQRPDPSRK-WREGITKSSFTYLLLDPRLTKDLPARASSLTLAQCLQCFVRAIFYVGKGTRA 393

  Fly   557 RPYAHLYDAMRQHTRLHQKREKDKTNRERGGGFRTLQPDVFRSPPPGDGKMGSRKLERILDIWQH 621
            ||.|||::|...|.                      ||          .|....|:.||||||..
  Rat   394 RPDAHLWEARGYHD----------------------QP----------RKQVCPKIRRILDIWDS 426

  Fly   622 GSGVVCLHVFHNILPIDAYTREASIIDALGLNHLTNIKRGDYYGPAQSWTMKQKKQLGIALLFKA 686
            |.|::.||.|.:::.::||||||.::|||||..|||.|:|.|||....|.:.::::||:.||.:|
  Rat   427 GRGIISLHCFQHVVAVEAYTREACLLDALGLQTLTNQKQGHYYGVVAHWPLPRRRRLGVYLLQRA 491

  Fly   687 MHIYLAEGESQLSPSDL 703
            :.::|||||.:|.|.|:
  Rat   492 LLVFLAEGERELRPQDI 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8679	NP_610099.1	ANK	15..133	CDD:238125	35/124 (28%)
		ANK repeat	42..78	CDD:293786	12/42 (29%)
		Ank_5	67..121	CDD:290568	17/59 (29%)
		ANK repeat	80..111	CDD:293786	9/30 (30%)
		LEM	404..447	CDD:128813	10/42 (24%)
		GIY-YIG_COG3680_Meta	513..657	CDD:198401	52/143 (36%)
Ankle1	XP_006253021.1	Ank_2	22..106	CDD:289560	25/93 (27%)
		ANK	23..128	CDD:238125	30/114 (26%)
		ANK repeat	75..106	CDD:293786	9/30 (30%)
		Ank_4	77..128	CDD:290365	14/50 (28%)
		LEM	266..303	CDD:295412	15/78 (19%)
		GIY-YIG_COG3680_Meta	350..462	CDD:198401	52/143 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	154	1.000	Domainoid score	I4173
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3589
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1451150at2759
OrthoFinder	1	1.000	-	-		FOG0005201
OrthoInspector	1	1.000	-	-		oto95453
orthoMCL	1	0.900	-	-		OOG6_107773
Panther	1	1.100	-	-	LDO	PTHR46427
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4821
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.970