DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and GLR2.3

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001325281.1	Gene:	GLR2.3 / 817007	AraportID:	AT2G24710	Length:	919	Species:	Arabidopsis thaliana

Alignment Length:	948	Identity:	195/948 - (20%)
Similarity:	352/948 - (37%)	Gaps:	200/948 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LIALPVLADIDRSQFMVG----SIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYANTDDSF 71
            |:.:.|:.|:|.|...|.    ::..||...|...|.|.: ..|:.:...::|...:.|
plant    54 LVDVGVVTDVDTSHSKVVMLCINMSISDFYSSNPQFETRL-VVNVGDSKSDVVGAAIAA------ 111

  Fly    72 IMEKMVCNLI-SQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVH 135
                  .:|| ::.|.||.||.|...:..:..|.....:|.:.|.  ....|.....|...|...
plant   112 ------LDLIKNKQVKAILGPWTSMQAHFLIEIGQKSRVPIVSYS--ATSPILTSLRSPYFLRAT 168

  Fly   136 PDNLLLSQGLAEIVQSFAWRSFTVVY--ETDKE--LQQLQDILQ---VGEPISNPTTVKQLGPGD 193
            .::....|.:..|::.|.||....||  .|..|  :.:|.|.||   |..|..:...:.    ..
plant   169 YEDSFQVQPIKAIIKLFGWREVVPVYIDNTFGEGIMPRLTDALQDINVRIPYRSVIAIN----AT 229

  Fly   194 DHR---PFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSG 255
            ||.   ..||.:.:.| ...::|...|...:...:|.|   ||..:..::.:|....||  :||.
plant   230 DHEISVELLKMMNMPT-RVFLVHMYYDLASRFFIKAKE---LGLMEPGYVWILTNGVID--DLSL 288

  Fly   256 VEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELG 320
            :  |.|.|..|: ....:|..:....:.||...|:..:.| ||:..:.    .:|.:. ..|.|.
plant   289 I--NETAVEAME-GVLGIKTYIPKSPDLEKFRSRWRSLFP-RVELSVY----GLWAYD-ATTALA 344

  Fly   321 I-FEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSD--- 381
            : .||....::        .|.| :::..:..||..:.|...|.....::..|::|..|..:
plant   345 VAIEEAGTNNM--------TFSK-VVDTGRNVSELEALGLSQFGPKLLQTLLTVQFRGLAGEFRF 400

  Fly   382 --GFLDLATWDPVNGLDVLNDDEESEKRVG---------QKLSNKTFIVSS-------------- 421
              |.|..:.::.||   ::|   ..||.:|         :||..:...:|:
plant   401 FRGQLQPSVFEIVN---IIN---TGEKSIGFWKEGNGLVKKLDQQASSISALSTWKDHLKHIVWP 459

  Fly   422 -------------------RLGAPFLT--------LREPQEGEILTGNSRYEGYSIDLINEIAKM 459
                               |:|.|..|        .|:|     :|.::...|:.||....:.:.
plant   460 GEADSVPKGWQIPTKGKKLRIGVPKRTGYTDLVKVTRDP-----ITNSTVVTGFCIDFFEAVIRE 519

  Fly   460 LNFKFEFRM----SPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFM 520
            |.:...:..    .|||      |....::.:|.|:..|..|..:.|.|:..:|...||||.||:
plant   520 LPYDVSYEFIPFEKPDG------KTAGNYNDLVYQVYLGRYDAVVGDTTILVNRSSYVDFTFPFI 578

  Fly   521 TLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPE 585
            ..|:.::.........|...|:.|.|..:|:....::..:...::.|......|:..|     |.
plant   579 KSGVGLIVEMTDPVKRDYILFMKPLSWKLWLTSFISFFLVGCTVWVLEYKRNPDFSGP-----PR 638

  Fly   586 EVENIWSIMNTTWLSIGSLMGQGCDILPK----AASTRLVTGMWWFFALMMLNSYTANLAAFLTN 646
                 :......|.:..:::     ..|:    :...|.:...|:|..|::..||||:||:.||:
plant   639 -----FQASTICWFAFSTMV-----FAPRERVFSFWARALVIAWYFLVLVLTQSYTASLASLLTS 693

  Fly   647 SRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDS-NFSTYQKMWTAMESASPSVFTKTNDEGV 710
            .:...:|.|...|          :..|.|:|:.|.| .....::......|..|....:..||.:
plant   694 QKLNPTITSMSSL----------LEKGETVGYQRTSFILGKLKERGFPQSSLVPFDTAEECDELL 748

  Fly   711 ERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYK---------SYGIAMPFNSPYRKQIS 766
            .:..|...:....:|...|...:.:.|:        .||         .:|...|..||....:|
plant   749 SKGPKKGGVSGAFLEIPYLRLFLGQFCN--------TYKMVEEPFNVDGFGFVFPIGSPLVADVS 805

  Fly   767 AAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTP---------ELGLENVGGVFLVLGL 822
            .|:||:.|..:..||:|.|:|:.      |:|..|....|         :|.:::.  :||.:|:
plant   806 RAILKVAESPKAMELERAWFKKK------EQSCPDPITNPDPNPSFTSRQLDIDSF--LFLFVGV 862

  Fly   823 GLLSAMVLGCTEFLWNVK-SVAIEEKISLKEAFKSEAL 859
            .|:..|.||...:.:..| .|:..:|:.:.....|:.:
plant   863 LLVCVMALGNFTYCFLAKDQVSYLDKVEMSPCSSSQQM 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	83/390 (21%)
		ANF_receptor	39..379	CDD:279440	74/351 (21%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	84/431 (19%)
		Lig_chan	548..812	CDD:278489	56/286 (20%)
GLR2.3	NP_001325281.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.880