DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and GLR1.1

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_187061.1	Gene:	GLR1.1 / 819566	AraportID:	AT3G04110	Length:	808	Species:	Arabidopsis thaliana

Alignment Length:	870	Identity:	168/870 - (19%)
Similarity:	336/870 - (38%)	Gaps:	227/870 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FRTAVDRANILERNVELVPIVVYANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDT 106
            :||   |.::|.|:.:..||:..|...|      ::.|..::   ||.|..:...:.::|:|.:.
plant    64 YRT---RVSVLVRDSQGDPIIALAAATD------LLKNAKAE---AIVGAQSLQEAKLLATISEK 116

  Fly   107 LDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLL--------SQGLAEIVQSFAWRSFTVVYE- 162
            ..:| ::..::||         |::|..: ||.:.        ::|:..::|.|:.:|..|:||
plant   117 AKVP-VISTFLPN---------TLSLKKY-DNFIQWTHDTTSEAKGITSLIQDFSCKSVVVIYED 170

  Fly   163 TDKELQQLQDILQ----VGEPISNPTTVKQLGPGDDH-RPFLKEIKLSTDNCLILHCAPDNLLKI 222
            .|...:.||.:::    .|..|:...:......|::| ...|:::|:|..:..::|.:...:.::
plant   171 ADDWSESLQILVENFQDKGIYIARSASFAVSSSGENHMMNQLRKLKVSRASVFVVHMSEILVSRL 235

  Fly   223 LQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITTV---RLMDPSDFHVKNVVHDWEERE 284
            .|...:|.::.|   .|..:|...::::.|...:..::..|   :...|....|||..   ....
plant   236 FQCVEKLGLMEE---AFAWILTARTMNYLEHFAITRSMQGVIGFKSYIPVSEEVKNFT---SRLR 294

  Fly   285 KREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIK 349
            ||.|     |....:...:::.                  |.|.|:.|               |.
plant   295 KRMG-----DDTETEHSSVIIG------------------LRAHDIAC---------------IL 321

  Fly   350 ARSEE--TSTGRIDFNENGQRSFF-TLRF---------MELNSDGFLDLATWDPVNGLDVLNDDE 402
            |.:.|  :.:|:::.:.|...... |:|.         ::::.:.|:.       ...:::|...
plant   322 ANAVEKFSVSGKVEASSNVSADLLDTIRHSRFKGLSGDIQISDNKFIS-------ETFEIVNIGR 379

  Fly   403 ESEKRV----GQKLSNKTFIV---SSRLGAPFLTLREPQEGEIL--------------------- 439
            |.::|:    |...|.:..||   .||.......|.|..|.::|
plant   380 EKQRRIGLWSGGSFSQRRQIVWPGRSRKIPRHRVLAEKGEKKVLRVLVTAGNKVPHLVSVRPDPE 444

  Fly   440 TGNSRYEGYSIDLINEIAKMLNFKFEF---RMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGIC 501
            ||.:...|:.:::........|::.||   |.:.|.....|:.....:|..|.
plant   445 TGVNTVSGFCVEVFKTCIAPFNYELEFIPYRGNNDNLAYLLSTQRDKYDAAVG------------ 497

  Fly   502 DLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFA 566
            |:|:||:|...||||.|:..:||.||..|..:  ..:::|..||...:|:..|:.::...::::.
plant   498 DITITSNRSLYVDFTLPYTDIGIGILTVKKKS--QGMWTFFDPFEKSLWLASGAFFVLTGIVVWL 560

  Fly   567 LARMAPDDWENPHPCKEPEEVENIW----SIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWF 627
            :.|..     ||       |.:..|    |:|  .|....:::....:.|.|.:|..||. :|.|
plant   561 VERSV-----NP-------EFQGSWGQQLSMM--LWFGFSTIVFAHREKLQKMSSRFLVI-VWVF 610

  Fly   628 FALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWT 692
            ..|::.:||:|||.:..|.||.              ::.:..:.||||                |
plant   611 VVLILTSSYSANLTSTKTISRM--------------QLNHQMVFGGST----------------T 645

  Fly   693 AMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVER-----------KCDLVQIGGWL 746
            :|.:...|:      ..||       .||.|:...||.:.:..           ..|.|......
plant   646 SMTAKLGSI------NAVE-------AYAQLLRDGTLNHVINEIPYLSILIGNYPNDFVMTDRVT 697

  Fly   747 DYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHG---GGNCEK---SDEDGGDT 805
            :...:|......|....::|..:.||..||.|.::::||::::..   ..|.|:   :::|...:
plant   698 NTNGFGFMFQKGSDLVPKVSREIAKLRSLGMLKDMEKKWFQKLDSLNVHSNTEEVASTNDDDEAS 762

  Fly   806 PELGLENVGGVFLVLGLGLLSAMVL 830
            .......:.|:|::.|...:..:.|
plant   763 KRFTFRELRGLFIIAGAAHVLVLAL 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	67/382 (18%)
		ANF_receptor	39..379	CDD:279440	66/365 (18%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	89/414 (21%)
		Lig_chan	548..812	CDD:278489	55/284 (19%)
GLR1.1	NP_187061.1	PBP1_GABAb_receptor	31..397	CDD:107361	72/406 (18%)
		ANF_receptor	45..377	CDD:279440	67/386 (17%)
		Periplasmic_Binding_Protein_Type_2	421..737	CDD:304360	81/387 (21%)
		Lig_chan	542..781	CDD:278489	58/296 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.880