DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and GLR2.5

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001332219.1	Gene:	GLR2.5 / 830991	AraportID:	AT5G11210	Length:	918	Species:	Arabidopsis thaliana

Alignment Length:	934	Identity:	194/934 - (20%)
Similarity:	340/934 - (36%)	Gaps:	218/934 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYSLFLTHFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYA 65
            :.|.||:.:|||.|         .|:|.|:..|.|:..::  :..:    :|..||.|..:.:.|
plant     7 LVSRFLSLWLLIFL---------VFLVLSLGKSQKEALQV--KVGI----VLGSNVTLADLSLRA 56

  Fly    66 ---------NTDDSFIMEKMVCN------------------LISQGVIAIFGPSTGSSSDIIASI 103
                     ||.:.| ..::|.|                  :..:.|:||.||.|...:..:.::
plant    57 INMSLSEFYNTHNGF-KTRIVLNVRDSKQTVVGAAASALYLIKKREVVAIIGPGTSMQAPFLINL 120

  Fly   104 CDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKE-- 166
            .:...:|.|.:.  ....:.|...|...:....|:....|.::.|::||.||....:| .|.|
plant   121 GNQSKVPIISFS--ATSPLLDSLRSPYFIRATHDDSSQVQAISAIIESFRWREVVPIY-VDNEFG 182

  Fly   167 ---LQQLQDILQ-VGEPISNPTTVKQLGPGDDHRPFLKEI-KLST--DNCLILHCAPDNLLKILQ 224
               |..|.|..| :...|...:.: .|...||.  ..||: ||.|  ....|:|..||...::..
plant   183 EGILPNLVDAFQEINVRIRYRSAI-SLHYSDDQ--IKKELYKLMTMPTRVFIVHMLPDLGSRLFS 244

  Fly   225 QANELKML--GEYQSVFIPLLDTHSIDFGELSGVEAN-ITTVRLMDPSDFHVKNVVHDWEEREKR 286
            .|.|:.||  |....|...:.|..|| .||.|.|..: :..|:........:.::...|::|...
plant   245 IAKEIDMLSKGYVWIVTNGIADLMSI-MGESSLVNMHGVLGVKTYFAKSKELLHLEARWQKRFGG 308

  Fly   287 EGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKAR 351
            |.               |.|.|.|.:..........||:...::.....|
plant   309 EE---------------LNNFACWAYDAATALAMSVEEIRHVNMSFNTTK--------------- 343

  Fly   352 SEETSTGRI--DFNE-----NGQRSFFTL----------RFMELNSDGFLDLATWDPVNGLDVLN 399
             |:||...|  |.:|     :|.:....|          ||...|  |.|:..|:      .::|
plant   344 -EDTSRDDIGTDLDELGVALSGPKLLDALSTVSFKGVAGRFQLKN--GKLEATTF------KIIN 399

  Fly   400 DDEESEKRVG--------------QKLSNKTFIVSSRLGAPFL----TLREPQEGEILTGNSRYE 446
            .:|..|:.||              .|:|:     |||...|.:    |:..|:..|..|...:..
plant   400 IEESGERTVGFWKSKVGLVKSLRVDKVSH-----SSRRLRPIIWPGDTIFVPKGWEFPTNAKKLR 459

  Fly   447 ---------------------------GYSIDLINEIAKMLNFKFEFRM----SPDGKYGALNKV 480
                                       |:.||:.|.:...:.:...:..    :|||      |.
plant   460 IAVPKKDGFNNFVEVTKDENTNVPTVTGFCIDVFNTVMSQMPYAVSYEYIPFDTPDG------KP 518

  Fly   481 TQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPF 545
            ..::|.:|..:..|..|..:.|.|:.::|...|||..|:...||..|...........:.||.|.
plant   519 RGSYDEMVYNVFLGEFDGAVGDTTILANRSHYVDFALPYSETGIVFLVPVKDGKEKGEWVFLKPL 583

  Fly   546 SLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIWSIMNTTWLSIGSLMGQGCD 610
            :.::|:...:::|:|.::::.....|.:::      :|...::.|.|:.   :.|..:|.
plant   584 TKELWLVTAASFLYIGIMVWIFEYQADEEF------REQMIIDKISSVF---YFSFSTLF----- 634

  Fly   611 ILPKAAS----TRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMA 671
            ...:..|    ||::..:|.|..|::..||||.|.:.||......::...:|| .:|.:..|...
plant   635 FAHRRPSESFFTRVLVVVWCFVLLILTQSYTATLTSMLTVQELRPTVRHMDDL-RKSGVNIGYQT 698

  Fly   672 GGSTMGFFRDSNFSTYQ-KMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVER 735
            |..|....:...|...: |.:.:.|........|:::.|::............|.....||::..
plant   699 GSFTFERLKQMRFDESRLKTYNSPEEMRELFLHKSSNGGIDAAFDEVAYIKLFMAKYCSEYSIIE 763

  Fly   736 ---KCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEK 797
               |.|           .:|.|.|..||....||..:|.:.|...:..::.||:.   |..:|
plant   764 PTFKAD-----------GFGFAFPLGSPLVSDISRQILNITEGDAMKAIENKWFL---GEKHC-- 812

  Fly   798 SDEDGGDTP-ELGLENVGGVFLVL 820
            .|....|:| :|...:...:||::
plant   813 LDSTTSDSPIQLDHHSFEALFLIV 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	89/425 (21%)
		ANF_receptor	39..379	CDD:279440	81/395 (21%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	82/415 (20%)
		Lig_chan	548..812	CDD:278489	55/272 (20%)
GLR2.5	NP_001332219.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.880