DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clumsy and grik1a

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	XP_009303592.1	Gene:	grik1a / 798001	ZFINID:	ZDB-GENE-030131-6502	Length:	919	Species:	Danio rerio

Alignment Length:	864	Identity:	314/864 - (36%)
Similarity:	501/864 - (57%)	Gaps:	73/864 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VGSIFTSDKDE----SEIAFR---TAVDRANILERNVELVPIVVYANTDDSFIMEKMVCNLISQG 84
            :|.||.:.::|    .|:||:   |:::|...|..|..|...:...|..|||...:.||:.::.|
Zfish    41 IGGIFETRENEPVSMDELAFKFAVTSINRNRTLMPNTTLTYDIQRVNLFDSFEASRRVCDQLALG 105

  Fly    85 VIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEIV 149
            |.|:||||..||...:.|||:.|::|||...| .:.|:.::::  ..:|::|:...:|:.:.:||
Zfish   106 VAAVFGPSHSSSVSAVQSICNALEVPHIQTRW-KHPSVDNKDN--FYINLYPEYTSISRAILDIV 167

  Fly   150 QSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQL-GPGDDHRPFLKEIKLSTDNCLILH 213
            ..:.|:..|||||....|.::|::::.....:....::|| ..|.|.||.|||:|...:..:|..
Zfish   168 IFYKWKCVTVVYEDSTGLMRMQELIKAPSKNNLKIRIRQLPSGGGDSRPLLKEMKKEKEFYVIFD 232

  Fly   214 CAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFG--ELSGVEANITTVRLMDPSDFHVKNV 276
            |:.....::|:|...:.|:.||...|...||..::|..  ..|||  |:|..||::..|.:|.:|
Zfish   233 CSYQVAAELLKQLMSMGMMTEYYHFFFTTLDLFALDLEPYRYSGV--NMTAFRLLNLDDSYVASV 295

  Fly   277 VHDWE-EREKREGRYFKVDPNRVKSQMI---------LLNDAVWLF---SKGLTELGIFEELTAP 328
            :..|. ||:        :.|.:.:|.::         |:.|||::.   |:..|      ::|..
Zfish   296 IQKWSMERQ--------LAPPKPESGLMSGIMTTAAALMYDAVFMVAVASQRAT------QMTVS 346

  Fly   329 DLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNE-NGQRSFFTLRFMELNSDG---------- 382
            .|:|.|.|||.:|.|.:...|....:..||||..|: :|.|..|.|..:.|..||
Zfish   347 SLQCHRHKPWRYGPRFMNLFKEAQWDGLTGRIVLNKTDGLRKEFNLDLISLKEDGTAKRVADGAS 411

  Fly   383 -----FLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGN 442
                 :..:..|:...||::  .:.:..|.:...|:|:|.||::.|..|::..:  :..::|.||
Zfish   412 RPNKLWTKIGVWNSYTGLNL--TEIKDNKNITDSLANRTLIVTTILENPYVMYK--KSDKVLYGN 472

  Fly   443 SRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTS 507
            .|:|||.:||:.|::.:|.|.:|.::..||||||.|...: |:|:||:|||..|||.:..||:|.
Zfish   473 DRFEGYCLDLLKELSNILGFTYEVKLVTDGKYGAQNDKGE-WNGMVRELIDHIADLAVAPLTITY 536

  Fly   508 SRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAP 572
            .|.:.:||:.||||||||||:.||......:||||:|.:.|:|:|:..|.|.:|.:||.:||..|
Zfish   537 VREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLTPDIWMYVLLACLGVSCVLFVIARFTP 601

  Fly   573 DDWENPHPCKEPEE-VENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSY 636
            .:|.|||||....| |||.::::|:.|..:.:||.||.:::|||.|||::.|:||||.|::::||
Zfish   602 YEWYNPHPCNPSSEVVENNFTLLNSLWFGVAALMRQGSELMPKALSTRILGGIWWFFTLIIISSY 666

  Fly   637 TANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSV 701
            |||||||||..|..:.|:||:|||.|::|:|||:..||||.||:.|..|||:|||..|.|...:.
Zfish   667 TANLAAFLTVERMDSPIDSADDLAKQTRIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRKNTA 731

  Fly   702 FTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQIS 766
            ..|.:.:|:.||....  ||.|||||::||..:|.|:|.|:||.:|.|.||:..|..||||.:::
Zfish   732 LVKNSKDGITRVLTTD--YALLMESTSIEYITQRNCNLTQVGGLIDSKGYGVGTPIGSPYRDKVT 794

  Fly   767 AAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLG 831
            .|:|:|.|.|:|..:|.|||:    |..|  .:||..:...||:||:||:|:||..||:.::.:.
Zfish   795 IAILQLQEEGKLHMMKEKWWR----GNGC--PEEDSKEASALGVENIGGIFIVLAAGLVLSVFVA 853

  Fly   832 CTEFLW-NVKSVAIEEKIS 849
            ..||:: :.|:..|||.:|
Zfish   854 IGEFIYKSHKNSDIEECVS 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	115/407 (28%)
		ANF_receptor	39..379	CDD:279440	106/359 (30%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	173/373 (46%)
		Lig_chan	548..812	CDD:278489	121/264 (46%)
grik1a	XP_009303592.1	Periplasmic_Binding_Protein_Type_1	37..432	CDD:299141	116/411 (28%)
		ANF_receptor	57..398	CDD:279440	106/359 (30%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:304360	173/373 (46%)
		Lig_chan	577..846	CDD:278489	128/276 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.660