Protein Alignment CG8679 and lem-3

DIOPT Version :10

• Sequence 1: NP_610099.1
• Gene: CG8679 / 35395
• FlyBaseID: FBgn0032934
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_492539.2
• Gene: lem-3 / 172792
• WormBaseID: WBGene00002276
• Length: 704
• Species: Caenorhabditis elegans
• Alignment Length: 743
• Identity: 170/743 - (22%)
• Similarity: 274/743 - (36%)
• Gaps: 218/743 - (29%)

  Fly    85 LHIASIYGRT---ELVRMLLERGACADLADEDNKLPVHYAIEECHFEVLQLL---------RDHI 137
            ||..:....|   :..|.||||||..:..|.|...|:|||....:..:.|||         .|.:
 Worm    32 LHYLAASSSTTSVDAARTLLERGANVNAIDRDGATPLHYACTHDNVAMAQLLLTFGADPMSADKL 96

  Fly   138 --------------FRERQIQKKQQQRV----------------------QVVDALTPN------ 160
                          |..|..:...:||:                      |.|..|.|.
 Worm    97 GRTAYSIAKGNTLRFLRRYKKSSNRQRLGFFRRFFACHSRNETFFIVRNNQEVAPLRPTALAEAA 161

  Fly   161 QPRYNHD--VTSPY-----YINITH---RRHR----------------------PQPKFPEPT-- 191
            ...:|..  :|:.|     .|..|.   ||.|                      |..:.|:.|
 Worm   162 SISFNRGNVLTNSYRCAKKKIRATFHAIRRSRSNSTATLQDVVLTSEGIRTVTTPSRRAPKATVY 226

  Fly   192 ---EVECADIPPLPDEESV-NLFALTEAHLTQLIQ-SQRQNQPEDPCQP-KRRTLIESWREKVER 250
               .:..:|:..:||...: |....|.....:..: :.|...||....| |:||.:...:    |
 Worm   227 AKRSMSVSDLLLIPDRRDIKNEDVKTRGSPVKKTRGTGRSRTPEAILNPRKQRTPVNHHK----R 287

  Fly   251 SRARQSLFHQYDEHVEAMVDDAISQEDFNYKEHLQKKLRDEDNSKNLTEDAPNSGRQVFEMLVEQ 315
            |:::::..        ..:....|...:|........||...::..|:.:.
 Worm   288 SKSQETKL--------VAMPSPNSMAYYNTSRARNAGLRPAPSAPPLSPEP-------------- 330

  Fly   316 VSQAVVVEPEPEHSFFTAQGDEVDVAESSARQDEYFLQIKEAYVHTDDE------NGLVFYEARY 374
             :.|.|..|:...:..|::|.    ::|.|....||         |.||      |.:   |...
 Worm   331 -AIAAVKTPKTPTTPKTSKGR----SKSPANTTAYF---------TADESLELLGNNM---EKLN 378

  Fly   375 LQNRDRREPVEQTPKE-----------RKHDLESSVSTNYTLPLDYETDALRR--------ELTQ 420
            ::::..:....:||.:           .:.|.|:.|||..|:. |.|...:||        ||.:
 Worm   379 IESKSAKSSKLKTPSKPTTSSSTSFSSAEDDKEAEVSTPTTVD-DGEIRKIRRLREGELKSELKK 442

  Fly   421 LG-APVGPITKTTKRLYIKQLIKYKRNTEALLAAQKHAQDAQI---RYSVELHRTLRSPEDFARI 481
            .| :|.||:...|:|||.|:|:..:|.    :..:.::.||.:   |.|.:|...||
 Worm   443 FGISPAGPLDARTRRLYEKKLLIERRK----ITNRGYSPDADVVSCRNSPQLELVLR-------- 495

  Fly   482 NDYLPHEATSAAHFAQCGVTKKNMREGHLKQSFIYMLIDPRI-SRNLPGESAFLEKFGVWQRFLD 545
            |.:||.:..|.|......|..:....|....:|.|:::|||| ..|:  |:..||      .|:.
 Worm   496 NGFLPADFASRARKCDENVRSEFSGNGFGYNAFCYLIMDPRILGSNV--ENLTLE------TFVR 552

  Fly   546 SIFYIGKGKCSRPYAHLYDAMRQHTRLHQKREKDKTNRERGGGFRTLQPDVFRSPPPGDGKMGSR 610
            ||||:|||..:||.||..||..:.   ..|.:|.||                           ..
 Worm   553 SIFYVGKGSKNRPLAHFIDARNER---RDKLDKLKT---------------------------CE 587

  Fly   611 KLERILDIWQHGSGVVCLHVFHNILPIDAYTREASIIDALGLNHLTNIKRGDYYGPAQSWTMKQK 675
            ||:.|.::|..|.|:....:.|.:...:|:.||||||:|:.|.:|.|.|.|:::|..:||....|
 Worm   588 KLKTIDELWTLGFGIPRHEISHGVSDEEAFVREASIIEAVKLKNLRNKKAGEFHGTTKSWDNITK 652

  Fly   676 KQLGIALLFKAMHIYLAEGESQLSPSDL 703
            .:.|..||.:|:.....||...::..:|
 Worm   653 SEYGTFLLDRALSTLKLEGIRLITEDNL 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8679	NP_610099.1	ANKYR	<11..>136	CDD:440430	19/62 (31%)
		ANK repeat	42..78	CDD:293786
		ANK repeat	80..111	CDD:293786	10/28 (36%)
		LEM	404..447	CDD:128813	18/51 (35%)
		GIY-YIG_COG3680_Meta	513..657	CDD:198401	45/144 (31%)
lem-3	NP_492539.2	ANKYR	<30..>107	CDD:440430	20/74 (27%)
		ANK repeat	32..61	CDD:293786	10/28 (36%)
		ANK repeat	63..94	CDD:293786	8/30 (27%)
		ANK repeat	96..122	CDD:293786	2/25 (8%)
		LEM	426..470	CDD:128813	15/47 (32%)
		GIY-YIG_COG3680_Meta	527..634	CDD:198401	45/144 (31%)