DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and GLR3.6

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001326369.1	Gene:	GLR3.6 / 824311	AraportID:	AT3G51480	Length:	903	Species:	Arabidopsis thaliana

Alignment Length:	986	Identity:	211/986 - (21%)
Similarity:	385/986 - (39%)	Gaps:	209/986 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VGSIFTSDK---DESEIAFRTAVDRAN----ILERNVELVPIVVYANTDDSF--IMEKMVCNLIS 82
            :||:||.:.   ...::|...||:..|    ||  |...:.|:::....:.|  |||.:  ..:.
plant    32 IGSVFTFNSLIGKVIKVAMDAAVEDVNASPSIL--NTTTLRIIMHDTKYNGFMSIMEPL--QFME 92

  Fly    83 QGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMT----LNVHPDNLLLSQ 143
            ...:||.||...:::.::|.:...|.||.:.:      |..|...|.:.    :....::|....
plant    93 SETVAIIGPQRSTTARVVAHVATELKIPILSF------SATDPTMSPLQFPFFIRTSQNDLFQMA 151

  Fly   144 GLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISN--------------PTTVKQLGPGDD 194
            .:|:|||.:.||....:|..|.  .....:..:|:.:|.              ||.       ::
plant   152 AIADIVQFYGWREVVAIYGDDD--YGRNGVAALGDRLSEKRCRISYKAALPPAPTR-------EN 207

  Fly   195 HRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFI--------PLLDTHS-IDF 250
            ....|.::.||....:::|.   :.:..|:..|..:.||...:.::        .::||.| :..
plant   208 ITDLLIKVALSESRIIVVHA---SFIWGLELFNVARNLGMMSTGYVWIATNWLSTIIDTDSPLPL 269

  Fly   251 GELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWL---- 311
            ..::.:: .:.|:||..|:....:|.|..|.          .:....:.:..:...|.|||
plant   270 DTINNIQ-GVITLRLHTPNSIMKQNFVQRWH----------NLTHVGLSTYALYAYDTVWLLAQA 323

  Fly   312 ----FSKG----LTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQR 368
                |.||    .::..|..||...:|.....|.:..||..:|.|........|||:.|..:  |
plant   324 IDDFFKKGGNVSFSKNPIISELGGGNLHLDALKVFDGGKIFLESILQVDRIGLTGRMKFTSD--R 386

  Fly   369 SFFTLRFMELN--SDGFLDLATWDPVNGLDVLNDDE-ESEKRVGQKLSN-----------KTFIV 419
            :.....|..||  ..|:..:..|...:||.|:..|| |:....||||.:           :.::.
plant   387 NLVNPAFDVLNVIGTGYTTIGYWFNHSGLSVMPADEMENTSFSGQKLHSVVWPGHSIKIPRGWVF 451

  Fly   420 SS-----RLGAP----FLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYG 475
            |:     |:|.|    |      :|...:..|....|:.:|:......:|.:...|.:...|. |
plant   452 SNNGRHLRIGVPNRYRF------EEVVSVKSNGMITGFCVDVFIAAINLLPYAVPFELVAFGN-G 509

  Fly   476 ALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDL-- 538
            ..|.....   :||.:..|..|.|:.|:|:.:.|.:..|||.|::..|:.::     .|...|
plant   510 HDNPSNSE---LVRLITTGVYDAGVGDITIITERTKMADFTQPYVESGLVVV-----APVRKLGS 566

  Fly   539 --FSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIWSIMNTTWLSI 601
              .:||.||:..:|:...:::|.:..:::.|.....|::..| |.::         ::.|.|.|.
plant   567 SAMAFLRPFTPQMWLIAAASFLIVGAVIWCLEHKHNDEFRGP-PRRQ---------VITTFWFSF 621

  Fly   602 GSLMGQGCDILPKAAST----RLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAA- 661
            .:|.     ...:..:|    |:|..:|.|..|::.:||||:|.:.||..:.::.|...|.|..
plant   622 STLF-----FSHRETTTSNLGRIVLIIWLFVVLIINSSYTASLTSILTVHQLSSPIKGIETLQTN 681

  Fly   662 QSKIKYGAMAGGSTMGFFRD---SNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGK-NLYAF 722
            ...|.|   ..||   |.||   ...:.:......:.  ||..:.|...:|     .|| .:.|.
plant   682 HDPIGY---PQGS---FVRDYLIHELNIHVSRLVPLR--SPEEYDKALRDG-----PGKGGVAAV 733

  Fly   723 LMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWK 787
            :.|...:|..:..:|:...:|.......:|.|.|.|||....:|||:|:|.|.|.:..::.||.
plant   734 VDERAYIELFLSNRCEFGIVGQEFTKNGWGFAFPRNSPLAVDVSAAILQLSENGDMQRIRDKWL- 797

  Fly   788 EMHGGGNCEKSDEDGG---DTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKIS 849
                   ..|:....|   :...|.|::..|:|:|.|:..:.|:              |:...:.
plant   798 -------LRKACSLQGAEIEVDRLELKSFWGLFVVCGVACVLAL--------------AVYTVLM 841

  Fly   850 LKEAFKSEALFAARIWITTKPVHTSSESGSSNSSSSSSSRSKHSF------KSQGLSMKSLKSSG 908
            ::: |..:.              .....||....||.|:|. |||      |.:....:|.:...
plant   842 IRQ-FGQQC--------------PEEAEGSIRRRSSPSARI-HSFLSFVKEKEEDAKARSSRERQ 890

  Fly   909 YQDVEASVHSK 919
            .:|:.|:..|:
plant   891 LEDISANGSSR 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	85/418 (20%)
		ANF_receptor	39..379	CDD:279440	76/384 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	92/405 (23%)
		Lig_chan	548..812	CDD:278489	63/275 (23%)
GLR3.6	NP_001326369.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780