DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and GLR2.8

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001324459.1	Gene:	GLR2.8 / 817459	AraportID:	AT2G29110	Length:	948	Species:	Arabidopsis thaliana

Alignment Length:	1091	Identity:	225/1091 - (20%)
Similarity:	385/1091 - (35%)	Gaps:	334/1091 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FLTHF--LLIALPV-LADIDRSQFMVGSIFTSDKDESEIAFRTAV---------DRANILERNVE 57
            ||::|  |.:.|.| |.....|:..||.:...:...|:|.. |::         |..|...|
plant    11 FLSYFVCLFLLLEVGLGQNQISEIKVGVVLDLNTTFSKICL-TSINLALSDFYKDHPNYRTR--- 71

  Fly    58 LVPIVVYANTDDSFIMEKMVCNLI-SQGVIAIFGPSTGSSSDIIASICDTLDIPHIVY------- 114
             :.:.|..:..|:........:|| ::.|.||.||.....:..:..:.:...:|.|.:
plant    72 -LALHVRDSMKDTVQASAAALDLIQNEQVSAIIGPIDSMQAKFMIKLANKTQVPTISFSATSPLL 135

  Fly   115 -----DWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQ----- 169
                 |:....:|              |:....:.:|.|.:||.|||...:| .|.||.:
plant   136 TSIKSDYFVRGTI--------------DDSYQVKAIAAIFESFGWRSVVAIY-VDNELGEGIMPY 185

  Fly   170 ----LQDILQVGEPISNPTTVKQLGPGDDHRPFLKEI-KLST--DNCLILHCAPDNLLKILQQAN 227
                |||: ||...:. |:..     .||.  .|||: ||.|  ....::|.|.....:|.::|.
plant   186 LFDALQDV-QVDRSVI-PSEA-----NDDQ--ILKELYKLMTRQTRVFVVHMASRLASRIFEKAT 241

  Fly   228 ELKMLGEYQSVFIPLLD---TH------------SIDFGELSGVEANITTVRLMDPSDFHVKNVV 277
            |:.|:.|   .::.|:.   ||            :|| |.| ||.:::...:.::  ||.::
plant   242 EIGMMEE---GYVWLMTNGMTHMMRHIHHGRSLNTID-GVL-GVRSHVPKSKGLE--DFRLR--- 296

  Fly   278 HDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLF--------------------------SKGL 316
              |:...|:|..:.:.|         |....:|.:                          |..:
plant   297 --WKRNFKKENPWLRDD---------LSIFGLWAYDSTTALAMAVEKTNISSFPYNNASGSSNNM 350

  Fly   317 TELG-----------------------------IFEELTAPDLECRRKKPWPFGKRIIEFIKARS 352
            |:||                             |..:|.:|..|            ||.|:  .:
plant   351 TDLGTLHVSRYGPSLLEALSEIRFNGLAGRFNLIDRQLESPKFE------------IINFV--GN 401

  Fly   353 EE-------TSTGRIDFNENGQRSFFTLRFMELNSDGFLDLAT--WD-PVNGLDVLNDDEESEKR 407
            ||       .|.|.::.|.|...||...||..|...|...:..  |: |.||..:         :
plant   402 EERIVGFWTPSNGLVNVNSNKTTSFTGERFGPLIWPGKSTIVPKGWEIPTNGKKI---------K 457

  Fly   408 VGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKML-------NFKFE 465
            ||..:....|.....:..|...:..|            :||:||:.....|.|       .::||
plant   458 VGVPVKKGFFNFVEVITDPITNITTP------------KGYAIDIFEAALKKLPYSVIPQYYRFE 510

  Fly   466 FRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSK 530
               |||..|          |.:|.::.:|..|..:.|:|:|:.|....|||.|:...|:|::...
plant   511 ---SPDDDY----------DDLVYKVDNGTLDAVVGDVTITAYRSLYADFTLPYTESGVSMMVPV 562

  Fly   531 PPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIWSIMN 595
            ......:.:.||.|:.||:|:.....::.|..:::........|:..|     |..     .|..
plant   563 RDNENKNTWVFLKPWGLDLWVTTACFFVLIGFVVWLFEHRVNTDFRGP-----PHH-----QIGT 617

  Fly   596 TTWLSIGSLMGQGCDILPKAAS--TRLVTGMWWFFALMMLNSYTANLAAFLTNSR-QANSINSAE 657
            :.|.|..:::....:   |..|  .|.|..:|.|..|::..||||||.:|||..| |..:|| .:
plant   618 SFWFSFSTMVFAHRE---KVVSNLARFVVVVWCFVVLVLTQSYTANLTSFLTVQRFQPAAIN-VK 678

  Fly   658 DLAAQSKIKYGAMAGGSTMGFFRD------SNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKG 716
            ||     ||.|...|.....|.:|      .|.|..:...::              |....:...
plant   679 DL-----IKNGDYVGYQHGAFVKDFLIKEGFNVSKLKPFGSS--------------EECHALLSN 724

  Fly   717 KNLYAFLMESTTLEYNVERKCDLVQI-------GGWLDYKSYGIAMPFNSPYRKQISAAVLKLGE 774
            .::.|...|...|...:.:.|....|       .|      :|.|.|.|||....:|.|:|.:.:
plant   725 GSISAAFDEVAYLRAILSQYCSKYAIVEPTFKTAG------FGFAFPRNSPLTGDVSKAILNVTQ 783

  Fly   775 LGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPE---------LGLENVGGVFLVLGLGLLSAMVL 830
            ..::..::.||:.:.:             |.|:         |.|.:..|:||:.|:....|:::
plant   784 GDEMQHIENKWFMKQN-------------DCPDPKTALSSNRLSLRSFWGLFLIAGIASFLALLI 835

  Fly   831 GCTEFLWNVKSVA------------------IEEKISLKEAFKSEALF------------AARIW 865
            ....||:..:...                  .:||......|||.|:.            .:.:.
plant   836 FVFLFLYENRHTLCDDSEDSIWRKLTSLFRNFDEKDIKSHTFKSSAVHHVSSPMTQYIPSPSTLQ 900

  Fly   866 ITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASV 916
            |..:| |:.|:..:......|.:.::....:|.:..:..:|    |:|..|
plant   901 IAPRP-HSPSQDRAFELRRVSFTPNEERLTTQTIHFEDEES----DIECVV 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	98/483 (20%)
		ANF_receptor	39..379	CDD:279440	89/450 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	90/395 (23%)
		Lig_chan	548..812	CDD:278489	61/288 (21%)
GLR2.8	NP_001324459.1	PBP1_GABAb_receptor_plant	35..419	CDD:380645	86/447 (19%)
GLR2.8	NP_001324459.1	GluR_Plant	454..795	CDD:270404	91/413 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.880