DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and GLR2

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	984	Identity:	204/984 - (20%)
Similarity:	376/984 - (38%)	Gaps:	217/984 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VGSIF---TSDKDESEIAFRTAVDRANILERNVELVPIVVYANTDDSFIMEKMVCNLISQG---- 84
            ||:||   |...:.:.|||:.|       |.:|         |:|.||:....:..|::..
plant    36 VGAIFGLNTMYGETANIAFKAA-------EEDV---------NSDPSFLGGSKLRILMNDAKRSG 84

  Fly    85 --------------VIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVH 135
                          |:||.||.|...:.:::.:.:.|.:|.:.:..:.....|  ......:...
plant    85 FLSIMGALQFMETDVVAIIGPQTSIMAHVLSHLANELTVPMLSFTALDPTLSP--LQFPFFVQTA 147

  Fly   136 PDNLLLSQGLAEIVQSFAWRSFTVVYETD-----------KELQQ------LQDILQVGEPISNP 183
            |.:|.|.:.:||::..:.|.....:|..|           .||::      .:.:|.:...|::|
plant   148 PSDLFLMRAIAEMITYYGWSDVVALYNDDDNSRNGVTALGDELEERRCKISYKAVLPLDVVITSP 212

  Fly   184 TTVKQLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFI------PL 242
            ..:.:         .|.:|:......::::..|:....|.::|..|.|: |...|:|      .:
plant   213 VEIIE---------ELIKIRGMESRVIVVNTFPNTGKMIFKEAERLGMM-EKGYVWIATTWLSSV 267

  Fly   243 LDTH-SIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLN 306
            ||:: .:|...::||    .|:||..|.....::....|:.         |:..|:.    |.||
plant   268 LDSNLPLDTKLVNGV----LTLRLHTPDSRKKRDFAARWKN---------KLSNNKT----IGLN 315

  Fly   307 -------DAVWLFS---KGLTELG---------IFEELTAPDLECRRKKPWPFGKRIIEFIKARS 352
                   |.||:.:   |.|.|.|         ....|....|.......:..|.:::::|....
plant   316 VYGLYAYDTVWIIARAVKTLLEAGGNLSFSNDAKLGSLKGEALNLSALSRFDQGSQLLDYIVHTK 380

  Fly   353 EETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNK-- 415
            ....||.:.|:.:......:...:.|..|....:..|...:||.::..:....|...:..||:
plant   381 MSGLTGPVQFHPDRSMLQPSYDIINLVDDRVHQIGYWSNYSGLSIVPPESFYSKPPNRSSSNQHL 445

  Fly   416 --------TFIVSS-----------RLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLN 461
                    |.:...           |:|.|.....:.....:...:::.:||.||:.....|:|:
plant   446 NSVTWPGGTSVTPRGWIFRNNGRRLRIGVPDRASFKDFVSRVNGSSNKVQGYCIDVFEAAVKLLS 510

  Fly   462 F--KFEFRMSPDG----KYGAL-NKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPF 519
            :  ..||....||    .|..| ||||..        :|.:|.:|  |:.:.:.|.:.||||.|:
plant   511 YPVPHEFIFFGDGLTNPNYNELVNKVTTG--------VDFDAVVG--DIAIVTKRTRIVDFTQPY 565

  Fly   520 MTLGISILFSKPPTPPTDL----FSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHP 580
            :..|:.::     .|.|.|    ::||.||:|.:|....|.::.:...::.|.....|::..|
plant   566 IESGLVVV-----APVTRLNENPWAFLRPFTLPMWAVTASFFVIVGAAIWILEHRINDEFRGP-- 623

  Fly   581 CKEPEEVENIWSIMNTTWLS----IGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLA 641
             ...:.:..:|...:|.:.|    ..|.:|            |:|..:|.|..|::.:||||:|.
plant   624 -PRRQIITILWFTFSTMFFSHRETTVSTLG------------RMVLLIWLFVVLIITSSYTASLT 675

  Fly   642 AFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDS-NFSTYQKMWTAMESASPSVFTKT 705
            :.|| .:|.||.....|....|..:.|...|.....:..|. |.::.:    .:..|||..:...
plant   676 SILT-VQQLNSPIKGVDTLISSTGRIGFQVGSFAENYMTDELNIASSR----LVPLASPEEYANA 735

  Fly   706 NDEGVERVQKGKNLYAFLMESTTLEYNVE----RKCDLVQIGGWLDYKSYGIAMPFNSPYRKQIS 766
            ...|.......:..|..|..|...::.:.    .:|      ||      |.|.|.:||....:|
plant   736 LQNGTVAAIVDERPYIDLFLSDYCKFAIRGQEFTRC------GW------GFAFPRDSPLAVDMS 788

  Fly   767 AAVLKLGELGQLAELKRKWWKEMHGGGNCEK-SDEDGGDTPELGLENVGGVFLVLGLGLLSAMVL 830
            .|:|.|.|.|:|.::..:|..:    .||.. .....||:.:|.:.:..|:|||:|:..|.|:.:
plant   789 TAILGLSETGELQKIHDRWLSK----SNCSSPHGSQSGDSEQLNVHSFWGMFLVVGIACLVALFI 849

  Fly   831 G----CTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHT---------SSESGSSNS 882
            .    ..:|..:...|.:||.|...::.:...|.....::..|...|         :..|.::||
plant   850 HFFKIIRDFCKDTPEVVVEEAIPSPKSSRLTKLQTFLAFVDEKEEETKRRLKRKRNNDHSMNANS 914

  Fly   883 --SSSSSSR 889
              |.::|.|
plant   915 IISRTASRR 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	81/432 (19%)
		ANF_receptor	39..379	CDD:279440	72/400 (18%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	94/413 (23%)
		Lig_chan	548..812	CDD:278489	59/273 (22%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	81/432 (19%)
		GluR_Plant	468..808	CDD:270404	91/386 (24%)
		Lig_chan	594..843	CDD:306551	64/284 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780