DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Grid2

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_077355.2	Gene:	Grid2 / 79220	RGDID:	68368	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	1042	Identity:	253/1042 - (24%)
Similarity:	453/1042 - (43%)	Gaps:	180/1042 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VGSIFTSDKDESEIAFRTAVDRANILERNVELVPI---VVYANTDDSFIMEKMVCNLISQGVIAI 88
            :|:||.....:.:..|||||...|..|..::...|   |.:.:.::.|...:..|.|::||::|:
  Rat    29 IGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILAL 93

  Fly    89 FGPSTGSSSDIIASICDTLDIPHIVYD----WIPNES---IPDREHSTMTLNVHPDNLLLSQGLA 146
            ......:|:..:.|:.|.:.|||:...    ..|...   .....:...||:|.|. :.|::.:.
  Rat    94 VSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPP-VYLNEVIL 157

  Fly   147 EIVQSFAWRSFTVVYETDKELQQLQDIL----QVGEPISNPTTVKQLGPGDDHRPFLKEIKLSTD 207
            .:|..:||:.|.:.|:::.:::.:|:.|    |.|..::.......:.         |.|....|
  Rat   158 RVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNIN---------KMITTLFD 213

  Fly   208 NCLI--LHCAPDNL---LKILQQANELKMLGEYQSVFIPLLDTHSIDFG-ELSGVE--------- 257
            ...|  |:...|.|   :.::..|.....:.|.....:...|.|.|... |::.|:
  Rat   214 TMRIEELNRYRDTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSI 278

  Fly   258 ANITTVR-----------------------LMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVK 299
            ..:|.:|                       |.||.|...:|:               ::....:.
  Rat   279 GRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNM---------------EISNLYIY 328

  Fly   300 SQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRK--KPWPFGKRIIEFIKARSEETSTGRIDF 362
            ..::||.:|   |.|.|.:.   :..:...|.|.||  |||..|:.::|.||.......||.::|
  Rat   329 DTVLLLANA---FHKKLEDR---KWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEF 387

  Fly   363 NENGQRSFFTLRFMELN-----SDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSR 422
            .|||.........:..|     ..|...|..|:||.||    :...::|::...:......|.:.
  Rat   388 GENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGL----NGSLTDKKLENNMRGVVLRVVTV 448

  Fly   423 LGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGI 487
            |..||:.:.|    .:|....:|:|:|||:::.::..|.|.:|..::||.|||:..: ..||:|:
  Rat   449 LEEPFVMVSE----NVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQE-DGTWNGL 508

  Fly   488 VRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIY 552
            |.:|:...||:||..||:|..|...||||..:|...:.:|..: .....|:|:.|:||.|.:|..
  Rat   509 VGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRR-AEKTVDMFACLAPFDLSLWAC 572

  Fly   553 MGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAAS 617
            :....|.:.||::.|      :|.|| |..:...:.:. ::.|:.|...||.:.||.::.....:
  Rat   573 IAGTVLLVGLLVYLL------NWLNP-PRLQMGSMTST-TLYNSMWFVYGSFVQQGGEVPYTTLA 629

  Fly   618 TRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTM------ 676
            ||::.|.||.|||::::|||||||||||.:|..:||.|.:||:.|:.|.||.:...:..
  Rat   630 TRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMK 694

  Fly   677 ---GFFRDSNFSTYQKMWTAMESASPSVFTKTNDE-GVERVQKGKNLYAFLMESTTLEYNV--ER 735
               .|.||   |.|.:||..:..::.|.......: |:::|:.|.  |||:.::..|||..  :.
  Rat   695 GLNPFERD---SMYSQMWRMINRSNGSENNVLESQAGIQKVKYGN--YAFVWDAAVLEYVAINDP 754

  Fly   736 KCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCE---- 796
            .|....:|..:..:.||||:...||||...|..:|:|.:.|.:..||.|||.:   .|.|:
  Rat   755 DCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPK---NGQCDLYSS 816

  Fly   797 -KSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWN------VKSVAIEEKISLK--- 851
             .:.:.||   .|.::::.|||.:|..|::.:.::...|..|:      |.|...:::|.|:
  Rat   817 VDAKQKGG---ALDIKSLAGVFCILAAGIVLSCLIAVLETWWSRRKGSRVPSKEDDKEIDLEHLH 878

  Fly   852 --------------EAFKSEALFAARIWITTKPVHTSSE--SGSSNSSSSSSSRSKHSFKSQGLS 900
                          :.|.:.::....:.|.|.|...:.|  |...|:..::::......::...:
  Rat   879 RRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRT 943

  Fly   901 MKSLKSSGYQDVEASVH----------------SKLKKIGSMFSLKSQKTVTPPPEIGWKLDKST 949
            :.:..:||:.......|                |.:|   :|.|:..|.|.|....:|...|:.|
  Rat   944 LSAKAASGFTFGSVPEHRTGPFRHRAPNGGFFRSPIK---TMSSIPYQPTPTLGLNLGNDPDRGT 1005

  Fly   950 QI 951
            .|
  Rat  1006 SI 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	90/427 (21%)
		ANF_receptor	39..379	CDD:279440	80/393 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	123/384 (32%)
		Lig_chan	548..812	CDD:278489	85/280 (30%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		66/343 (19%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822	91/434 (21%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	123/384 (32%)
		Interaction with AP4M1. /evidence=ECO:0000269\|PubMed:14572453	921..991		9/72 (13%)
		PDZ-binding. /evidence=ECO:0000250	1005..1007		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349710
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740