DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and GLR2.2

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_180048.1	Gene:	GLR2.2 / 817008	AraportID:	AT2G24720	Length:	920	Species:	Arabidopsis thaliana

Alignment Length:	856	Identity:	178/856 - (20%)
Similarity:	316/856 - (36%)	Gaps:	194/856 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQ--GLAE 147
            |.||.||.|...:..:..|.....:|.:.|. ..:.|:............:.|:   ||  .:..
plant    97 VKAILGPWTSMQAHFLIEIGQKSRVPVVSYS-ATSPSLTSLRSPYFFRATYEDS---SQVHAIKA 157

  Fly   148 IVQSFAWRSFTVVY--ETDKE--LQQLQDILQVGEPISNPTTVKQLGP-----GDDHRPFLKEIK 203
            |::.|.||....||  .|..|  :.:|.|.||   .|:.....:.:.|     .|.....||.:.
plant   158 IIKLFGWREVVPVYIDNTFGEGIMPRLTDSLQ---DINVRIPYRSVIPLNATDQDISVELLKMMN 219

  Fly   204 LSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEA-NITTVRLMD 267
            :.| ...|:|.:......:..:|.|   ||..:..::.:|..     |.:.|:.: |.|.:..|:
plant   220 MPT-RVFIVHMSSSLASTVFIKAKE---LGLMKPGYVWILTN-----GVMDGLRSINETGIEAME 275

  Fly   268 PSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLF------SKGLTELGIFEELT 326
             ....:|..:...::.|....|:.:..|     ||.|....:|.:      :..:.:.|| ..:|
plant   276 -GVLGIKTYIPKSKDLETFRSRWKRRFP-----QMELNVYGLWAYDATTALAMAIEDAGI-NNMT 333

  Fly   327 APDLECRRKKP-------WPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFL 384
            ..:::..:...       ..||.::::.:.....:...|...| .:||........:.:...|..
plant   334 FSNVDTGKNVSELDGLGLSQFGPKLLQTVSTVQFKGLAGDFHF-VSGQLQPSVFEIVNMIGTGER 397

  Fly   385 DLATWDPVNGLDVLNDDEESE------------KRV------------------GQKLSNKTFIV 419
            .:..|...||| |...|:|..            |.:                  |:||
plant   398 SIGFWTEGNGL-VKKLDQEPRSIGTLSTWPDHLKHIIWPGEAVSVPKGWEIPTNGKKL------- 454

  Fly   420 SSRLGAP----FLTL----REPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGA 476
              |:|.|    |..|    |:|     :|.::..:|:.||....:.:.:.:...:...|..|..
plant   455 --RIGVPKRIGFTDLVKVTRDP-----ITNSTVVKGFCIDFFEAVIQAMPYDVSYEFFPFEKPN- 511

  Fly   477 LNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSF 541
             .:.....:.:|.|:..|..|..:.|.|:.::|...||||.|||..|:.::.........|.|||
plant   512 -GEPAGNHNDLVHQVYLGQFDAVVGDTTILANRSSFVDFTLPFMKSGVGLIVPLKDEVKRDKFSF 575

  Fly   542 LSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIWSIMNTTWLSIGSLMG 606
            |.|.|:::|:.....:..:.:.::.|......|:..|..          :......|.:..:::.
plant   576 LKPLSIELWLTTLVFFFLVGISVWTLEHRVNSDFRGPAN----------YQASTIFWFAFSTMVF 630

  Fly   607 QGCD-ILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAM 670
            ...: :|...|.:.:||  |:|..|::..||||:||:.||:.:...:|.|...|          :
plant   631 APRERVLSFGARSLVVT--WYFVLLVLTQSYTASLASLLTSQQLNPTITSMSSL----------L 683

  Fly   671 AGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGK------------------ 717
            ..|.|:|:.|.| |...:...|....:|...| .|.:|..|.::||.
plant   684 HRGETVGYQRTS-FILGKLNETGFPQSSLVPF-DTAEECDELLKKGPKNGGVAAAFLGTPYVRLF 746

  Fly   718 -----NLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQ 777
                 |.|..:.|    .:||:               .:|...|..||....:|.|:||:.|..:
plant   747 LGQYCNTYKMVEE----PFNVD---------------GFGFVFPIGSPLVADVSRAILKVAESPK 792

  Fly   778 LAELKRKWWKEMHGGGNCEKSDEDGGDTP---------ELGLENVGGVFLVLGLGLLSAMVLG-- 831
            ..||:..|:|:.      |:|..|....|         :||:.:...:|||  :.::..:.||
plant   793 AVELEHAWFKKK------EQSCPDPVTNPDSNPTVTAIQLGVGSFWFLFLV--VFVVCVLALGKF 849

  Fly   832 --CTEFLWNVK 840
              |  |||..|
plant   850 TFC--FLWKTK 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	64/335 (19%)
		ANF_receptor	39..379	CDD:279440	60/318 (19%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	89/404 (22%)
		Lig_chan	548..812	CDD:278489	61/296 (21%)
GLR2.2	NP_180048.1	PBP1_GABAb_receptor	33..412	CDD:107361	66/339 (19%)
		ANF_receptor	47..392	CDD:279440	60/318 (19%)
		HisJ	438..>587	CDD:223904	39/164 (24%)
		GluR_Plant	452..801	CDD:270404	90/407 (22%)
		Lig_chan	582..819	CDD:278489	59/285 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.880