DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Ir75b

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster

Alignment Length:	716	Identity:	145/716 - (20%)
Similarity:	240/716 - (33%)	Gaps:	213/716 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 KLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITTVRLMD 267
            |||  :.|||||:          .:.|.:|.:.:::|......||              .::|.|
  Fly    17 KLS--HVLILHCS----------LSHLALLAQSKNIFTQFQPLHS--------------DIQLND 55

  Fly   268 PSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEEL------T 326
              ||...|::                                        :||:|.::      |
  Fly    56 --DFLNHNIL----------------------------------------KLGVFLDINCDKSGT 78

  Fly   327 APDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDP 391
            ..|:...::.   |..|....|..||...|.....|.|           .::..|..:...|.||
  Fly    79 VLDMASAKRF---FSHRYHWLIYDRSMNFSVLESHFKE-----------AQIFVDADVTYVTHDP 129

  Fly   392 VNGLDVLNDDEESEKRVGQKLS---------NKTFIVSSRLGAPFLTLREPQEGEILTG------ 441
            .:...:|.|.....:::|.:|:         |||.....|..:...|....|..:..||
  Fly   130 FSKNFLLYDVYNKGRQLGGELNITADREIFCNKTNCRVERYLSELYTRSALQHRKSFTGLTMRAT 194

  Fly   442 -------------------NSRYE---------GYSIDLINEIAKMLNFKFEF----RMSPDGKY 474
                               ||:|.         ||...  ..:..||:.||::    |.|.....
  Fly   195 AVVTALPLNVSIKEIFDFMNSKYRIQLDTYARLGYQAR--QPLRDMLDCKFKYIFRDRWSDGNAT 257

  Fly   475 GALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLF 539
            |          |::..||...|||.|.....:..|...:.....|.......:|..|.:....|.
  Fly   258 G----------GMIGDLILDKADLAIAPFIYSFDRALFLQPITKFSVFREICMFRNPRSVSAGLS 312

  Fly   540 S--FLSPFSLDVWIYMGSAYLFISLLL---FALARMAPDDWENPHPCKEPEEVENIWSIMNTTWL 599
            :  ||.|||..||:......|....||   |.|.|.  ..|:.              |::.:..|
  Fly   313 ATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERR--KQWKP--------------SLLTSCLL 361

  Fly   600 SIGSLMGQGCDILPKAASTRLVTGMWWFFALM-----MLNSYTANLAAFLTNSRQANSINSAEDL 659
            |.|:...||..:.|::...|:.     |||||     |.|.||:.:.:.|......::|.:.:.|
  Fly   362 SFGAGCIQGAWLTPRSMGGRMA-----FFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQL 421

  Fly   660 AAQSKIKYGAMAGGSTMGFFRDS---------------NFSTYQKMWTAMESASPSVFTKTNDEG 709
             |.|.:..|......|..:...|               :..:..|:|...|:   .|.:..:.||
  Fly   422 -ADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEA---GVLSVRDQEG 482

  Fly   710 VERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGE 774
            ...:......|.|:.:    .:...:.|:|.:| ...|.......:...|||.:.|..:.|::.|
  Fly   483 FVYITGVATGYEFVRK----HFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELRMLE 542

  Fly   775 LGQLAELKRKWWK-EMHGGGNCEKSDEDGGDTPELGLENVGGVFLV-LGLGLLSAMVLGCTEFLW 837
            .|...:.:|.|.: ::|    |.:.:.    |..:|||....:|:: ||..:|...:|| .|.:|
  Fly   543 TGVHFKHERSWMETKLH----CYQHNH----TVAVGLEYAAPLFIILLGAIILCMGILG-LEVIW 598

  Fly   838 N 838
            :
  Fly   599 H 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	35/198 (18%)
		ANF_receptor	39..379	CDD:279440	31/181 (17%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	92/435 (21%)
		Lig_chan	548..812	CDD:278489	60/287 (21%)
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	72/339 (21%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	59/279 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462590
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740