DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clumsy and Ir7e

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster

Alignment Length:	482	Identity:	87/482 - (18%)
Similarity:	173/482 - (35%)	Gaps:	148/482 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   426 PFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQ 490
            |||||.|.|| |:|..|..|||   .|:..:|:.:||..           |:.||
  Fly   221 PFLTLDEDQE-EVLRVNGGYEG---RLLLALAEKMNFTI-----------AVRKV---------- 260

  Fly   491 LIDGNADLGICDLTMTSSRRQAVDFTPPFMTLG------------------------ISILFSKP 531
                  .:.:.|..:...||..||     :|||                        ..:|.|..
  Fly   261 ------HVNMRDEALEMLRRDEVD-----LTLGGIRQTVARGMVATSSHNYHQTREVFGVLASSY 314

  Fly   532 PTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIWSIMNT 596
            .....|:..:  |:.|.:|:.:.......:|:...:.||..:                  .:.:.
  Fly   315 ELSSFDILFY--PYRLQIWMGILGVVALSALIQLIVGRMLRE------------------RMGSR 359

  Fly   597 TWLSIGSLMGQGCDIL--PKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQAN----SINS 655
            .||:: .|:..|..:|  |::.:.||...|...:.|::...| ..|...|..:.|.|    :|.|
  Fly   360 FWLNL-ELVFVGMPLLECPRSHTARLYCVMLMMYTLIIRTIY-QGLLYHLIRTHQLNRWPQTIES 422

  Fly   656 -----------------AEDLAAQSKIKYGAMAGGSTMG--FFRDSNFSTYQKMWTAMESASPSV 701
                             .:::.:...:::..:...|.:.  :|.::|....|.    :.:::..:
  Fly   423 LVQKNFTVVLTPIVQEVLDEIPSVQHMRFRLLEANSELDPLYFLEANHQLRQH----VTASALDI 483

  Fly   702 FTKTN----DEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYR 762
            |...|    |:..:|.::|...:..::....:.         :|:..:|...|:.|
  Fly   484 FIHFNRLSADKVHQRGEQGSGAHFEIVPEDIIS---------MQLTMYLAKHSFLI--------- 530

  Fly   763 KQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSA 827
            .|::..::.:..:|.|:...|  |:........|:|.:      .||...:..:||::.:||
  Fly   531 DQLNEEIMWMRSVGLLSVWSR--WELSESYLRNEQSFQ------VLGTMELYAIFLMVLVGL--- 584

  Fly   828 MVLGCTEFLWNVKSVAIEEKISLKEAF 854
             ::|...|:..:.|:   ..|.|::.|
  Fly   585 -IVGLLVFILELVSM---RSIYLRKLF 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377
		ANF_receptor	39..379	CDD:279440
		PBP2_iGluR_Kainate	414..787	CDD:270432	72/413 (17%)
		Lig_chan	548..812	CDD:278489	43/292 (15%)
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	30/127 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462654
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740