DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clumsy and si:ch211-251b21.1

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001138274.1	Gene:	si:ch211-251b21.1 / 571720	ZFINID:	ZDB-GENE-060809-5	Length:	458	Species:	Danio rerio

Alignment Length:	449	Identity:	145/449 - (32%)
Similarity:	238/449 - (53%)	Gaps:	28/449 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   418 IVSSRLGA--------PFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKY 474
            :|||.|.|        |.......:|...::..|..||:.||:::.|:..|.||::..:..||:|
Zfish     8 LVSSALLAGLCTAGPQPLKVTTIKEEPYAMSKGSELEGFCIDMLSAISNKLGFKYDVHLVKDGRY 72

  Fly   475 GALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKP-PTPPTDL 538
            |..:. :..|:|::.:::.|.||:.:..||:|:.|...||.:.|||..|:|.:..|. .:..:..
Zfish    73 GKTDD-SGNWNGMIGEVVRGEADIAVAPLTLTAQREAVVDMSKPFMQTGLSFIMRKDLGSDDSQF 136

  Fly   539 FSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIWSIMNTTWLSIGS 603
            .|.|..||.::|:.:..|||..|:.:|.::|::|.:||      :||:..|.:::.::.|.::|:
Zfish   137 LSLLKLFSTEMWMGVLVAYLLTSICIFLVSRISPCEWE------QPEKDNNSFTLSHSFWYTVGA 195

  Fly   604 LMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYG 668
            |..||....|||.|.|::|.:||.|:|::|..|.|||:.:|.:..|..||.:.||||.|:.|:||
Zfish   196 LTLQGAGPHPKALSGRVITSIWWIFSLVLLACYFANLSLWLHSDNQQLSIKTFEDLANQNVIEYG 260

  Fly   669 AMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNV 733
            .:...|:..||::||..||.:::..::.|..  ::....||..|.|||.  |||:.||.:|:..|
Zfish   261 TIKDSSSFNFFKNSNNPTYHRIYEHIKEAQS--YSLNAAEGFRRAQKGN--YAFIGESVSLDLAV 321

  Fly   734 ERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKS 798
            .|.|:|.:....:..:.|.||.|..||..|.:|.|:|:|.|.|:|...:.|||     ..:|...
Zfish   322 ARYCNLTRAPEIIGMRGYSIAAPLGSPLIKNLSVAILRLSESGELDYFRSKWW-----ASSCVAK 381

  Fly   799 DEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSE 857
            |..|.......|:   ||||:|..||...:.|...|.....:.||..|:.|......:|
Zfish   382 DSKGAPLKPASLK---GVFLLLAFGLGLGIFLALMELAAKSRKVANSEQKSCCSVMSAE 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377
		ANF_receptor	39..379	CDD:279440
		PBP2_iGluR_Kainate	414..787	CDD:270432	126/377 (33%)
		Lig_chan	548..812	CDD:278489	90/263 (34%)
si:ch211-251b21.1	NP_001138274.1	PBP2_iGluR_non_NMDA_like	25..375	CDD:270403	121/365 (33%)
si:ch211-251b21.1	NP_001138274.1	Lig_chan	146..396	CDD:278489	90/267 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.770