DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clumsy and grik5-like.1

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001072565.1	Gene:	grik5-like.1 / 780020	XenbaseID:	XB-GENE-5860197	Length:	479	Species:	Xenopus tropicalis

Alignment Length:	491	Identity:	156/491 - (31%)
Similarity:	261/491 - (53%)	Gaps:	42/491 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 LNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNF 462
            ::.::|..||  |.|.:.|  |::.:..||....|          |..||:.|||::|:|:.|.|
Frog    28 IHKEKERSKR--QALKHLT--VTTIMEQPFSMKTE----------SGMEGFCIDLLSELAQSLGF 78

  Fly   463 KFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISIL 527
            .:..:...||:|||.:: ...|:|:|.:::...|||.:..||:|.:|.:.:.||.|||..|||||
Frog    79 NYTIKEVKDGRYGAKDQ-DGNWNGMVGEVLRKEADLAVAPLTITGARERELAFTKPFMQTGISIL 142

  Fly   528 FSKPPTPPTD-LFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIW 591
            ..|....... ||.||:|||.:.||.:..||:..||.||.:.|::|.:|      .|....:|.:
Frog   143 LRKDDVSENSYLFGFLTPFSKETWIGILVAYVVTSLCLFLVGRLSPCEW------TELSTEQNNF 201

  Fly   592 SIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFL-TNSRQANSINS 655
            :.:|:.|..:|:...||.:..||:.|.|::..:||.|:::::.:|.|:.|||| ::|.|..:|.:
Frog   202 NFLNSLWFGVGAFTLQGAEPHPKSVSARIIAVIWWIFSIVLVAAYIASFAAFLNSDSMQTTNIQT 266

  Fly   656 AEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLY 720
            .|||..|..:::|.:...||..||::|...||:.::..|:.....:..|:..|||.||::..  |
Frog   267 FEDLVNQRTLEFGTINSSSTFQFFKNSKNPTYRMIYEYMDKRKDELLVKSFAEGVRRVKESN--Y 329

  Fly   721 AFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKW 785
            |||.||...:..|.:.||||:....:..:.||||...:||..|.:|.|:|:..|.|.:..|::||
Frog   330 AFLGESVMQDIMVAKHCDLVRAPQIIAGRGYGIAASLDSPLIKPLSVAILEQTESGNIEYLRKKW 394

  Fly   786 WKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISL 850
            |     ...|......|.:..:  ...:||:||:||:||...::....|.:...::.|.::|.|.
Frog   395 W-----DNTCNMKRSAGWNPVQ--PHTLGGIFLILGIGLALGVIAALVELVLKARNNADQQKKSC 452

  Fly   851 KEAFKSEALFAARIWITTKPVHTSSES-GSSNSSSS 885
            ..||..|         ..:.:.|:.|: |:|:|:.|
Frog   453 CSAFSEE---------MGERLGTNKENQGASDSAKS 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377
		ANF_receptor	39..379	CDD:279440
		PBP2_iGluR_Kainate	414..787	CDD:270432	127/374 (34%)
		Lig_chan	548..812	CDD:278489	82/264 (31%)
grik5-like.1	NP_001072565.1	PBP2_iGluR_non_NMDA_like	41..396	CDD:270403	128/380 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910